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Showing 1-30 of 2408 results for "H6167" within Papers
Abdulghani Al-Shehri et al.
Pharmaceutical research, 32(3), 1072-1083 (2014-09-23)
Owing to restricted access of pharmacological agents into the brain due to blood brain barrier (BBB) there is a need: 1. to develop a more representative 3-D-co-culture model of tumor-BBB interaction to investigate drug and nanoparticle transport into the brain
Robert T Dauchy et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(1), 40-50 (2015-02-05)
Early studies on rodents showed that short-term exposure to high-intensity light (> 70 lx) above 600 nm (red-appearing) influences circadian neuroendocrine and metabolic physiology. Here we addressed the hypothesis that long-term, low-intensity red light exposure at night (rLEN) from a
T Pina et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(10), 1995-2001 (2015-04-01)
Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases. To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients
Soichiro Murata et al.
International journal of molecular sciences, 16(6), 12051-12063 (2015-05-30)
Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of
Zhiping Hu et al.
Physical chemistry chemical physics : PCCP, 17(35), 22711-22720 (2015-08-11)
The aggregation and fibril formation of amyloid β(Aβ) peptides onto a ganglioside-GM1-containing lipid membrane is a cause of neurodegenerative diseases. The mechanism of the initial binding and the conformational changes of Aβ on the membrane should be clarified. Fluorescence microscopy
Gabriel F Ballester-Lozano et al.
The British journal of nutrition, 114(5), 713-726 (2015-07-30)
Seven isoproteic and isolipidic semi-purified diets were formulated to assess specific nutrient deficiencies in sulphur amino acids (SAA), n-3 long-chain PUFA (n-3 LC-PUFA), phospholipids (PL), P, minerals (Min) and vitamins (Vit). The control diet (CTRL) contained these essential nutrients in
N P Mikaelyan et al.
Bulletin of experimental biology and medicine, 159(2), 197-200 (2015-06-23)
Considerable changes in serum lipids and lipoprotein profiles associated with hypertriglyceridemia, hypercholesterolemia, increased VLDL and LDL concentrations, and reduced HDL level occur at the early stages of streptozotocin-induced diabetes (day 7) in rats. The level of saturated palmitic fatty acid
Fred K Tabung et al.
Annals of epidemiology, 25(6), 398-405 (2015-04-23)
Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a
T G Cotter et al.
Diabetes research and clinical practice, 106(3), e56-e59 (2014-12-03)
We sought to determine the attainment of targets for glycaemic control and vascular risk reduction in an Irish cohort of T1DM adults. Of 797 patients (53% male, mean age 40.3 ± 14.8 years, HbA1c 8.5 ± 1.6% (69.6 ± 17.8
Preeya Leelahagul et al.
Asian Pacific journal of allergy and immunology, 33(1), 59-64 (2015-04-05)
To assess three plasma adipokines that might act as biomarkers useful in determining persons exposed to asbestos. Sixty subjects were included in the study, 30 male workers from factories manufacturing cement products using chrysotile asbestos, and 30 volunteer controls comprising
Aurélie Goncalves et al.
Journal of lipid research, 56(6), 1123-1133 (2015-04-03)
Scavenger receptors (SRs) like cluster determinant 36 (CD36) and SR class B type I (SR-BI) play a debated role in lipid transport across the intestinal brush border membrane. We used surface plasmon resonance to analyze real-time interactions between the extracellular
Clemens Drenowatz et al.
Journal of science and medicine in sport, 18(6), 632-636 (2014-10-15)
The objective of this study was to examine the association between resistance exercise and cardiovascular disease risk, independent of body composition, physical activity and aerobic capacity, in healthy women. A cross-sectional analysis including 7321 women with no history of heart
Shunsuke Kitajima et al.
Stem cells (Dayton, Ohio), 33(5), 1657-1669 (2015-02-20)
Retinoblastoma tumor suppressor protein (RB) is inactivated more frequently during tumor progression than during tumor initiation. However, its exact role in controlling the malignant features associated with tumor progression is poorly understood. We established in vivo and in vitro models
Alena Koukalová et al.
Biochimica et biophysica acta, 1848(2), 444-452 (2014-12-03)
Didehydroroflamycoin (DDHR), a recently isolated member of the polyene macrolide family, was shown to have antibacterial and antifungal activity. However, its mechanism of action has not been investigated. Antibiotics from this family are amphiphilic; thus, they have membrane activity, their
Elizabeth M Waters et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2384-2397 (2015-02-13)
Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, we examined whether the membrane estrogen receptor, G-protein-coupled
Karin A L Müller et al.
