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Merck
CN

860506P

Avanti

C6 神经酰胺 (d18:1/6:0)

Avanti Research - A Croda Brand

别名:

N-己酰-D-赤-鞘氨醇

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About This Item

经验公式(希尔记法):
C24H47NO3
分子量:
397.63
MDL编号:
UNSPSC代码:
12352211
NACRES:
NA.25

表单

powder

包装

pkg of 1 × 10 mg (860506P-10mg)
pkg of 1 × 5 mg (860506P-5mg)

制造商/商品名称

Avanti Research - A Croda Brand

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+

InChI key

NPRJSFWNFTXXQC-VHEBQXMUSA-N

一般描述

C6神经酰胺(d18:1/6:0)是一种具有细胞通透性的短链神经酰胺。它包含通过酰胺键与脂肪酰基链相连的氨基醇链。

应用

C6神经酰胺(d18:1/6:0)已被作为化疗药物用于测试其在乳腺癌细胞和卵巢癌细胞系中的抗肿瘤作用。它还被用于测试癌细胞中的化疗增敏作用。

生化/生理作用

C6神经酰胺(d18:1/6:0)可参与到增殖抑制和细胞凋亡诱导。当与酸性神经酰胺酶抑制剂DM102,即[(2R,3Z)-N-(1-羟基十八烷基-3-en-2-基)新戊酰酰胺]结合使用时,可有助于人乳腺癌细胞系的细胞死亡。C6神经酰胺可作为化疗的一种辅助手段。它可通过AKT(丝氨酸/苏氨酸特异性蛋白激酶)去磷酸化和α-微管蛋白乙酰化引发抗肿瘤作用。

包装

5 mL琥珀色玻璃螺旋盖小瓶(860506P-10mg)
5 mL琥珀色玻璃螺旋盖小瓶(860506P-5mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

通常也和此产品一起购买

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Short-chain C6 ceramide sensitizes AT406-induced anti-pancreatic cancer cell activity
Zhao X, et al.
Biochemical and Biophysical Research Communications, 479(2), 166-172 (2016)
Mechanisms involved in exogenous C2-and C6-ceramide-induced cancer cell toxicity
Fillet M, et al.
Biochemical Pharmacology, 65(10), 1633-1642 (2003)
C Ji et al.
Oncogene, 29(50), 6557-6568 (2010-08-31)
New chemotherapy-enhancing strategies are needed for better cancer therapy. Previous studies suggest that exogenous cell-permeable C6 ceramide may be a useful adjunct to the anti-tumor effects of chemotherapeutic agents (such as Taxol) against multiple cancers. Here we demonstrate that exogenous
C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study
Yang L, et al.
Experimental Cell Research, 332(1), 47-59 (2015)
C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and alpha-tubulin hyperacetylation both in vitro and in vivo
Zhu QY, et al.
Cell Death & Disease, 2(1), e117-e117 (2011)

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