C7081
WY-14643
Selective PPARα agonist, powder
别名:
4-氯-6-（2,3-二甲苯基）-2-嘧啶硫代乙酸, 匹立尼酸（降血脂药）
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关于此项目
经验公式（希尔记法）:
C14H14ClN3O2S
化学文摘社编号:
分子量:
323.80
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
WY-14643,
表单
powder
质量水平
SMILES字符串
CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2
InChI
1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChI key
SZRPDCCEHVWOJX-UHFFFAOYSA-N
基因信息
human ... PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013)
rat ... Ppara(25747)
一般描述
WY-14643 可防止脂多糖 (LPS) 诱导的滑膜成纤维细胞炎症。它能保护皮质神经元免受促炎介质诱导的细胞损伤。WY-14643 对小胶质细胞的促炎反应有抑制作用。它能改善疾病模型中的氧化-亚硝化应激，减少大脑中活性氧 (ROS)、一氧化氮 (NO) 和脂质过氧化终产物的生成。
应用
WY-14643 已被用于：
- 作为转染和荧光素酶检测的阳性对照
- ，刺激骨髓源性巨噬细胞 (BMDM) 进行自噬通量分析
- ，以分析细胞培养物中脂肪酸代谢-免疫联系 (FAMIN) 表达的调节
生化/生理作用
选择性 PPARα激动剂。
特点和优势
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
PPAR-alpha activation mediates innate host defense through induction of TFEB and lipid catabolism
Kim YS, et al.
Journal of Immunology, 198(8), 3283-3295 (2017)
Andrew D Patterson et al.
Hepatology (Baltimore, Md.), 56(1), 281-290 (2012-02-10)
Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis. Activation of the peroxisome proliferator-activated receptor alpha (PPARα), a member
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) alphagamma
Moldes-Anaya A, et al.
Marine drugs, 15(6), 148-148 (2017)
Ronald Lucarelli et al.
Frontiers in cellular and infection microbiology, 12, 881462-881462 (2022-07-22)
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory lipid mediators
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-alpha, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang R, et al.
Pharmacology, Biochemistry, and Behavior, 153, 97-104 (2017)
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