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E9531

Ebastine

Name: Ebastine
Brand: SIGMA

≥98% (HPLC), Histamine H1 receptor antagonist, solid

别名:

1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone

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关于此项目

经验公式（希尔记法）:

C₃₂H₃₉NO₂

化学文摘社编号:

90729-43-4

分子量:

469.66

UNSPSC Code:

12352200

PubChem Substance ID:

329799086

NACRES:

NA.77

MDL number:

MFCD00865661

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

产品名称

Ebastine, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

room temp

SMILES string

CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3

InChI key

MJJALKDDGIKVBE-UHFFFAOYSA-N

说明

General description

Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.

Application

Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.

Biochem/physiol Actions

Ebastine is a non-sedating histamine H₁receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.

Ebastine is a non-sedating histamine H₁ receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000536028

0000382372

0000194393

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商品

Histamine Receptors

We offers many products related to histamine receptors for your research needs.

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我们提供多种与组胺受体相关的产品，以满足您的各类研究需求。

Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.

Ji-Hong Shon et al.

Journal of clinical pharmacology, 50(2), 195-204 (2009-10-21)

The present study was performed to elucidate the effects of itraconazole and rifampin on the pharmacokinetics and pharmacodynamics of ebastine, a nonsedative H1 receptor antagonist. In a 3-way crossover sequential design with 2-week washouts, 10 healthy participants were pretreated with

Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.

Edward D Levin et al.

European journal of pharmacology, 650(1), 256-260 (2010-10-19)

Nicotine has been definitively shown to be critically involved in the neural bases of tobacco addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration. Other

Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart.

W Kang et al.

British journal of pharmacology, 163(8), 1733-1739 (2011-03-18)

It is well established that cytochrome P450 2J (CYP2J) enzymes are expressed preferentially in the heart, and that ebastine is a substrate for CYP2J, but it is not known whether ebastine is metabolized in myocardium. Therefore, we investigated its pharmacokinetics

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全球贸易项目编号

货号	GTIN
E9531-10MG	04061832071992
E9531-50MG	04061832072005