Thrombosis and haemostasis, 114(3), 498-518 (2015-08-01)
Platelets play a pivotal role in chronic inflammation leading to progression of atherosclerosis and acute coronary events. Recent discoveries on novel mechanisms and platelet-dependent inflammatory targets underpin the role of platelets to maintain a chronic inflammatory condition in cardiovascular disease.
Petteri Parkkila et al.
Biochimica et biophysica acta, 1848(1 Pt A), 167-173 (2014-12-03)
Oxidative stress is involved in a number of pathological conditions and the generated oxidatively modified lipids influence membrane properties and functions, including lipid-protein interactions and cellular signaling. Brewster angle microscopy demonstrated oxidatively truncated phosphatidylcholines to promote phase separation in monolayers
Anne Mundstock et al.
International journal of pharmaceutics, 473(1-2), 232-238 (2014-07-06)
The saturation solubilities of nicotine and scopolamine bases as well as acidic paracetamol were measured in two different model stratum corneum lipid matrices. Light microscopy visualized the presence of drug above its solubility either as droplets or crystalline particles. Neither
Wei Li et al.
International journal of molecular sciences, 16(2), 2446-2457 (2015-01-27)
The aim of this paper is to evaluate the protective effect of 5-hydroxymethyl-2-furfural (5-HMF) on acute alcohol-induced liver oxidative injury in mice. 5-HMF, a maillard reaction product, was isolated from the fruits of Schisandra chinensis for animal experiments. Experimental ICR
Rajiv Chowdhury et al.
European journal of epidemiology, 30(7), 577-587 (2015-05-02)
During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, is a major cause of death in the country. However, there is limited
Yuting Zhao et al.
Biosensors & bioelectronics, 72, 348-354 (2015-05-26)
A new technology was developed to quantitatively detect a broad range of disease biomarkers and proven to be portable, economical, and conveniently accessible. Measurements were performed based on releasing encapsulated glucose from antibody-tagged liposomes and subsequently detecting the released glucose
Lihua Jin et al.
Scientific reports, 5, 17288-17288 (2015-12-02)
Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work
Madeleine Goeritzer et al.
Journal of lipid research, 55(12), 2562-2575 (2014-10-16)
Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-58 deficiency in murine macrophages, we generated mice with
Maria-Lucia Briuglia et al.
Drug delivery and translational research, 5(3), 231-242 (2015-03-20)
Cholesterol plays a strategic role in liposome composition; however, the quantity used to achieve an appropriate formulation has not been yet clarified. Therefore, by screening arrangement of lipids and cholesterol ratio, the main aim of this study is to investigate
P J Ruane et al.
HIV medicine, 16(5), 288-296 (2015-01-15)
Following antiretroviral therapy failure, patients are often treated with a three-drug regimen that includes two nucleoside/tide reverse transcriptase inhibitors [N(t)RTIs]. An alternative two-drug nucleoside-sparing regimen may decrease the pill burden and drug toxicities associated with the use of N(t)RTIs. The
A S Uys et al.
Journal of human hypertension, 28(7), 438-443 (2014-01-10)
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of
Yuan Zhu et al.
Archives of pharmacal research, 38(4), 512-521 (2014-09-19)
This study innovatively prepared an effective capsaicin-loaded liposome, a nanoformulation with fewer irritants, for oral administration. The in vitro and in vivo properties of the liposomal encapsulation were investigated and the potential possibility of oral administration evaluated. The liposomal agent
Ihsan Ates et al.
Scandinavian cardiovascular journal : SCJ, 49(5), 249-256 (2015-06-09)
We aimed to evaluate the levels of oxidative stress (OS) parameters such as total antioxidant status or TAS, total oxidant status (TOS), OS index (OSI), paraoxonase 1 (PON1), arylesterase, and total thiol in hypertensive patients with and without asymptomatic organ
Damien Denimal et al.
Atherosclerosis, 241(2), 752-760 (2015-07-06)
Phospholipids and sphingolipids are major components of HDL. They play a critical role in HDL functionality and protective effects against atherosclerosis. As HDL are dysfunctional in type 1 diabetic patients, we ascertained whether they presented abnormalities in their phospholipid and
Joep van der Leeuw et al.
Hypertension (Dallas, Tex. : 1979), 65(1), 115-121 (2014-10-15)
Blood pressure-lowering treatment reduces cardiovascular risk in patients with diabetes mellitus, but the effect varies between individuals. We sought to identify which patients benefit most from such treatment in a large clinical trial in type 2 diabetes mellitus. In Action
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