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显示 1-30 #N/A 151 条结果 关于 "06-549" 范围 论文
Zeeshan Zahoor Banday et al.
Molecular plant pathology, 19(2), 464-475 (2017-01-18)
A partly infected plant develops systemic acquired resistance (SAR) and shows heightened resistance during subsequent infections. The infected parts generate certain mobile signals that travel to the distal tissues and help to activate SAR. SAR is associated with epigenetic modifications
Jeroen M Bugter et al.
Life science alliance, 7(9) (2024-07-06)
The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for WNT. Loss-of-function mutations in RNF43 and ZNRF3 mediate FZD stabilisation and a WNT-hypersensitive growth
A silencer promotes the assembly of silenced chromatin independently of recruitment.
Lynch, PJ; Rusche, LN
Molecular and cellular biology null
Lucia Di Marcotullio et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(29), 10833-10838 (2004-07-14)
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also been described as the most frequent genetic defect in this human neoplasia.
Rui Liu et al.
The Journal of biological chemistry, 286(29), 26127-26137 (2011-06-02)
The neural cell adhesion molecule (NCAM) was recently shown to be involved in the progression of various tumors with diverse effects. We previously demonstrated that NCAM potentiates the cellular invasion and metastasis of melanoma. Here we further report that the
Hiroyuki Oya et al.
The Journal of biological chemistry, 284(47), 32472-32482 (2009-09-25)
Changes in the environment of a cell precipitate extracellular signals and sequential cascades of protein modification and elicit nuclear transcriptional responses. However, the functional links between intracellular signaling-dependent gene regulation and epigenetic regulation by chromatin-modifying proteins within the nucleus are
V M Draviam et al.
The Journal of cell biology, 152(5), 945-958 (2001-03-10)
In this paper, we show that substrate specificity is primarily conferred on human mitotic cyclin-dependent kinases (CDKs) by their subcellular localization. The difference in localization of the B-type cyclin-CDKs underlies the ability of cyclin B1-CDK1 to cause chromosome condensation, reorganization
Tatsuyuki Matsudaira et al.
Nature communications, 8(1), 1246-1246 (2017-11-03)
Yes-associated protein (YAP) is a recently discovered growth-promoting transcription coactivator that has been shown to regulate the malignancy of various cancers. How YAP is regulated is not fully understood. Here, we show that one of the factors regulating YAP is phosphatidylserine
Katherine J Sellers et al.
Neuropharmacology, 143, 153-162 (2018-10-01)
Estrogens have been shown to rapidly regulate local signalling at synapses and within the nucleus. The result of these signalling events is to rapidly modulate synapse structure and function, as well as epigenetic mechanisms including histone modifications. Ultimately these mechanisms
Claudia Dell'Amico et al.
eLife, 12 (2023-06-05)
WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions. Recessive mutations in WDR62 cause structural brain abnormalities and account for the second most common cause of autosomal recessive primary microcephaly (MCPH), indicating WDR62 as a critical hub for human
Shiuhwei Chen et al.
Frontiers in endocrinology, 12, 613964-613964 (2021-03-27)
Appropriate insulin secretion is essential for maintaining euglycemia, and impairment or loss of insulin release represents a causal event leading to diabetes. There have been extensive efforts of studying insulin secretion and its regulation using a variety of biological preparations
Gen Shiihashi et al.
EBioMedicine, 24, 102-115 (2017-09-21)
Cytoplasmic aggregation of fused in sarcoma (FUS) is detected in brain regions affected by amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which compose the disease spectrum, FUS proteinopathy. To understand the pathomechanism of ALS-FTD-associated FUS, we examined the behavior
Frédéric Jaskolski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(10), 2506-2515 (2004-03-12)
Kainate receptors (KARs) are heteromeric ionotropic glutamate receptors (GluRs) that play various roles in the regulation of synaptic transmission. The KAR subunits GluR5 and GluR6 exist under different splice variant isoforms in the C-terminal domain (GluR5a, GluR5b, GluR5c, GluR6a, GluR6b).
Elisabeth Pasch et al.
Biology open, 4(12), 1792-1802 (2015-12-02)
LINC complexes are evolutionarily conserved nuclear envelope bridges, physically connecting the nucleus to the peripheral cytoskeleton. They are pivotal for dynamic cellular and developmental processes, like nuclear migration, anchoring and positioning, meiotic chromosome movements and maintenance of cell polarity and
Pu-Yun Shih et al.
