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L V Boĭchenko et al.
Prikladnaia biokhimiia i mikrobiologiia, 39(3), 335-340 (2003-05-21)
Conditions of agroclavine biosynthesis by the mutant Claviceps sp. strain s 106 were studied. The content of agroclavine was maximum (1.5-2 g/l) on days 15-16 of cultivation in the complex medium T25, containing sucrose, citric acid, and yeast extract. Agroclavine
Marlene C Nielsen et al.
Immunology, 159(1), 63-74 (2019-10-02)
Monocyte-derived macrophages (MDMs) generated from peripheral blood monocytes are widely used to model human macrophages for in vitro studies. However, the possible impact of different isolation methods on the resulting MDM phenotype is poorly described. We aimed to investigate the
Ming-zhe Sun et al.
Biotechnology letters, 37(9), 1877-1886 (2015-05-23)
To acquire a thermostable xylanase, that is suitable for xylooligosaccharide production from pretreated corncobs, the metagenomic method was used to obtain the gene from an uncultured environmental microorganism. A thermostable xylanase-encoding gene (xyn10CD18) was cloned directly from the metagenomic DNA
Thierry Burnouf et al.
Analytical biochemistry, 389(1), 69-73 (2009-03-24)
The capacity of hydrophobic octadecyl (C18) and SDR HyperD materials to remove the combination of 1% (v/v) solvent (tri-n-butyl phosphate, TnBP) with 1% (v/v) nonionic detergents (Triton X-100 and Triton X-45) used for viral inactivation of plasma-derived polyvalent intravenous immunoglobulin
Chao Xu et al.
Fish & shellfish immunology, 105, 195-202 (2020-07-12)
A 10-week feeding trial was performed to investigate the effects of Streptococcus faecalis on the growth, intestinal microflora composition and expression of immune-related genes of blunt snout bream (Megalobrama amblycephala). Fish (46.32 ± 0.09 g) were fed four experimental diets containing 0 cfu/g (SF0
Rupal P Soder et al.
Stem cell reviews and reports, 16(5), 979-991 (2020-08-03)
Because of their well-described immunosuppressive properties, allogeneic adult human mesenchymal stromal cells (MSC) derived from bone marrow have demonstrated safety and efficacy in steroid refractory acute graft versus host disease (SR aGVHD). Clinical trials have resulted in variable success and
Daniele Campa et al.
PloS one, 7(11), e45232-e45232 (2012-11-08)
Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but
Volker Heinz et al.
Biotechnology progress, 21(6), 1632-1638 (2005-12-03)
The depolymerization of starch by beta-amylase during exposure to hydrostatic pressure up to 700 MPa and within a temperature range from 20 to 70 degrees C has been investigated. Inactivation of the enzyme as well as alterations in conversion speed
Henry L Keen et al.
Physiological genomics, 18(1), 33-42 (2004-04-01)
Diminished activity of peroxisome proliferator-activated receptor-gamma (PPARgamma) may play a role in the pathogenesis of hypertension and vascular dysfunction. To better understand what genes are regulated by PPARgamma, an experimental data set was generated by microarray analysis, in duplicate, of
Daisuke Ito et al.
PloS one, 14(3), e0213252-e0213252 (2019-03-07)
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety trials
A D Blann et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 13(2), 165-168 (2002-03-27)
Abnormal levels of soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP) and von Willebrand factor (vWf) are commonly found in breast and other cancers. However, the relationship between these molecules is unclear as raised sICAM-1 and vWf may simply reflect
Freya Droege et al.
Journal of clinical medicine, 9(3) (2020-03-18)
Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated
P Tonnerre et al.
Transplantation proceedings, 42(10), 4318-4321 (2010-12-21)
It is likely that the polymorphic MICA (MHC class I related chain A) molecules on graft endothelial cells (ECs) may be a target for specific antibodies and T cells directed against solid organ grafts. Although there is evidence for a
Omkar Byadgi et al.
Veterinary immunology and immunopathology, 234, 110217-110217 (2021-03-02)
The ectoparasite protozoan Amyloodinium ocellatum (AO) is the causative agent of amyloodiniosis in European seabass (ESB, Dicentrarchus labrax). There is a lack of information about basic molecular immune response mechanisms of ESB during AO infestation. Therefore, to compare gene expression
Carine Vergne-Vaxelaire et al.
Applied microbiology and biotechnology, 102(13), 5569-5583 (2018-05-08)
Most of the "repressor, open reading frame, kinase" (ROK) proteins already characterized so far, and exhibiting a kinase activity, take restrictedly D-glucose as substrate. By exploring the sequenced bacterial diversity, 61 ATP-dependent kinases belonging to the ROK family have been
G T Griffing et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 178-181 (1985-03-01)
19-Nor-deoxycorticosterone (19-nor-DOC) is a human mineralocorticoid. The regulation of its secretion is poorly understood, as renin angiotensin II (ANG II) stimulation has minimal effects on 19-nor-DOC. This study sought to determine if ANG II inhibition would decrease 19-nor-DOC production. Six
Andrew M Bellizzi
Histopathology, 76(2), 251-264 (2019-06-25)
Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation. Transcription factor immunohistochemistry is
Darren P Casey et al.
Journal of applied physiology (Bethesda, Md. : 1985), 113(8), 1201-1212 (2012-09-11)
We tested the hypothesis that elevated sympathetic tone is responsible for lower peak vasodilation after single muscle contractions in older adults. Young (n = 13, 7 men and 6 women, age: 27 ± 1 yr) and older (n = 13
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Chad C Carroll et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(1), R24-R30 (2013-05-03)
This study evaluated the activity and content of cyclooxygenase (COX)-1 and -2 in response to acute resistance exercise (RE) in human skeletal muscle. Previous work suggests that COX-1, but not COX-2, is the primary COX isoform elevated with resistance exercise
Rosario Pivonello et al.
The lancet. Diabetes & endocrinology, 8(9), 748-761 (2020-07-31)
Cushing's disease is a rare endocrine disorder characterised by cortisol overproduction with severe complications. Therapies for cortisol reduction are often necessary. Here we report the outcomes from the pivotal phase III study of osilodrostat (a potent oral inhibitor of cytochrome
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