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Michele Iafisco et al.
Journal of inorganic biochemistry, 117, 237-247 (2012-07-25)
The present review focuses on the "drug targeting and delivery" approach of the selective transportation of cisplatin to bone tumors and bone metastases. This aim is realized by binding cisplatin to (bis)phosphonate ligands or their derivatives. Geminal bisphosphonates are in
Tao Xiong et al.
Journal of biomedical nanotechnology, 9(2), 274-280 (2013-05-01)
Noninvasive molecular fluorescence imaging in vivo which combines Optical imaging with genetic marker technology can real time monitor the development of tumor, through the use of human adenoid cystic carcinoma cell (ACC-M) and lung carcinoma cells SPC-A1 were thansfected by
Pei-Miao Li et al.
Ying yong sheng tai xue bao = The journal of applied ecology, 23(12), 3514-3525 (2013-03-14)
Anthropogenic platinum group elements (PGEs) are widely applied in vehicle exhaust catalytic converters (VECs), industrial catalysts, and pharmaceutics, making the PGEs, especially Pt, Pd, and Rh, become the newly environmental pollutants in some fields. Given the positive correlations between the
Thorsten Langer et al.
Trends in pharmacological sciences, 34(8), 458-469 (2013-06-19)
Childhood cancer survival rates are now nearly 80% in more developed European countries because of improved therapies and better supportive care. Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer.
Catalysis: The accelerator.
Mark Peplow
Nature, 495(7440), S10-S11 (2013-03-15)
Hiroaki Akamatsu et al.
Japanese journal of clinical oncology, 43(6), 664-668 (2013-04-16)
Interstitial lung disease associated with gefitinib is a critical adverse reaction. When geftinib was administered to EGFR-unknown patients, the interstitial lung disease incidence rate was approximately 3-4% in Japan, and usually occurs during the first 4 weeks of treatment. However
Fausto Petrelli et al.
Lung cancer (Amsterdam, Netherlands), 81(3), 337-342 (2013-07-31)
The sole agents pemetrexed (PEM), docetaxel and anti-EGFR agents are approved second-line therapies for non-small cell lung cancer (NSCLC) after failure with cisplatin-based doublets. The potential usefulness of platinum-based doublets as rechallenge for second-line chemotherapy has not yet been established.
Ana S Fajardo et al.
Environmental technology, 34(1-4), 301-311 (2013-03-28)
Non-catalytic and catalytic ozonation over Pt/Al2O3 were considered in the treatment of a synthetic effluent composed of six phenolic acids usually present in olive mill wastewaters. In both processes the medium pH affected the rate of ozone decomposition and the
Hai-Bo Wei et al.
Chinese medical journal, 125(16), 2902-2907 (2012-08-31)
Platinum-based regimens are used as standard first-line chemotherapy in non-small cell lung cancer (NSCLC) patients. To study if pharmacogenetic approach may allow a tailored selection of platinum chemotherapy for advanced NSCLC, we performed a meta-analysis to compare chemosensitivity to platinum
Shanshan Cui et al.
BMC structural biology, 13, 4-4 (2013-03-23)
To explore novel platinum-based anticancer agents that are distinct from the structure and interaction mode of the traditional cisplatin by forming the bifunctional intrastrand 1,2 GpG adduct, the monofunctional platinum+DNA adducts with extensive non-covalent interactions had been studied. It was
J-H Franke et al.
The Journal of chemical physics, 138(8), 084705-084705 (2013-03-08)
The adsorption of the chiral molecule lactic acid on chiral Pt surfaces is studied by density functional theory calculations. First, we study the adsorption of L-lactic acid on the flat Pt(111) surface. Using the optimed PBE - van der Waals
Nicoletta Colombo
Future oncology (London, England), 9(12 Suppl), 19-23 (2013-11-15)
Ovarian cancer is the leading cause of gynecological cancer deaths worldwide. Despite primary treatment with platinum-containing regimens, the majority of women will experience recurrent disease and subsequent death. Recurrent ovarian cancer remains a challenge for successful management, and the choice
Emmanouil Kasotakis et al.
Methods in molecular biology (Clifton, N.J.), 996, 195-202 (2013-03-19)
Self-assembling peptides are water soluble and form biocompatible nanostructures under mild conditions through non-covalent interactions. They form supramolecular structures such as ribbons, nanotubes, and fibrils. Of particular interest is the possibility of using these peptide fibrils as templates for the
Mohammad Shamsuddin Ahmed et al.
Journal of nanoscience and nanotechnology, 13(1), 306-314 (2013-05-08)
Multi-walled carbon nanotube grafted Pt nanoparticles via nitrogen atom (MWCNT-N-Pt) has chemically synthesized and characterized as an efficient oxygen reduction reaction (ORR) catalysts. Structural and morphological properties of the electrocatalyst have characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy
Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Himashinie V K Diyabalanage et al.