Acta neuropathologica communications, 8(1), 185-185 (2020-11-11)
Abnormal synaptic formation and signaling is one of the key molecular features of autism spectrum disorders (ASD). Cortactin binding protein 2 (CTTNBP2), an ASD-linked gene, is known to regulate the subcellular distribution of synaptic proteins, such as cortactin, thereby controlling
An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ.
Clerc, I; Polakowski, N; Andre-Arpin, C; Cook, P; Barbeau, B; Mesnard, JM; Lemasson, I
The Journal of Biological Chemistry null
Siddharth Pattnaik et al.
Scientific reports, 13(1), 9227-9227 (2023-06-08)
Home use tests to monitor hormone trends during the menstrual cycle have been available over-the-counter for a long time. However, these tests often depend upon manual readouts and hence may lead to false analysis. Furthermore, a lot of these tests
Ling-Shih Chang et al.
eLife, 9 (2020-01-15)
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibitor in human cancer cells and in the
Ana Domínguez-Ferreras et al.
Plant physiology, 168(3), 1106-1121 (2015-05-07)
The membrane-bound Brassinosteroid insensitive1-associated receptor kinase1 (BAK1) is a common coreceptor in plants and regulates distinct cellular programs ranging from growth and development to defense against pathogens. BAK1 functions through binding to ligand-stimulated transmembrane receptors and activating their kinase domains
Joseph V Geisberg et al.
Molecular cell, 14(4), 479-489 (2004-05-20)
Mot1 associates with transcriptionally active promoters, and it directly affects transcriptional activity in a positive or negative manner, depending on the gene. As determined by sequential chromatin immunoprecipitation, Mot1 co-occupies promoters with TBP, but not with TFIIB, TFIIA, or Pol
Miriam Sturm et al.
Nature communications, 8(1), 2213-2213 (2017-12-22)
Ribosome biogenesis begins in the nucleolus with the formation of 90S pre-ribosomes, from which pre-40S and pre-60S particles arise that subsequently follow separate maturation pathways. Here, we show how structurally related assembly factors, the KH domain proteins Krr1 and Dim2
Pu-Yun Shih et al.
Journal of cell science, 127(Pt 16), 3521-3534 (2014-06-15)
Neurons are characterized by subcellular compartments, such as axons, dendrites and synapses, that have highly specialized morphologies and biochemical specificities. Cortactin-binding protein 2 (CTTNBP2), a neuron-specific F-actin regulator, has been shown to play a role in the regulation of dendritic
The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain.
Lecaudey, V; Anselme, I; Rosa, F; Schneider-Maunoury, S
Development null
Emerson V Stewart et al.
The Journal of biological chemistry, 287(1), 672-681 (2011-11-17)
Schizosaccharomyces pombe Sre1 is a membrane-bound transcription factor that controls adaptation to hypoxia. Like its mammalian homolog, sterol regulatory element-binding protein (SREBP), Sre1 activation requires release from the membrane. However, in fission yeast, this release occurs through a strikingly different
Natalie K Lee et al.
Nature communications, 7, 11082-11082 (2016-04-01)
To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon
Meili Xu et al.
Molecular medicine reports, 16(4), 3783-3790 (2017-07-22)
Adenomatous polyposis coli (APC) and Axin interactions serve an important role in colorectal cancer (CRC) pathogenesis. The aim of the present study was to assess the combined effects of Axin and APC co‑expression in CRC cells, and to determine the
Differential trafficking of GluR7 kainate receptor subunit splice variants.
Jaskolski, F; Normand, E; Mulle, C; Coussen, F
The Journal of Biological Chemistry null
David S Moura et al.
Cellular and molecular life sciences : CMLS, 75(14), 2591-2611 (2018-01-18)
Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis. Vaccinia-related kinase 1 (VRK1) and Aurora B (AURKB) are two nuclear kinases involved in different steps of cell division.
Cheol Woong Ha et al.
Nucleic acids research, 40(11), 4892-4903 (2012-03-01)
In eukaryotic cells, ribosomal DNA (rDNA) forms the basis of the nucleolus. In Saccharomyces cerevisiae, 100-200 copies of a 9.1-kb rDNA repeat exist as a tandem array on chromosome XII. The stability of this highly repetitive array is maintained through
Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER.
Irizar A, Yu Y, Reed SH, Louis EJ, Waters R
Nucleic Acids Research null
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