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Merck
CN

237752

-吡哌酸

Proline homolog., 99%

别名:

-高脯氨酸, (S)-(& # 8722;)-2-哌啶羧酸

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关于此项目

经验公式(希尔记法):
C6H11NO2
化学文摘社编号:
分子量:
129.16
EC Number:
221-462-1
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
81093
MDL number:
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InChI key

HXEACLLIILLPRG-YFKPBYRVSA-N

InChI

1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1

SMILES string

OC(=O)[C@@H]1CCCCN1

assay

99%

form

powder with small lumps

optical activity

[α]25/D −26.4°, c = 1 in H2O

color

white

mp

272 °C (lit.)

application(s)

peptide synthesis

storage temp.

2-8°C

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General description

Occurs in seeds, malt, edible mushrooms, fruits, etc.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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S J Mihalik et al.
Pediatric research, 25(5), 548-552 (1989-05-01)
L-Pipecolic acid, a cyclic imino acid produced during the degradation of lysine, accumulates in body fluids of infants with the generalized peroxisomal disorders, including Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease. Peroxisome-enriched fractions from normal human liver oxidized L-[3H]pipecolic
D W Armstrong et al.
Journal of pharmaceutical and biomedical analysis, 11(10), 881-886 (1993-10-01)
Recently it was found that normal adults excrete pipecolic acid primarily as the D-enantiomer even though it is present in the blood stream mainly as the L-enantiomer (i.e. > 98% L). This study of pipecolic acid stereochemistry was extended to
M R Baumgartner et al.
Annals of neurology, 47(1), 109-113 (2000-01-13)
We describe an 18-year-old patient with psychomotor retardation and abnormally short metatarsi and metacarpals but no other signs of classic Refsum disease. Molecular analysis of the phytanoyl-coenzyme A hydroxylase gene revealed a homozygous deletion causing a frameshift. Surprisingly, L-pipecolic acid
T Fujita et al.
Clinica chimica acta; international journal of clinical chemistry, 287(1-2), 145-156 (1999-10-06)
Pipecolic acid, a metabolite of lysine, is found in human physiological fluids. It is known that plasma pipecolic acid levels are elevated in patients with Zellweger syndrome, a genetic disorder, and chronic liver diseases. However, it is uncertain if this
G A van den Berg et al.
Clinica chimica acta; international journal of clinical chemistry, 159(3), 229-237 (1986-09-30)
A capillary gas chromatographic method with mass spectrometric detection for the determination of pipecolic acid in urine and plasma (or serum) has been developed. Using a quantification based on stable isotope dilution mass fragmentography the concentration of pipecolic acid was

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