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06-549
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Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer.
Zhu ML, Horbinski CM, Garzotto M, Qian DZ, Beer TM, Kyprianou N
Cancer Research null
Jennetta W Hammond et al.
Traffic (Copenhagen, Denmark), 9(5), 725-741 (2008-02-13)
Kinesin motors drive the intracellular transport of multiple cargoes along microtubule tracks; yet, how kinesins discriminate among their many potential cargoes is unknown. We tested whether Kinesin-1 cargoes compete, co-operate or are transported independently of each other. We focused on
Mallory Genest et al.
Journal of cell science, 135(7) (2022-04-09)
Altered endocytosis and vesicular trafficking are major players during tumorigenesis. Flotillin overexpression, a feature observed in many invasive tumors and identified as a marker of poor prognosis, induces a deregulated endocytic and trafficking pathway called upregulated flotillin-induced trafficking (UFIT). Here
Ester Orav et al.
Molecular neurobiology, 56(11), 7473-7489 (2019-05-03)
Kainate type ionotropic glutamate receptors (KARs) are expressed in hippocampal interneurons and regulate interneuron excitability and GABAergic transmission. Neuropilin tolloid-like proteins (NETO1 and NETO2) act as KAR auxiliary subunits; however, their significance for various functions of KARs in GABAergic interneurons
Bryan A Copits et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(20), 7334-7340 (2011-05-20)
Auxiliary proteins modify the biophysical function and pharmacological properties of ionotropic glutamate receptors and likely are important components of receptor signaling complexes in vivo. The neuropilin and tolloid-like proteins (NETO) 1 and NETO2, two closely related CUB domain-containing integral membrane
Meleah A Hickman et al.
PLoS genetics, 5(11), e1000710-e1000710 (2009-11-07)
Deacetylases of the Sir2 family regulate lifespan and response to stress. We have examined the evolutionary history of Sir2 and Hst1, which arose by gene duplication in budding yeast and which participate in distinct mechanisms of gene repression. In Saccharomyces
Lee E Finlan et al.
PLoS genetics, 4(3), e1000039-e1000039 (2008-03-29)
The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In vertebrates, chromosomal regions with low gene-density are located close to the nuclear periphery. Correlations have also been made between the transcriptional
Meleah A Hickman et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19384-19389 (2010-10-27)
The origin recognition complex (ORC) defines origins of replication and also interacts with heterochromatin proteins in a variety of species, but how ORC functions in heterochromatin assembly remains unclear. The largest subunit of ORC, Orc1, is particularly interesting because it
Adam D Langenbacher et al.
Developmental biology, 353(1), 19-28 (2011-02-23)
The specification of an appropriate number of cardiomyocytes from the lateral plate mesoderm requires a careful balance of both positive and negative regulatory signals. To identify new regulators of cardiac specification, we performed a phenotype-driven ENU mutagenesis forward genetic screen
Identification and molecular characterization of the mammalian ?-kleisin RAD21L.
Cristina Gutierrez-Caballero,Yurema Herran,Manuel Sanchez-Martin,Jose Angel Suja et al.
Cell Cycle null
Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
Chinnakkannu, P; Samanna, V; Cheng, G; Ablonczy, Z; Baicu, CF; Bethard, JR; Menick et al.
The Journal of Biological Chemistry null
Beatrice Argenti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(36), 8338-8346 (2005-09-09)
During the early development of the cerebellum, a burst of granule cell progenitor (GCP) proliferation occurs in the outer external granule layer (EGL), which is sustained mainly by Purkinje cell-derived Sonic Hedgehog (Shh). Shh response is interrupted once GCPs move
Sampada S Kharade et al.
Endocrinology, 159(2), 1199-1212 (2018-01-09)
The insulin-secreting pancreatic neuroendocrine tumors, insulinomas, characterized by increased pancreatic islet β-cell proliferation, express the phosphorylated isoform of the β-cell differentiation factor HLXB9 that interacts with NONO/p54NRB, a survival factor. Interestingly, two different homozygous germline mutations in HLXB9, p.F248L and
Shivali Kapoor et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(39), 12139-12144 (2015-09-16)
Point centromeres are specified by a short consensus sequence that seeds kinetochore formation, whereas regional centromeres lack a conserved sequence and instead are epigenetically inherited. Regional centromeres are generally flanked by heterochromatin that ensures high levels of cohesin and promotes
Profilin II regulates the exocytosis of kainate glutamate receptors.
