141-90-2

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Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.

Tomohiro Kozako et al.

BMC cancer, 18(1), 791-791 (2018-08-08)

Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis

Purification and characterization of extracellular laccase secreted by Pleurotus sajor-caju MTCC 141.

R Sahay et al.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 24(12), 2068-2073 (2009-03-25)

The effect of lignin containing natural substrates corn-cob, coir-dust, saw-dust, wheat straw and bagasse particles on the extracellular secretion of laccase in the liquid culture growth medium of Pleurotus sajor-caju MTCC 141 has been studied. The culture conditions for maximum

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study.

Caetano Galvão Petrini et al.

Acta cytologica, 64(5), 442-451 (2020-07-01)

Persistent infection with high-risk human papillomavirus (HPV) types is associated with high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local immune response to

PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours.

Shunichi Toki et al.

Histopathology, 73(4), 645-652 (2018-06-20)

Ewing sarcoma is a small round cell tumour that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies

Angiotensin II hypertension is attenuated in interleukin-6 knockout mice.

Dexter L Lee et al.

American journal of physiology. Heart and circulatory physiology, 290(3), H935-H940 (2005-11-15)

Plasma levels of IL-6 correlate with high blood pressure under many circumstances, and ANG II has been shown to stimulate IL-6 production from various cell types. This study tested the role of IL-6 in mediating the hypertension caused by high-dose

Matrix metalloproteinase 2 activity decreases in human periodontal ligament fibroblast cultures submitted to simulated orthodontic force.

Rodolfo Assis Lisboa et al.

In vitro cellular & developmental biology. Animal, 45(10), 614-621 (2009-09-18)

Orthodontic force compresses the periodontal ligament promoting the expression of pro-inflammatory mediators and matrix metalloproteinases responsible for tooth movement. The extent in time while periodontal cells are being treated and the increment in the amount of mechanical stress caused by

Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients.

Imen Arfa et al.

Journal of the renin-angiotensin-aldosterone system : JRAAS, 9(1), 32-36 (2008-04-12)

The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. A case-control study was conducted among 141 unrelated type 2

Structure of the amino-terminal portion of the murine alpha 1(IV) collagen chain and the corresponding region of the gene.

P D Killen et al.

The Journal of biological chemistry, 263(18), 8706-8709 (1988-06-25)

Collagen IV, the major structural component of basement membranes, is composed of two genetically distinct polypeptide chains, alpha 1(IV) and alpha 2(IV). We have isolated a 522-base-pair (bp) cDNA to the 5' portion of the murine alpha 1(IV) chain mRNA

Effects of anti-phospholipase A(2) antibody supplementation on dry matter intake feed efficiency, acute phase response, and blood differentials of steers fed forage- and grain-based diets.

V R G Mercadante et al.

Journal of animal science, 93(2), 776-785 (2015-05-29)

To determine whether supplementation of anti-phospholipase A antibody (aPLA) would alter voluntary DMI, feed efficiency (FE), acute-phase protein concentration, and blood differentials (BD) due to a change in diet from a forage-based to a grain-based diet, individual daily DMI was

Determination of alpha 1-antitrypsin levels and of the presence of S and Z alleles in a population of patients with chronic respiratory symptoms.

Heliane Guerra Serra et al.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 34(12), 1019-1025 (2009-01-31)

To determine the levels of alpha-1 antitrypsin (AAT) and the presence of S and Z alleles in patients with chronic respiratory symptoms. Patients with chronic cough and dyspnea were submitted to clinical evaluation, pulmonary function tests, high-resolution computed tomography, nephelometric

Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature.

Andrew C Kithas et al.

Nitric oxide : biology and chemistry, 104-105, 51-60 (2020-09-27)

Nitric oxide synthase (NOS) inhibition with N(G)-monomethyl-l-arginine (L-NMMA) is often used to assess the role of NO in human cardiovascular function. However, the window of effect for L-NMMA on human vascular function is unknown, which is critical for designing and

In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC.

Kazuhiko Yanamoto et al.

Nuclear medicine and biology, 37(7), 853-860 (2010-09-28)

The translocator protein (18 kDa) (TSPO) is widely expressed in peripheral tissues, including the heart, lung, and kidney. Our laboratory developed N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC) as a TSPO positron emission tomography (PET) ligand. Here, using small-animal PET with [(18)F]FEDAC, we performed TSPO

Aquaporin-4 autoantibodies in a paraneoplastic context.

Sean J Pittock et al.

Archives of neurology, 65(5), 629-632 (2008-05-14)

The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders. Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context. To

Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension.

Ahmed A Elmarakby et al.

Hypertension (Dallas, Tex. : 1979), 47(3), 557-562 (2006-01-18)

We hypothesized that the downregulation of Cyp2c by tumor necrosis factor (TNF) alpha contributes to hypertension and renal injury in salt-sensitive angiotensin hypertension. Male Sprague-Dawley rats were fed a high-salt diet (8% NaCl), and osmotic minipumps were implanted to deliver

Factors Associated With Infarct-Related Artery Patency Before Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction (from the FAST-MI 2010 Registry).

Clotilde Bailleul et al.

The American journal of cardiology, 117(1), 17-21 (2015-11-07)

Early infarct-related artery (IRA) patency is associated with better clinical outcomes in patients with ST-elevation myocardial infarction (STEMI). Using the French Registry of ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) 2010 registry, we investigated factors related to IRA patency (thrombolysis in

Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA).

Carmen A Peralta et al.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 60(6), 904-911 (2012-07-04)

Whether elevations in levels of urinary biomarkers of tubular injury (urine neutrophil gelatinase-associated lipocalin [NGAL] and kidney injury molecule 1 [KIM-1]) are associated with future risk of kidney disease has not been investigated. 1:1 nested case-control study. 686 participants in

Milk Polar Lipids Affect In Vitro Digestive Lipolysis and Postprandial Lipid Metabolism in Mice.

Manon Lecomte et al.

The Journal of nutrition, 145(8), 1770-1777 (2015-07-03)

Polar lipid (PL) emulsifiers such as milk PLs (MPLs) may affect digestion and subsequent lipid metabolism, but focused studies on postprandial lipemia are lacking. We evaluated the impact of MPLs on postprandial lipemia in mice and on lipid digestion in

[Relationship between hormone therapy in women with ovarian malignancy and prognosis].

Li Li et al.

Zhonghua fu chan ke za zhi, 43(11), 843-848 (2008-12-18)

To explore the relationship between hormone therapy (HT) in women with ovarian malignancy and prognosis. HT was used in 31 patients with ovarian cancer after surgery, and 44 cases with ovarian cancer served as control. The expression of estrogen receptor

Distinct haplogenotypes of the dopamine D2 receptor gene are associated with non-smoking behaviour and daily cigarette consumption.

C Wernicke et al.

Pharmacopsychiatry, 42(2), 41-50 (2009-03-25)

Dopamine systems in the CNS are decisively implicated in the motivational and rewarding properties of nicotine. The dopamine D2 receptor (DRD2) plays a pivotal role by promoting these properties, making this gene a good candidate for association studies. Several single

Binding patterns of bovine seminal plasma proteins A1/A2, 30 kDa and osteopontin on ejaculated sperm before and after incubation with isthmic and ampullary oviductal fluid.

Carlos Eduardo A Souza et al.

Animal reproduction science, 105(1-2), 72-89 (2008-01-22)

Previous studies from our laboratory have reported empirical associations between bovine seminal plasma protein(s) (BSP) A1/A2 and 30 kDa and osteopontin (OPN) in accessory sex gland fluid and bull fertility. These BSP and OPN are believed to bind to sperm

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