A9519
N-乙酰胞壁酰基-L-丙氨酰基-D-异谷氨酰胺 水合物
≥98% (TLC), suitable for ligand binding assays
别名:
佐剂肽, 胞壁酰二肽
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关于此项目
经验公式（希尔记法）:
C19H32N4O11 · xH2O
化学文摘社编号:
分子量:
492.48 (anhydrous basis)
Beilstein:
4220745
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
N-乙酰胞壁酰基-L-丙氨酰基-D-异谷氨酰胺 水合物, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
技术
ligand binding assay: suitable
颜色
white
应用
cell analysis
储存温度
−20°C
SMILES字符串
C[C@H](NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(=O)N[C@H](CCC(O)=O)C(N)=O
InChI
1S/C19H32N4O11/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)/t7-,8+,10+,11+,13+,14+,15+,19?/m0/s1
InChI key
BSOQXXWZTUDTEL-QAQREVAFSA-N
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Amino Acid Sequence
MurNAc-Ala-Agn
应用
N-乙酰胞壁酰基-L-丙氨酰基-D-异谷氨酰胺水合物用于制备葡萄球菌细胞壁，以诱导人单核细胞释放TNF。
生化/生理作用
N-乙酰胞壁酰基-L-丙氨酰基-D-异谷氨酰胺（MDP，胞壁酰二肽）是细菌肽聚糖相关的神经营养和免疫调节因子，可用作增强免疫反应和研究神经发育的免疫调节因子。
增强弱抗原的抗原性，从而提高抗体滴度。
胞壁酰肽是构成细菌细胞壁肽聚糖的单体组分。它通常由哺乳动物巨噬细胞产生，是细菌细胞壁分解的免疫反应。MDP可促进白细胞介素-1和肿瘤坏死因子（TNF）的产生，从而增加慢波睡眠。
包装
无底玻璃瓶。内容物在嵌入的融合锥中。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Hui-Qing Liu et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(9), 2193-2201 (2013-07-23)
The activity of eicosanoid pathways is critical to the inflammatory and immune responses that are associated with the progression of atherosclerosis. Yet, the signals that regulate these pathways are poorly understood. Here, we address whether the innate immune signals of
Catherine Leimkuhler Grimes et al.
Journal of the American Chemical Society, 134(33), 13535-13537 (2012-08-04)
Mammalian Nod2 is an intracellular protein that is implicated in the innate immune response to the bacterial cell wall and is associated with the development of Crohn's disease, Blau syndrome, and gastrointestinal cancers. Nod2 is required for an immune response
Mohammad Salem et al.
Cellular and molecular life sciences : CMLS, 70(18), 3391-3404 (2013-01-01)
Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterations in genetic, microbiological, and immunological factors. This review is devoted to the role of the bacterial wall
Claudia Loganes et al.
World journal of gastroenterology, 22(44), 9734-9743 (2016-12-14)
To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide (MDP)-induced inflammation in Crohn's disease (CD) and ulcerative colitis (UC). Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples
Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans.
Timmerman CP
Infection and Immunity, 61(10), 4167-4172 (1993)
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