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显示 1-30 共 83 条结果 关于 "229857" 范围 论文
Thomas G Back et al.
Journal of the American Chemical Society, 124(41), 12104-12105 (2002-10-10)
1,2-Oxaselenolane Se-oxide is a novel cyclic seleninate ester that functions as a remarkably efficient glutathione peroxidase mimetic by catalyzing the reduction of tert-butyl hydroperoxide to tert-butyl alcohol in the presence of benzyl thiol. The seleninate ester can be conveniently generated
Jianguo Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 183-189 (2014-03-15)
In this study, we employed a one-step method to prepare selenium nanoparticles (SeNPs) decorated by the water-soluble derivative of Ganoderma lucidum polysaccharides (SPS). The SeNPs-SPS complexes were stable, and the diameter of the SeNPs was homogeneous at around 25 nm.
Loqman A Mohamed et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 427-438 (2014-09-17)
PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer's disease (AD), would help to understand its hepatotoxicity, its therapeutic effect, and improve the management of patients with
Noriko Harada et al.
Biomaterials, 35(27), 7800-7810 (2014-06-24)
Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and differentiating into several lineages. In regenerative medicine, their potential as a resource for tissue-replacement therapy is receiving much attention. However, transplanting MSCs to repair larger bone defects in animal
Xing-Long Zheng et al.
Biomedical materials (Bristol, England), 10(4), 045023-045023 (2015-08-21)
Using a decellularized liver matrix (DLM) to reengineer liver tissue is a promising therapy for end-stage liver disease. However, the limited supply of donor organs still hampers its potential clinical application, while a xenogenic decellularized matrix may bring a risk
M A Tariq et al.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 19(4), 423-429 (1992-05-01)
The distribution and retention of selenate and selenite in C57L/J mice was investigated using 75Se radioisotope. The comparison is made with the normal distribution of the element determined by using radioisotope-induced x-ray fluorescence, RIXRF methods. The distribution of the two
Eduardo Cemeli et al.
Teratogenesis, carcinogenesis, and mutagenesis, Suppl 2, 53-67 (2003-12-24)
Selenium is an environmental metal that occurs ubiquitously and is produced throughout the world for various industrial activities. Selenium has been reported to have anticarcinogenic and preventive effects in clinical and epidemiological studies. Selenium supplements can inhibit chemically-induced tumours. From
L Yan et al.
Cancer research, 52(20), 5803-5807 (1992-10-15)
Brief pre-exposure of HeLa cells to micromolar concentrations of selenite resulted in a dose-dependent decrease in the rate of their subsequent attachment to a solid matrix (tissue culture dish). Similar low concentrations of selenite also inhibited colony formation, but only
Kristen R Hladun et al.
Environmental toxicology and chemistry, 32(11), 2584-2592 (2013-10-12)
Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because of the biotransfer of Se from plant products such as
B A Labaran et al.
Environmental technology, 35(9-12), 1091-1100 (2014-04-08)
TiO2-assisted photocatalysis was employed for the removal of aqueous phase selenite and selenate species in conjunction with EDTA as a hole (h+) scavenger. Findings from the binary selenite/EDTA and selenate/EDTA systems showed high selenite and selenate removal at pH 4
Meghan K Murphy et al.
Cell transplantation, 24(2), 235-245 (2014-01-02)
Expanded costochondral cells provide a clinically relevant cell source for engineering both fibrous and hyaline articular cartilage. Expanding chondrocytes in a monolayer results in a shift toward a proliferative, fibroblastic phenotype. Three-dimensional aggregate culture may, however, be used to recover
Vincent van Drongelen et al.
Cell and tissue research, 361(3), 789-797 (2015-03-18)
Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein. Human skin equivalents (HSEs) might be
Takao Tobe et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 687-694 (2015-03-19)
Selenium (Se) is an essential antioxidative micronutrient but can exert cancer-selective cytotoxicity if the nutritional levels are too high. Selenodiglutathione (GSSeSG) is a primary Se metabolite conjugated with two glutathione (GSH) moieties. GSSeSG has been suggested to be an important
Takeshi Kobayashi et al.
Experimental eye research, 135, 109-117 (2015-02-17)
Interactions between stromal and epithelial cells play important roles in the development, homeostasis, and pathological conditions of the cornea. Soluble cytokines are critical factors in stromal-epithelial interactions, and growth factors secreted from corneal stromal cells contribute to the regulation of
Bo Wei et al.
Journal of biomaterials applications, 30(2), 160-170 (2015-03-15)
The goal of this study was to investigate the chondrogenic potential of three-dimensional polycaprolactone-hydroxyapatite (PCL-HA) scaffolds loaded with bone marrow cells in vitro and the effect of PCL-HA scaffolds on osteochondral repair in vivo. Here, bone marrow was added to
J F Nishimuta et al.
