P7902
磷霉素 钙盐
别名:
Fosfomycin 钙盐, Phosphonomycin
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关于此项目
线性分子式:
C3H5O4PCa
化学文摘社编号:
分子量:
176.12
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
247-408-7
MDL number:
InChI key
YMZJBJPWTXJQMR-UHFFFAOYSA-L
InChI
1S/C3H7O4P.Ca/c1-2-3(7-2)8(4,5)6;/h2-3H,1H3,(H2,4,5,6);/q;+2/p-2
SMILES string
[Ca++].CC1OC1P([O-])([O-])=O
solubility
1 M HCl: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
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Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used to study resistance proteins in Bacillus subtilis and Mycobacterium tuberculosis. It is a potential treatment for bronchiectasis.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
Phosphomycin calcium salt blocks the formation or N-acetylmuramic acid by inhibiting UDP-Nacetylglucosamine 3-enolpyruvate transferase (MurA).
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
David L MacLeod et al.
The Journal of antimicrobial chemotherapy, 64(4), 829-836 (2009-08-15)
To compare the in vitro and in vivo activities of a 4:1 (w/w) fosfomycin/tobramycin combination (FTI) with those of fosfomycin and tobramycin alone against cystic fibrosis (CF) and non-CF bronchiectasis pathogens. Clinical isolates of CF Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus
M Cao et al.
Journal of bacteriology, 183(7), 2380-2383 (2001-03-13)
We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma(W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn(2+)-dependent glutathione
K A De Smet et al.
Microbiology (Reading, England), 145 ( Pt 11), 3177-3184 (1999-12-10)
Mycobacterium tuberculosis has innate resistance to a range of broad-spectrum antimicrobial agents. This may in part reflect the relative impermeability of the mycobacterial cell wall, but additional specific mechanisms may also be important. In the case of fosfomycin, it has
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