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  • A comparison of retinyl palmitate and red palm oil β-carotene as strategies to address Vitamin A deficiency.

A comparison of retinyl palmitate and red palm oil β-carotene as strategies to address Vitamin A deficiency.

Nutrients (2013-08-21)
Ellie Souganidis, Arnaud Laillou, Magali Leyvraz, Regina Moench-Pfanner
ABSTRACT

Vitamin A deficiency continues to be an international public health problem with several important health consequences including blindness and overall increased rates of morbidity and mortality. To address this widespread issue, a series of strategies have been put into place from dietary diversification to supplementation and fortification programs. Retinyl palmitate has been used successfully for decades as a supplement as well as a way to fortify numerous foods, including vegetable oil, rice, monosodium glutamate, cereal flours and sugar. Recently, there has been rising interest in using a natural source of carotenoids, β-carotene from red palm oil (RPO), for fortification. Although RPO interventions have also been shown to effectively prevent Vitamin A deficiency, there are numerous challenges in using beta-carotene from RPO as a fortification technique. β-Carotene can induce significant changes in appearance and taste of the fortified product. Moreover, costs of fortifying with beta-carotene are higher than with retinyl palmitate. Therefore, RPO should only be used as a source of Vitamin A if it is produced and used in its crude form and regularly consumed without frying. Furthermore, refined RPO should be fortified with retinyl palmitate, not β-carotene, to ensure that there is adequate Vitamin A content.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
β-Carotene, synthetic, ≥93% (UV), powder
Sigma-Aldrich
β-Carotene, synthetic, ≥95% (HPLC), crystalline
Sigma-Aldrich
Retinyl palmitate, Type IV, ~1,800,000 USP units/g, oil
Sigma-Aldrich
Retinyl palmitate, potency: ≥1,700,000 USP units per g
Supelco
β-Carotene, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Retinol palmitate, analytical standard
Supelco
Retinyl Palmitate (Vitamin A Palmitate), Pharmaceutical Secondary Standard; Certified Reference Material