Cancer letters, 329(1), 1-8 (2012-10-04)
One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has
Antonio González
Future oncology (London, England), 9(12 Suppl), 29-35 (2013-11-15)
Ovarian carcinoma is still one of the most common causes of death from cancer in the western world. Despite high sensitivity to chemotherapy, the majority of patients will relapse within 3 years. In this article the focus is centered on
Elisaveta Mladenova et al.
Journal of separation science, 35(10-11), 1249-1265 (2012-06-27)
A simple classification of various sorbents and solid-phase extraction procedures used for preconcentration of trace levels of Au, Pd, and Pt from different sample types is proposed in this review article. The large variety of available sorbents/procedures has been organized
Liang Li et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(11), 2451-2457 (2013-06-12)
This study investigated the mechanism and kinetic modeling of electrolytic degradation of ammonia with Pt/Ti anode. The results show that ammonia oxidation from direct oxidation or indirect oxidation with hydroxyl radicals was slow but can be observed under pH 9
A Gadducci et al.
European journal of gynaecological oncology, 34(3), 213-217 (2013-08-24)
To assess the pattern of failure and survival of advanced ovarian cancer patients with microscopic residual disease at second-look following cytoreductive surgery and platinum-based chemotherapy. Nine-five women were retrospectively analyzed. Residual disease after initial surgery was > one cm in
Yao-Hsuan Tseng et al.
Biochimica et biophysica acta, 1830(6), 3787-3795 (2013-04-02)
Traditional antibacterial photocatalysts are primarily induced by ultraviolet light to elicit antibacterial reactive oxygen species. New generation visible-light responsive photocatalysts were discovered, offering greater opportunity to use photocatalysts as disinfectants in our living environment. Recently, we found that visible-light responsive
Sung Jong Yoo et al.
Journal of nanoscience and nanotechnology, 13(5), 3591-3596 (2013-07-19)
Size-controlled PtRu nanoparticles embedded in WO3 were prepared by simultaneous multigun sputtering on pure targets of Pt, Ru, and WO3. The mean diameter of the PtRu nanoparticles, as confirmed by high-resolution transmission electron microscopy, can be varied from -2.3 to
Downregulation of glutathione transferase π sensitizes lymphoma/leukaemia cells to platinum-based chemotherapy.
Jianli Chen et al.
British journal of haematology, 162(1), 135-137 (2013-04-12)
Sang-Hyun Hong et al.
Optics express, 21(3), 3138-3144 (2013-03-14)
We demonstrate localized surface plasmon (LSP)-enhanced near-ultraviolet light-emitting diodes (NUV-LEDs) using silver (Ag) and platinum (Pt) nanoparticles (NPs). The optical output power of NUV-LEDs with metal NPs is higher by 20.1% for NUV-LEDs with Ag NPs and 57.9% for NUV-LEDs
Xiao-yong Shen et al.
PloS one, 8(8), e69553-e69553 (2013-08-14)
X-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC) patients
Josep Ramon Germà-Lluch et al.
Archivos espanoles de urologia, 66(5), 524-535 (2013-06-26)
Cisplatin has been the cornerstone of germ cell testicular tumors therapy since its introduction more tan 30 years ago, and a basic part of the schemes given to multiple ovarian, lung, head and neck, and bladder tumors among others. Some
C Mohn et al.
Die Pharmazie, 68(7), 622-627 (2013-08-09)
Albeit platinum complexes are widely used in cancer chemotherapy, their cellular processing has not been completely elucidated so far. In this study the effects of modulating multidrug resistance-associated protein (MRP)-mediated efflux and glutathione (GSH) depletion on the cytotoxicity of oxaliplatin
Y Yamagishi et al.
Die Pharmazie, 68(3), 178-182 (2013-04-06)
Nano-sized materials are widely used in consumer products, medical devices and engineered pharmaceuticals. Advances in nanotechnology have resulted in materials smaller than the nanoscale, but the biologic safety of the sub-nanosized materials has not been fully assessed. In this study
N H H Abu Bakar et al.
Journal of nanoscience and nanotechnology, 13(7), 5034-5043 (2013-08-02)
A detailed study on the surface properties of oleic acid-stabilized PtNi nanoparticles supported on silica is reported. The oleic acid-stabilized PtNi nanoparticles were synthesized using NaBH4 as the reducing agent at various temperatures and oleic acid concentrations, prior to incorporation
Yanlong Yang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(4), 2905-2921 (2013-12-18)
The relationship between the ERCC1/2 single nucleotide polymorphisms (SNPs) and the clinical outcomes of the platinum-based chemotherapy in the non-small cell lung cancer (NSCLC) is still inconsistent and inconclusive despite extensive investigations have been conducted to address this question. In
A G Quiroga
Journal of inorganic biochemistry, 114, 106-112 (2012-07-24)
This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by
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