A case of mannitol hypersensitivity.

A case of mannitol hypersensitivity.

Journal of pediatric hematology/oncology (2013-09-26)

Donita D Lightner, Kevin De Braganca, Stephen W Gilheeney, Yasmin Khakoo, Kim Kramer, Morad Balas

ABSTRACT

Mannitol is used for increased intracranial pressure and prevention of nephrotoxicity. We present a case report of a patient who experienced an anaphylactic response to mannitol and review the literature.

MATERIALS

Product Number

Brand

Product Description

M9647

Sigma-Aldrich

D-Mannitol, ACS reagent

M4125

Sigma-Aldrich

D-Mannitol, ≥98% (GC)

63559

Sigma-Aldrich

D-Mannitol, BioUltra, ≥99.0% (sum of enantiomers, HPLC)

17311

Sigma-Aldrich

D-Mannitol, tested according to Ph. Eur.

63560

Millipore

D-Mannitol, ACS reagent, suitable for microbiology, ≥99.0%

78513

Supelco

D-Mannitol, ≥99.9999% (metals basis), for boron determination

M0200000

Mannitol, European Pharmacopoeia (EP) Reference Standard

D-015

Supelco

Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

PHR1007

Supelco

Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material

M9546

Sigma-Aldrich

D-Mannitol, BioXtra, ≥98% (HPLC)

M1902

Sigma-Aldrich

D-Mannitol, suitable for plant cell culture

M8429

Sigma-Aldrich

D-Mannitol, meets EP, FCC, USP testing specifications

D3630

Sigma-Aldrich

Diphenhydramine hydrochloride, ≥98% (HPLC)

PHR1015

Supelco

Diphenhydramine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

D2600000

Diphenhydramine hydrochloride, European Pharmacopoeia (EP) Reference Standard