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Merck
CN
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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84
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描述

ED<sub>80</sub> = 27 ± 7pg/mL ED<sub>50</sub>=125 ± 33 pg/mL ED<sub>20</sub>=652 ± 179 pg/mL
analytes available: Ghrelin
for protein analysis
10-2000 pg/mL (standard curve range)

质量水平

特点

accuracy 83–114%

种属反应性

human

灵敏度测量范围

10 pg/mL

技术

radioimmunoassay: suitable

UniProt登记号

检测方法

radioactive

一般描述

FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.

应用

Two-day disequilibrium assay at 4°C. Sample volume: ≤ 100 μL Plasma (collected on ice) recommended

分析说明

Linearity 100–142.5%

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Flam. Liq. 3 - STOT RE 2 Inhalation - STOT SE 1

靶器官

Eyes,Central nervous system, Respiratory Tract

储存分类代码

3 - Flammable liquids


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