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1.4.3.4
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M S Dar et al.
General pharmacology, 16(6), 557-560 (1985-01-01)
The metabolism of methylamine has been investigated in the rat in order to elucidate the role of monoamine oxidase (MAO; EC 1.4.3.4) and intestinal bacteria in the metabolism of the compound. In a series of experiments in which short- and
C Halldin et al.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 40(7), 557-560 (1989-01-01)
Dimethylphenethylamine (DMPA), a substrate for the B-form of the monoamine oxidase enzyme (MAO, EC 1.4.3.4), was labelled with 11C in two different positions; in the methyl group (M-DMPA) and in the phenethyl group (P-DMPA). M-DMPA was prepared by N-alkylation of
R M Denney
Progress in brain research, 106, 57-66 (1995-01-01)
Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Evidence that MAO A deficient males in a large Dutch kindred suffer from mild mental retardation and occasional episodes of impulsive-aggressive behavior
U Thull et al.
Biochemical pharmacology, 47(12), 2307-2310 (1994-06-15)
A number of unsubstituted aromatic hydrocarbons, azaheterocycles, oxaheterocycles and cyclic ketones were screened for their inhibitory potency towards monoamine oxidases (MAO; EC 1.4.3.4.) A and B. Fair activities (IC50 10-100 microM) and selectivities were found for, e.g. naphthalene, anthracene, phenanthrene
J Grimsby et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(9), 3637-3641 (1991-05-01)
Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries
Naoyuki Kobayashi et al.
Life sciences, 70(13), 1519-1531 (2002-03-16)
Various mammalian tissues contain a tissue-bound amine oxidizing enzyme distinct from mitochondrial outer membrane enzyme, monoamine oxidase (MAO, EC 1.4.3.4), termed semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6). An increase in SSAO activity was found in patients suffering from vascular disorders
L W Hunter et al.
Biochemical pharmacology, 45(6), 1363-1366 (1993-03-24)
The activity of the enzyme tyrosine hydroxylase (TH; EC 1.14.16.2) is commonly studied indirectly by quantifying the formation of the product, 3,4-dihydroxyphenylalanine (DOPA), after inhibition of aromatic L-amino acid decarboxylase (AAAD; EC 4.1.1.28), the enzyme which metabolizes DOPA. This study
L B Pearce et al.
Biochemistry, 24(8), 1821-1826 (1985-04-09)
Recently, evidence has been published which suggests that [Husain, M., Edmondson, D. E., & Singer, T.P. (1982) Biochemistry 21, 595-600] monoamine oxidase [amine:oxygen oxidoreductase (MAO), EC 1.4.3.4] deaminates phenylethylamine and benzylamine via two distinct kinetic pathways which involve either binary
L M Kochersperger et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 5(11), 2874-2881 (1985-11-01)
Monoamine oxidase (EC 1.4.3.4; MAO) is the primary enzyme responsible for the intraneuronal degradation of biogenic amines in the central nervous system. An understanding of the physiological significance of the functional and regulatory differences between the two forms of the
O Yildiz et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 690-694 (2013-10-26)
Monoamine oxidase (MAO) inhibitors are generally used in the treatment of depressive disorders and some neurodegenerative illnesses, such as Parkinson's disease and Alzheimer's disease. The aim of this preliminary study was to investigate the MAO [MAO (E.C.1.4.3.4)] inhibiting effect of
J S Fowler et al.
Nature, 379(6567), 733-736 (1996-02-22)
The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that
T May
Neuroscience letters, 162(1-2), 55-58 (1993-11-12)
The in vitro binding of [3H]pargyline and [3H]harman ([3H]1-methyl-beta-carboline) to monoamine oxidase A (MAO-A; EC 1.4.3.4) on membranes of rat cerebral cortex was evaluated. Displacement of the [3H]pargyline binding on MAO-A (L(-)-deprenyl suppressed binding to MAO-B) by harman, 1-methyl-4-phenylpyridinium (MPP+)
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 120(1), 88P-90P (2002-12-21)
Recently it has been demonstrated a role of fat-cell SSAO on glucose transport and GLUT4 translocation to the cell surface. Many compounds have been identified as relatively selective SSAO inhibitors, but those currently available also inhibit monoamine oxidase (MAO, EC
W Lippman et al.
Canadian journal of physiology and pharmacology, 54(4), 494-509 (1976-08-01)
The effects of viloxazine, a clinically effective antidepressant, on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake and various related pharmacological activities were determined and compared to those of the tricyclic antidepressants desimipramine, imipramine, and amitriptyline. Viloxazine inhibitied [3H]NA uptake in the
R M Denney et al.
Journal of neurochemistry, 63(3), 843-856 (1994-09-01)
Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Recent evidence that MAO A-deficient males in a large Dutch kindred suffer from mild mental retardation and occasional episodes of impulsive aggressive
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