07-662

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关键词:'07-662'

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Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet.

Byounghoon Hwang et al.

The FEBS journal, 279(10), 1883-1893 (2012-03-21)

Although improving glucose metabolism by inhibition of pyruvate dehydrogenase kinase 4 (PDK4) may prove beneficial in the treatment of type 2 diabetes or diet-induced obesity, it may have detrimental effects by inhibiting fatty acid oxidation. Peroxisome proliferator-activated receptor α (PPARα)

A novel steroidal inhibitor of estrogen-related receptor alpha (ERRalpha).

Duellman SJ, Calaoagan JM, Sato BG, Fine R, Klebansky B, Chao WR, Hobbs P, Collins N et al.

Biochemical Pharmacology null

PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ.

Bo Yu et al.

Cell stem cell, 23(2), 193-209 (2018-07-19)

Aberrant lineage specification of skeletal stem cells (SSCs) contributes to reduced bone mass and increased marrow adipose tissue (MAT) in osteoporosis and skeletal aging. Although master regulators of osteoblastic and adipogenic lineages have been identified, little is known about factors

SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression.

Kimberly R Holloway et al.

Molecular endocrinology (Baltimore, Md.), 27(3), 480-490 (2013-01-24)

Breast cancer remains one of the leading causes of death in women diagnosed with cancer. In breast cancer, aberrant expression of the CYP19A1 gene, which encodes the aromatase enzyme, contributes to increased intratumoral levels of estradiol. Regardless of whether this

Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.

Tremblay, AM; Wilson, BJ; Yang, XJ; Giguere, V

Molecular Endocrinology null

The mouse estrogen receptor-related orphan receptor alpha 1: molecular cloning and estrogen responsiveness.

H Shigeta et al.

Journal of molecular endocrinology, 19(3), 299-309 (1998-02-14)

Estrogen receptor-related orphan receptor alpha 1 is a member of the steroid/thyroid nuclear receptor superfamily. We have previously cloned the human estrogen receptor-related orphan receptor alpha 1 (hERR alpha 1) cDNA and demonstrated that it enhances estrogen responsiveness of the

MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells.

Zhao, Y; Li, Y; Lou, G; Zhao, L; Xu, Z; Zhang, Y; He, F

Testing null

Phenotypic and phylogenetic segregation of Alternaria infectoria from small-spored Alternaria species isolated from wheat in Germany and Russia.

S M Kahl et al.

Journal of applied microbiology, 119(6), 1637-1650 (2015-09-19)

To identify the taxonomic differences between phytopathogenic small-spored Alternaria strains isolated from wheat kernels in Germany and Russia by a polyphasic approach. Ninety-five Alternaria (A.) strains were characterized by their colony colour, their three-dimensional sporulation patterns, mycotoxin production and phylogenetic

A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia.

Jin Zhou et al.

Thyroid : official journal of the American Thyroid Association, 29(8), 1158-1167 (2019-07-25)

Background: Glycogen storage disease type Ia (GSD Ia), also known as von Gierke disease, is the most common glycogen storage disorder. It is caused by the deficiency of glucose-6-phosphatase, the enzyme that catalyzes the final step of gluconeogenesis and glycogenolysis.

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