Osteoarthritis and cartilage, 23(9), 1551-1562 (2015-04-29)
This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA). Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, 0.2
Yuki Ohta et al.
Toxicology and applied pharmacology, 226(2), 169-177 (2007-11-09)
All nutritional selenium sources are transformed into the assumed common intermediate selenide for the syntheses of selenoproteins for utilization and/or of selenosugar for excretion. Methylselenol [monomethylselenide, MMSe] is the assumed intermediate leading to other methylated metabolites, dimethylselenide (DMSe) and trimethylselenonium
P Díaz et al.
Research in veterinary science, 99, 120-128 (2015-02-01)
Mesenchymal stem cells (MSC) are multipotent progenitor cells defined by their ability to self-renew and give rise to differentiated progeny. Since MSC from adult tissues represent a promising source of cells for a wide range of cellular therapies, there is
Alexander D Cigan et al.
Tissue engineering. Part A, 19(17-18), 1941-1948 (2013-04-03)
The primary goal of this study was to characterize the response of chondrocyte-seeded agarose constructs to varying concentrations of several key nutrients in a chondrogenic medium, within the overall context of optimizing the key nutrients and the placement of nutrient
Hidenari Nakayama et al.
Journal of bioscience and bioengineering, 117(6), 756-762 (2014-01-01)
We recently developed a polydimethylsiloxane (PDMS)-based three-compartment microfluidic cocultivation device enabling real-time interactions of different cell populations as an advanced physiologically-relevant cell-based assay. This device had valves and small magnetic stirrer-based internal pumps for easy and flexible perfusion operations. In
Wiberg E and Wiberg N
Inorganic Chemistry null
Iris L Kim et al.
Tissue engineering. Part A, 21(21-22), 2680-2690 (2015-09-25)
Current clinically approved methods for cartilage repair are generally based on either endogenous cell recruitment (e.g., microfracture) or chondrocyte delivery (e.g., autologous chondrocyte implantation). However, both methods culminate in repair tissue with inferior mechanical properties and the addition of biomaterials
Emilio Satoshi Hara et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(9), 1585-1596 (2015-03-11)
Articular cartilage repair remains a challenging problem. Based on a high-throughput screening and functional analysis, we found that fluocinolone acetonide (FA) in combination with transforming growth factor beta 3 (TGF-β3) strongly potentiated chondrogenic differentiation of human bone marrow-derived mesenchymal stem
Ying Zhang et al.
Biomaterials, 64, 88-97 (2015-07-01)
Autologous stem cells are a promising cell source for cartilage regeneration; however, cell replicative senescence and joint posttraumatic inflammation provide challenges in bringing this treatment modality to fruition. In this study, we hypothesized that preconditioning with p38 MAPK inhibitor (sb203580)
D A Quadrani et al.
Veterinary and human toxicology, 42(2), 96-98 (2000-04-06)
Acute selenium poisoning occurs infrequently. The form of selenium encountered plays a great role in toxicity. Several fatalities have been reported and all but I involved ingestion of selenious acid or selenium dioxide. A healthy 22-mo-old male ingested up to
Boram Son et al.
Advanced healthcare materials, 4(9), 1339-1347 (2015-04-08)
Chondrogenic commitments of mesenchymal stem cells (MSCs) require 3D cellular organization. Furthermore, recent progresses in bioreactor technology have contributed to the development of various biophysical stimulation platforms for efficient cartilage tissue formation. Here, an approach is reported to drive 3D
Dangerous in small amounts: ten nondrug substances that cause harm.
Dana Bartlett
Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association, 29(4), 377-379 (2003-07-23)
V Arjunan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 744-758 (2012-08-14)
The molecular complex of betaine with selenious acid namely, betaine dihydrogen selenite (C(5)H(13)NO(5)Se, BDHSe) was synthesised by the reaction of betaine and SeO(2) in a 1:1:1 solution of isopropanol, methanol and water. Crystals were grown from this solution by cooling
A Terada et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 11(2), 105-109 (1997-06-01)
The influence of the combined use of selenious acid and SH compounds (glutathione (GSH) and cysteine (Cys), or ascorbic acid (Asc)) on cultured venous vascular cells was investigated experimentally. When cultured human umbilical venous vascular endothelial cells were exposed to
Thomas G Back et al.
The Journal of organic chemistry, 70(23), 9230-9236 (2005-11-05)
[Reaction: see text]. Several novel organoselenium and tellurium compounds were prepared and evaluated as mimetics of the selenoenzyme glutathione peroxidase, which protects cells from oxidative stress by reducing harmful peroxides with the thiol glutathione. The compounds were tested for catalytic
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