CN

58790

Sigma-Aldrich

(+)-Ds-苏式-异柠檬酸二氢钾

≥98.0% (NT)

别名:
Ds-(+)-苏式-异柠檬酸 单钾盐, (1R,2S)-1-羟基-1,2,3-丙烷三羧酸 单钾盐
Empirical Formula (Hill Notation):
C6H7KO7
CAS号:
分子量:
230.21
Beilstein/REAXYS Number:
3767339
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

测定

≥98.0% (NT)

旋光性

[α]20/D +20.5±1°, c = 2% in H2O

mp

~185 °C (dec.)

SMILES string

[K+].O[C@H]([C@H](CC(O)=O)C([O-])=O)C(O)=O

InChI

1S/C6H8O7.K/c7-3(8)1-2(5(10)11)4(9)6(12)13;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);/q;+1/p-1/t2-,4+;/m0./s1

InChI key

IVLPTBJBFVJENN-LEJBHHMKSA-M

应用

(+)-Ds-苏式-异柠檬酸钾可用于通过Kornberg方法对异柠檬酸脱氢酶2(Idh2)的活性进行评估。

包装

1 g in glass bottle
250 mg in glass bottle
无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

用作鉴定异柠檬酸脱氢酶时的底物

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Sarah E Anderson et al.
The Analyst, 145(11), 3899-3908 (2020-04-17)
The enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate (αKG) and has emerged as an important therapeutic target for glioblastoma multiforme (GBM). Current methods for assaying IDH1 remain poorly suited for high-throughput screening of IDH1 antagonists....
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Liu TF, et al.
The Journal of Biological Chemistry, 290(1), 396-408 (2015)
H Eguchi et al.
Biochimica et biophysica acta, 990(2), 133-137 (1989-02-24)
NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) was purified to electrophoretic homogeneity from an extremely thermophilic bacterium, Thermus thermophilus HB8, and shown to be a dimeric protein of molecular weight 115,000, with a pI of 5.5. The amino acid composition of the...
Kelsey H Fisher-Wellman et al.
Cell reports, 26(6), 1557-1572 (2019-02-07)
Acyl CoA metabolites derived from the catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translational modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has...
Ashley S Williams et al.
Cell metabolism, 31(1), 131-147 (2019-12-10)
This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl-CoA buffering and lysine deacetylation, due to genetic ablation of carnitine acetyltransferase and Sirtuin 3, respectively. DKO...
技术文章
Get to know the Tricarboxylic acid (TCA) cycle to better inform your research in biochemistry, metabolomics, or related fields concerned with this metabolic pathway and its enzymes, by-products, or intermediates.
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