CN

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

摘要

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

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Sigma-Aldrich

铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis

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铂, wire, diam. 0.5 mm, 99.99% trace metals basis

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铂, gauze, 100 mesh, 99.9% trace metals basis

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铂, powder, 99.995% trace metals basis

Sigma-Aldrich

铂, wire, diam. 1.0 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, wire, diam. 2.0 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.025 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.25 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, gauze, 52 mesh, 99.9% trace metals basis

Sigma-Aldrich

铂黑, fuel cell grade, ≥99.9% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.5 mm, 99.9% trace metals basis

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铂, nanopowder, <50 nm particle size (TEM)

铂, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

铂, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

Sigma-Aldrich

铂, wire, diam. 0.25 mm, thermocouple grade

Sigma-Aldrich

铂黑, low bulk density, ≥99.9% trace metals basis

Sigma-Aldrich

铂, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, powder (coarse), 99.99% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.05 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.25 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, wire, diam. 0.076 mm, ≥99.99% trace metals basis

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铂, wire, diam. 0.127 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, sponge, ≥99.9% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.1 mm, 99.9% trace metals basis

Sigma-Aldrich

铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

Sigma-Aldrich

铂, wire, diam. 0.10 mm, 99.99% trace metals basis

铂, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.99+%

Sigma-Aldrich

铂, wire, diam. 0.25 mm, 99.99% trace metals basis

Sigma-Aldrich

铂, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

铂, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%