E9531
Ebastine
≥98% (HPLC), Histamine H1 receptor antagonist, solid
别名:
1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone
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关于此项目
经验公式（希尔记法）:
C32H39NO2
化学文摘社编号:
分子量:
469.66
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Ebastine, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
room temp
SMILES字符串
CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
InChI
1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI key
MJJALKDDGIKVBE-UHFFFAOYSA-N
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相关类别
一般描述
Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.
应用
Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.
生化/生理作用
Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.
Ebastine is a non-sedating histamine H1 receptor antagonist.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Daniel Aguilar et al.
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 56(2), 36-40 (2009-06-17)
Allergic rhinitis is an inflammatory disease of the nasal mucosa, with common symptoms, which is essentially characterized by nasal itching, nasal congestion, sneezing, hyaline rhinorrhea and repetitive sneezing. The disease is very common, 15% of the population worldwide suffers it.
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata.
Manabu Ohyama et al.
Journal of dermatological science, 58(2), 154-157 (2010-04-15)
N V Tsiskarishvili et al.
Georgian medical news, (167)(167), 52-56 (2009-03-12)
The clinical efficacy of antihistaminic preparation "Kestine" (Ebastine) in combined treatment of 50 patients suffering from photo-allergic dermatosis (15 - solar urticaria, 20 - solar erythema and 15 - solar eczema) are evaluated. Kestine in dosage of 10 mg a
Ji-Hong Shon et al.
Journal of clinical pharmacology, 50(2), 195-204 (2009-10-21)
The present study was performed to elucidate the effects of itraconazole and rifampin on the pharmacokinetics and pharmacodynamics of ebastine, a nonsedative H1 receptor antagonist. In a 3-way crossover sequential design with 2-week washouts, 10 healthy participants were pretreated with
M Magerl et al.
Clinical and experimental dermatology, 34(5), e137-e140 (2009-03-28)
In dermographic urticaria (DU), shearing forces on the skin result in weals and itching. Second-generation antihistamines are recommended as the first-line treatment, but to date only a few have ever been tested for this condition. The objective of this pilot
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