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  • [Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].

[Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].

Sudebno-meditsinskaia ekspertiza (2013-02-15)
Ia I Korenman, V K Shormanov, N Ia Mokshina, O A Krivosheeva, D V Klimanov
PMID23405468
ABSTRACT

The results of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions with organic solvents of different chemical nature and their mixtures are presented. Synergism between the distribution coefficients was demonstrated during the extraction of the above compounds with 1,4-dioxane and chloroform mixtures. The use of a chloroform--1,4-dioxane system in the molar ratio of 0.8:0.2 as a solvent resulted in the maximum values of distribution coefficients of 6-mercaptopurine and azathioprine.

MATERIALS
Product Number
Brand
Product Description
852678
Sigma-Aldrich
6-Mercaptopurine monohydrate, 98%
631833
Supelco
1,4-Dioxane solution, suitable for NMR (reference standard), 5 mM in benzene-d6 (99.6 atom % D), NMR tube size 3 mm × 8 in.
684228
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1,4-Dioxane solution, suitable for NMR (reference standard), 40% in benzene-d6 (99.6 atom % D), NMR tube size 10 mm × 8 in.
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1,4-Dioxane solution, suitable for NMR (reference standard), 40% in benzene-d6 (99.6 atom % D), chromium(III) acetylacetonate 5 mg/mL, NMR tube size 3 mm × 8 in.
631868
Supelco
1,4-Dioxane solution, suitable for NMR (reference standard), 5 mM in chloroform-d (99.8 atom % D), NMR tube size 3 mm × 8 in.
704814
Sigma-Aldrich
1,4-Dioxane solution, suitable for NMR (reference standard), 10 mM in D2O ("100%", 99.96 atom % D), NMR tube size 5 mm × 7 in.
360481
Sigma-Aldrich
1,4-Dioxane, ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer
611905
Sigma-Aldrich
1,4-Dioxane solution, suitable for NMR (reference standard), 40% in benzene-d6 (99.6 atom % D), chromium(III) acetylacetonate 5 mg/mL, NMR tube size 5 mm × 8 in.
296309
Sigma-Aldrich
1,4-Dioxane, anhydrous, 99.8%, contains <=25 ppm BHT as stabilizer
76887
Supelco
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D201863
Sigma-Aldrich
1,4-Dioxane, ReagentPlus®, ≥99%, contains ≤25 ppm BHT as stabilizer
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Supelco
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34857
Sigma-Aldrich
1,4-Dioxane, suitable for HPLC, ≥99.5%
551368
Sigma-Aldrich
1,4-Dioxane solution, suitable for NMR (reference standard), 40% in benzene-d6 (99.6 atom % D)
33147
Sigma-Aldrich
1,4-Dioxane, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
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1,4-Dioxane solution, suitable for NMR (reference standard), 40% in benzene-d6 (99.6 atom % D), NMR tube size 5 mm × 8 in.
319988
Sigma-Aldrich
Chloroform, contains ethanol as stabilizer, ACS reagent, ≥99.8%
472476
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288306
Sigma-Aldrich
Chloroform, anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer
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Sigma-Aldrich
Chloroform, ACS spectrophotometric grade, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer
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Sigma-Aldrich
Chloroform, contains 100-200 ppm amylenes as stabilizer, ≥99.5%
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Sigma-Aldrich
Chloroform, anhydrous, contains amylenes as stabilizer, ≥99%
02487
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Sigma-Aldrich
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Sigma-Aldrich
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