所有图片(1)

文件

852589

5-（羟甲基）尿嘧啶

Name: 5-（羟甲基）尿嘧啶
Brand: ALDRICH

97%

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所有图片(1)

经验公式（希尔记法）:

C₅H₆N₂O₃

CAS号:

4433-40-3

分子量:

142.11

EC 号:

224-636-5

MDL编号:

MFCD00006070

PubChem化学物质编号:

24888325

NACRES:

NA.22

检测方案

97%

形式

powder

mp

>300 °C (lit.)

SMILES string

[H]O[H].OCC1=CNC(=O)NC1=O

InChI

1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)

InChI key

JDBGXEHEIRGOBU-UHFFFAOYSA-N

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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示例

T1503

货号

25G

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Hideharu Hashimoto et al.

Nucleic acids research, 40(11), 4841-4849 (2012-03-01)

Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During semi-conservative DNA replication, hemi-methylated (M/C) and hemi-hydroxymethylated (H/C) CpG dinucleotides are transiently generated, where only the parental strand is

Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases.

Masaki Hori et al.

Nucleic acids research, 31(4), 1191-1196 (2003-02-13)

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC

Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.

Rafal Rozalski et al.

Free radical research, 38(11), 1201-1205 (2004-12-29)

In order to eliminate the possibility that diet may influence urinary oxidative DNA lesion levels, in our experiments we used a recently developed technique involving HPLC pre-purification followed by gas chromatography with isotope dilution mass spectrometric detection. This methodology was

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.

Hideharu Hashimoto et al.

Nucleic acids research, 40(17), 8276-8284 (2012-06-29)

The mammalian DNA glycosylase--methyl-CpG binding domain protein 4 (MBD4)--is involved in active DNA demethylation via the base excision repair pathway. MBD4 contains an N-terminal MBD and a C-terminal DNA glycosylase domain. MBD4 can excise the mismatched base paired with a

Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.

Neeraj Shakya et al.

Bioorganic & medicinal chemistry, 20(13), 4088-4097 (2012-06-06)

Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of mycobacterial infections due to the emerging global health threat of tuberculosis. We have identified a new class

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