Magali Mondin,Mario Carta,Elisabeth Normand,Christophe Mulle,Francoise Coussen
The Journal of Biological Chemistry null
Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.
Dugast-Darzacq, C; Pirity, M; Blanck, JK; Scherl, A; Schreiber-Agus, N
Oncogene null
Meleah A Hickman et al.
PLoS genetics, 3(8), e126-e126 (2007-08-07)
How duplicate genes provide genetic robustness remains an unresolved question. We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can provide genetic robustness against null mutations through a
Françoise Coussen et al.
Neuron, 47(4), 555-566 (2005-08-17)
Kainate receptors (KAR) are composed of several distinct subunits and splice variants, but the functional relevance of this diversity remains largely unclear. Here we show that two splice variants of the GluR6 subunit, GluR6a and GluR6b, which differ in their
Collaborative competition mechanism for gene activation in vivo.
Joanna A Miller, Jonathan Widom
Molecular and cellular biology null
Ana Martín-Vega et al.
Science advances, 9(7), eadd7969-eadd7969 (2023-02-16)
RAS-ERK (extracellular signal-regulated kinase) pathway signals are modulated by scaffold proteins that assemble the components of different kinase tiers into a sequential phosphorylation cascade. In the prevailing model scaffold proteins function as isolated entities, where the flux of phosphorylation events
David S Moura et al.
Cellular and molecular life sciences : CMLS, 75(14), 2591-2611 (2018-01-18)
Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis. Vaccinia-related kinase 1 (VRK1) and Aurora B (AURKB) are two nuclear kinases involved in different steps of cell division.
Siddharth Pattnaik et al.
Scientific reports, 13(1), 9227-9227 (2023-06-08)
Home use tests to monitor hormone trends during the menstrual cycle have been available over-the-counter for a long time. However, these tests often depend upon manual readouts and hence may lead to false analysis. Furthermore, a lot of these tests
Risa Burr et al.
The Journal of biological chemistry, 292(39), 16333-16350 (2017-08-20)
Sterol regulatory element-binding proteins (SREBPs) in the fission yeast Schizosaccharomyces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxygen availability. SREBPs are cleaved in the Golgi through the combined action of the Dsc E3
Maria Vivo et al.
PloS one, 8(1), e53631-e53631 (2013-01-12)
The INK4a/ARF locus on the short arm of chromosome 9 is one of the most frequently altered loci in human cancer. It is generally accepted that ARF is involved in oncogenic checkpoint pathways by sensitizing incipient cancer cells to undergo
Angela M Halstead et al.
Mechanisms of development, 136, 155-165 (2014-12-17)
The winged-helix transcription factor Foxh1 is an essential regulator of Nodal signaling during the key developmental processes of gastrulation, anterior-posterior (A-P) patterning, and the derivation of left-right (L-R) asymmetry. Current models have Foxh1 bound to phospho-Smad2/3 (pSmad2/3) as a central
Vasily S Romanov et al.
Oncotarget, 5(8), 2176-2186 (2014-04-20)
The adenoviral oncoprotein E1A influences cellular regulation by interacting with a number of cellular proteins. In collaboration with complementary oncogenes, E1A fully transforms primary cells. As part of this action, E1A inhibits transcription of c-Jun:Fos target genes while promoting that
Lucia Di Marcotullio et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(29), 10833-10838 (2004-07-14)
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also been described as the most frequent genetic defect in this human neoplasia.
Tzu-Wei Chuang et al.
The Journal of biological chemistry, 291(16), 8565-8574 (2016-02-19)
Eukaryotic mRNA biogenesis involves a series of interconnected steps mediated by RNA-binding proteins. The exon junction complex core protein Y14 is required for nonsense-mediated mRNA decay (NMD) and promotes translation. Moreover, Y14 binds the cap structure of mRNAs and inhibits
Michael P O'Donnell et al.
Development (Cambridge, England), 140(13), 2724-2733 (2013-05-31)
To develop a functional nervous system, axons must initially navigate through a complex environment, directed by guidance ligands and receptors. These receptors must link to intracellular signaling cascades to direct axon pathfinding decisions. The Abelson tyrosine kinase (Abl) plays a
Bryan A Copits et al.
The Journal of biological chemistry, 288(13), 8952-8965 (2013-02-13)
Kainate receptors exhibit a highly compartmentalized distribution within the brain; however, the molecular and cellular mechanisms that coordinate their expression at neuronal sites of action are poorly characterized. Here we report that the GluK1 and GluK2 kainate receptor subunits interact
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