P5806
Pasteurella multocida toxin
lyophilized powder
别名:
PMT
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关于此项目
Form:
lyophilized powder
Quality level:
sterility
sterile-filtered
Quality Level
form
lyophilized powder
packaging
vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)
storage temp.
−20°C
Biochem/physiol Actions
Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro. PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway. Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage
Pullinger GD, et al.
Molecular Microbiology, 51(1), 255-269 (2004)
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation
Harmey D, et al.
Journal of Bone and Mineral Research, 19(4), 661-670 (2004)
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and-independent mechanisms involvement of Gq but not G11
Zywietz A, et al.
The Journal of biological chemistry, 276(6) (2001)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P5806-1VL | 04061832941332 |