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文件

PHR1246

非诺贝特

Name: 非诺贝特
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

2- [4-（4-氯苯甲酰）苯氧基]-2-甲基丙酸异丙酯

经验公式（希尔记法）:

C₂₀H₂₁ClO₄

CAS号:

49562-28-9

分子量:

360.83

EC 号:

256-376-3

MDL编号:

MFCD00133314

PubChem化学物质编号:

329823250

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. F0048000
traceable to USP 1269447

API family

fenofibrate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

InChI key

YMTINGFKWWXKFG-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fenofibrate is a third-generation fibric acid derivative which is widely employed for the treatment of atherogenic dyslipidemia, hypertriglyceridemia, mixed dyslipidemia and hypercholesterolemia.

应用

Fenofibrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometry techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0257 in the slot below. This is an example certificate only and may not be the lot that you receive.

1269447

非诺贝特, United States Pharmacopeia (USP) Reference Standard

F0048005

非诺贝特杂质A, European Pharmacopoeia (EP) Reference Standard

1269607

F0048010

非诺贝特杂质B, European Pharmacopoeia (EP) Reference Standard

1269629

1269618

F0048035

非诺贝杂质G, European Pharmacopoeia (EP) Reference Standard

1133558

Choline Fenofibrate, United States Pharmacopeia (USP) Reference Standard

PHR2864

危险声明

H412

预防措施声明

P273 - P501

危险分类

Aquatic Chronic 3

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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Estimation of Atorvastatin Calcium and Fenofibrate in Tablets by Derivative Spectrophotometry and Liquid Chromatography

Nakarani NV, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 90(3), 700-705 (2007)

Electrochemical studies and square-wave voltammetric determination of fenofibrate in pharmaceutical formulations

Yardimci C and Ozaltin N

Analytical and Bioanalytical Chemistry, 378(2), 495-498 (2004)

Simultaneous Estimation of Rosuvastatin Calcium and Fenofibrate in Bulk and in Tablet Dosage Form by UV-Spectrophotometry and RP-HPLC

Karunakaran A, et al.

Stamford Journal of Pharmaceutical Sciences, 4(1), 58-63 (2011)

Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial.

Mark D Sullivan et al.

JAMA psychiatry, 70(10), 1041-1047 (2013-08-16)

Depression has been identified as a risk factor for dementia among patients with type 2 diabetes mellitus but the cognitive domains and patient groups most affected have not been identified. To determine whether comorbid depression in patients with type 2

Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems.

Wei He et al.

International journal of pharmaceutics, 445(1-2), 69-78 (2013-02-12)

A novel biocompatible shell-crosslinked nanocapsule system was developed based on nanoemulsion templates stabilized by a class of food proteins. The nanoemulsion templates were prepared using a combination of mechanical mixing and high-pressure homogenization, while the nanocapsule shell formed simultaneously through

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