M6045
2-甲基-4-异噻唑啉-3-酮 盐酸盐
≥99%
别名:
MIT, 甲基异噻唑啉酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C4H5NOS · HCl
化学文摘社编号:
分子量:
151.61
Beilstein:
3993054
EC 号:
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.76
生物来源
synthetic
质量水平
方案
≥99%
表单
powder
浓度
≤ 100%
技术
cell culture | mammalian: suitable
颜色
white to beige
mp
165—170 °C ((329 - 338 °F) at ca.990.4 hPa)
溶解性
water: soluble 10.0 — 10.4 mg/mL, clear, colorless to faint yellow or tan
适用性
suitable for component for culture media
应用
microbiology
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
Cl[H].CN1SC=CC1=O
InChI
1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
InChI key
SJXPQSRCFCPWQQ-UHFFFAOYSA-N
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一般描述
2-甲基-4-异噻唑啉-3-酮盐酸盐（MIT HCl，盐酸甲基异噻唑啉酮）是合成异噻唑啉酮的衍生物。
应用
盐酸甲基异噻唑啉酮(MIT HCl)已用于：
- 研究MIT作为细胞毒性物质，对支气管上皮细胞(BEAS-2B)的影响，及在凋亡性细胞死亡中的作用
- 研究酪氨酸磷酸化对神经轴突和树突发育过程中粘着斑激酶(FAK)活性的影响
生化/生理作用
2-甲基-4-异噻唑啉-3-酮盐酸盐(MIT HCl)是皮肤致敏物，会引起接触性皮炎和过敏。它在化妆品行业中广泛用作防腐剂。盐酸甲基异噻唑啉酮是一种神经毒素，过久暴露可能会引起神经元细胞死亡和神经突生长抑制。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1
补充剂危害
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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In compression with the intravenous administration, oral delivery most commonly used due to the non-invasive nature and the fact that avoids patient pain and discomfort. By consideration this aim, ibuprofen as a model drug was loaded into two-dimensional tunnels and
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Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
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Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
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Methylisothiazolinone (MIT) has been used in wide spectrum of fields due to its ability to inhibit microbial proliferation with low toxicity. Meanwhile, in Korea, the concern about the hazardous effects of MIT was amplified by the occurrence of patients that
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