E7879
β-雌二醇 17-醋酸酯
≥99%
别名:
1,3,5(10)-雌三烯-3,17β-二醇 17-醋酸酯, 3,17β-二羟基-1,3,5(10)-雌三烯 17-醋酸酯
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关于此项目
经验公式（希尔记法）:
C20H26O3
化学文摘社编号:
分子量:
314.42
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2625732
sterility
non-sterile
Quality Level
assay
≥99%
form
powder
solubility
chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow
shipped in
ambient
storage temp.
room temp
SMILES string
CC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
InChI
1S/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1
InChI key
QAHOQNJVHDHYRN-SLHNCBLASA-N
Application
β-Estradiol 17-acetate has been used in body burden analyses, to study the effect of triclosan on an estuarine fish.
Biochem/physiol Actions
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, and hence is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 1 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Estrogen and the Vessel Wall, 38-38 (2003)
Bioactive Natural Products: Chemistry and Biology, 375-375 (2015)
Layer-by-Layer Films for Biomedical Applications, 517-517 (2014)
Anna Höckerstedt et al.
Journal of lipid research, 43(3), 392-397 (2002-03-15)
It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17beta-estradiol (E(2)) becomes esterified in LCAT-induced reactions and the esters are transported from HDL particles
Tomohiro Hikima et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 54(2), 155-160 (2002-08-23)
We have investigated the distribution of hydrolytic enzymes which metabolize beta-estradiol 17-acetate (EA) to beta-estradiol (E) in man and animal skins in vitro. The distribution of hydrolytic enzymes in human cadaver, hairless dog, rat and hairless mouse skin, was investigated
商品
Discover Bioactive Small Molecules for ADME/Tox
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E7879-5G | 04061833608517 |
| E7879-1G | 04061833608500 |
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