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  • An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy.

An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy.

ACS nano (2015-01-21)
Guang Yang, Jie Wang, Yi Wang, Long Li, Xing Guo, Shaobing Zhou
ABSTRACT

Nanocarriers have attracted broad attention in cancer therapy because of their ability to carry drugs preferentially into cancer tissue, but their application is still limited due to the systemic toxicity and low delivery efficacy of intravenously delivered chemotherapeutics. In this study, we develop a localized drug delivery device with combination of an active-targeting micellar system and implantable polymeric nanofibers. This device is achieved first by the formation of hydrophobic doxorubicin (Dox)-encapsulated active-targeting micelles assembled from a folate-conjugated PCL-PEG copolymer. Then, fabrication of the core-shell polymeric nanofibers is achieved with coaxial electrospinning in which the core region consists of a mixture of poly(vinyl alcohol) and the micelles and the outer shell layer consists of cross-linked gelatin. In contrast to the systematic administration of therapeutics via repeatedly intravenous injections of micelles, this implantable device has these capacities of greatly reducing the drug dose, the frequency of administration and side effect of chemotherapeutic agents while maintaining highly therapeutic efficacy against artificial solid tumors. This micelle-based nanofiber device can be developed toward the next generation of nanomedicine for efficient and safe cancer therapy.

MATERIALS
Product Number
Brand
Product Description

Supelco
Ethylene glycol, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Ethylene glycol solution, suitable for NMR (reference standard), 80% in DMSO-d6 (99.9 atom % D), NMR tube size 5 mm × 8 in.
Sigma-Aldrich
Ethylene glycol, anhydrous, 99.8%
Sigma-Aldrich
Ethylene glycol, BioUltra, ≥99.5% (GC)
Supelco
Ethylene glycol, analytical standard
Sigma-Aldrich
Doxorubicin hydrochloride, 98.0-102.0% (HPLC)
USP
Ethylene glycol, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Ethylene glycol, ReagentPlus®, ≥99%
Sigma-Aldrich
Ethylene glycol, spectrophotometric grade, ≥99%
Sigma-Aldrich
Ethylene glycol, Vetec, reagent grade, 98%
Sigma-Aldrich
Ethylene glycol 5 M solution
Supelco
1,2-Dichloroethane, analytical standard
Sigma-Aldrich
1,2-Dichloroethane, anhydrous, 99.8%
Sigma-Aldrich
DAPI, for nucleic acid staining
Sigma-Aldrich
1,2-Dichloroethane, ACS reagent, ≥99.0%