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Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

摘要

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

材料

Product Number

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产品描述

Sigma-Aldrich

铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis

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铂, wire, diam. 1.0 mm, 99.9% trace metals basis

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铂, foil, thickness 0.025 mm, 99.9% trace metals basis

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铂, wire, diam. 0.5 mm, 99.9% trace metals basis

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铂, wire, diam. 0.5 mm, 99.99% trace metals basis

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铂, gauze, 52 mesh, 99.9% trace metals basis

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铂, wire, diam. 0.25 mm, 99.9% trace metals basis

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铂, gauze, 100 mesh, 99.9% trace metals basis

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铂黑, ≥99.9% trace metals basis

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铂, foil, thickness 0.05 mm, 99.99% trace metals basis

铂, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

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铂, nanopowder, <50 nm particle size (TEM)

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铂, wire, diam. 2.0 mm, 99.9% trace metals basis

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铂, wire, diam. 0.10 mm, 99.99% trace metals basis

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铂黑, low bulk density, ≥99.9% trace metals basis

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铂, wire, diam. 0.127 mm, 99.99% trace metals basis

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铂, wire, diam. 0.25 mm, 99.99% trace metals basis

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铂, foil, thickness 0.25 mm, 99.99% trace metals basis

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铂, sponge, ≥99.9% trace metals basis

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铂, wire, diam. 0.25 mm, thermocouple grade

Sigma-Aldrich

铂, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, shot, ≤3 mm, ≥99.9% trace metals basis

铂, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.99+%

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铂, powder (coarse), 99.99% trace metals basis

铂, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

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铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

铂, foil, 50x50mm, thickness 0.125mm, as rolled, 99.95%

铂, foil, 25x25mm, thickness 0.1mm, as rolled, 99.95%