CN

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

摘要

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

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铂, gauze, 100 mesh, 99.9% trace metals basis

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铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis

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铂, wire, diam. 0.5 mm, 99.99% trace metals basis

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铂, wire, diam. 0.25 mm, 99.9% trace metals basis

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铂, wire, diam. 2.0 mm, 99.9% trace metals basis

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铂, foil, thickness 0.025 mm, 99.9% trace metals basis

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铂, wire, diam. 1.0 mm, 99.9% trace metals basis

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铂, gauze, 52 mesh, 99.9% trace metals basis

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铂, powder, 99.995% trace metals basis

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铂黑, fuel cell grade, ≥99.9% trace metals basis

铂, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

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铂, nanopowder, <50 nm particle size (TEM)

Sigma-Aldrich

铂, wire, diam. 0.5 mm, 99.9% trace metals basis

铂, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

Sigma-Aldrich

铂, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.25 mm, 99.99% trace metals basis

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铂, wire, diam. 0.10 mm, 99.99% trace metals basis

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铂, wire, diam. 0.076 mm, ≥99.99% trace metals basis

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铂, wire, diam. 0.25 mm, 99.99% trace metals basis

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铂, foil, thickness 0.05 mm, 99.99% trace metals basis

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铂, powder (coarse), 99.99% trace metals basis

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铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

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铂, wire, diam. 0.127 mm, 99.99% trace metals basis

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铂, wire, diam. 0.25 mm, thermocouple grade

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铂黑, low bulk density, ≥99.9% trace metals basis

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铂, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

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铂, foil, thickness 0.025 mm, 99.99% trace metals basis

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铂, foil, thickness 0.1 mm, 99.9% trace metals basis

铂, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

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铂, sponge, ≥99.9% trace metals basis