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Merck
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PPARA

peroxisome proliferator-activated receptor alpha

别名:
NR1C1, PPAR, PPARalpha, hPPAR
物种:
UniProtKB ID:
基因ID:
  • Human(5465) Summary: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
  • Mouse(19013) peroxisome proliferator activated receptor alpha
  • Rat(25747) peroxisome proliferator activated receptor alpha
  • domestic guinea pig(100135604) peroxisome proliferator activated receptor alpha
  • chicken(374120) peroxisome proliferator-activated receptor alpha
  • naked mole-rat(101725514) peroxisome proliferator-activated receptor alpha
  • Domestic Rabbit(100009308) peroxisome proliferator-activated receptor alpha
  • Goat(100861393) peroxisome proliferator-activated receptor alpha
  • sheep(100190976) peroxisome proliferator-activated receptor alpha
  • dog(403654) peroxisome proliferator-activated receptor alpha
  • Horse(100049840) peroxisome proliferator-activated receptor alpha
  • domestic cat(101095837) peroxisome proliferator-activated receptor alpha
  • domestic cat(100049013) peroxisome proliferator-activated receptor alpha
  • cow(281992) peroxisome proliferator-activated receptor alpha

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Small Molecule - Activator

货号
说明
物种
非诺贝特, ≥99%, powder,
物种
human
4-氯苯氧异丁酸, 97%,
物种
mouse, human
WY-14643, ,
物种
rat, human, mouse
苯扎贝特, ≥98%, solid,
物种
mouse, human

Small Molecule - Agonist

货号
说明
物种
非诺贝特, ≥99%, powder,
物种
human
吉非罗齐, ,
物种
human
非诺贝特, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
GW7647, ≥98% (HPLC),
物种
human
Fenofibrate Related Compound B, United States Pharmacopeia (USP) Reference Standard,
物种
human

Small Molecule - Antagonist

货号
说明
物种
GW0742, ≥98% (HPLC),
物种
human
油酰单乙醇胺, ~98% (TLC),
物种
human, mouse, rat

Antibodies

货号
说明
物种反应性
应用
Anti-PPAR-α antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence

western blot
抗-PPARα抗体, ascites fluid, Chemicon®,
物种反应性
human, mouse
应用
ELISA
immunocytochemistry

western blot
Anti-PPARα Antibody, clone 4G22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, canine, feline, human, monkey, mouse, porcine, rat
应用
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-PPARA antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, rat
应用
western blot
Anti-phospho PPAR alpha (Ser73), from rabbit,
物种反应性
bovine, human, mouse, rat
应用
dot blot
immunocytochemistry

immunofluorescence

immunohistochemistry

western blot

Proteins

货号
说明
物种
PPAR, α human, recombinant, expressed in E. coli, ≥75% (SDS-PAGE),
物种
human
PPARα, ligand binding domain (170-468) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
物种
human
PPARα isotype, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
物种
human
PPARα isotype, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human PPARA,
物种
human