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Rebecca Y Wang et al.
Annals of biomedical engineering, 45(7), 1807-1818 (2016-11-07)
Obesity is a rising issue especially in the United States that can lead to heart problems, type II diabetes, and respiratory problems. Since the 1970s, obesity rates in the United States have more than doubled in adults and children. Recent
Bachir Abi Salloum et al.
Toxicology and applied pharmacology, 268(3), 300-308 (2013-03-05)
Bisphenol-A (BPA), a polymer used in plastics manufacturing, and methoxychlor (MXC), a pesticide, are endocrine disrupting compounds with estrogenic and anti-androgenic properties. Prenatal BPA or MXC treatment induces reproductive defects in sheep with BPA causing prepubertal luteinizing hormone (LH) hypersecretion
Ying Jiang et al.
Toxicology letters, 228(2), 85-92 (2014-04-29)
An emerging literature suggests that bisphenol A (BPA), a widespread endocrine disrupting chemical, when exposure occurs in early life, may increase the risk of metabolic syndrome. In this study, we investigated the hypothesis that perinatal exposure to BPA predisposed offspring
Arunoday Bhan et al.
The Journal of steroid biochemistry and molecular biology, 141, 160-170 (2014-02-19)
Antisense transcript, long non-coding RNA HOTAIR is a key player in gene silencing and breast cancer and is transcriptionally regulated by estradiol. Here, we have investigated if HOTAIR expression is misregulated by bisphenol-A (BPA) and diethylstilbestrol (DES). Our findings demonstrate
Germaine M Buck Louis et al.
Fertility and sterility, 100(1), 162-169 (2013-04-13)
To explore the relation between bisphenol A and 14 phthalate metabolites and endometriosis. Matched cohort design. Fourteen clinical centers. The operative cohort comprised 495 women undergoing laparoscopy/laparotomy, whereas the population cohort comprised 131 women matched on age and residence. None.
Priyadarshini Mirmira et al.
Translational research : the journal of laboratory and clinical medicine, 164(1), 13-21 (2014-04-02)
Bisphenol A (BPA) is a ubiquitous industrial chemical found in a variety of plastic containers intended for food storage and in the epoxy resin linings of metal food and beverage cans, where it is used to prevent corrosion, food contamination
Sergiane Souza Caldas et al.
Talanta, 146, 676-688 (2015-12-24)
A rapid and efficient sample pretreatment using solvent-based de-emulsification dispersive liquid-liquid microextraction (SD-DLLME) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was studied for the extraction of 58 pharmaceuticals and personal care products (PPCPs) and pesticides from water samples. Type and
Teng Zhang et al.
Environmental and molecular mutagenesis, 55(4), 343-353 (2014-01-25)
Bisphenol-A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such compounds have adverse effects on various aspects of mammalian reproduction including folliculogenesis. The objective of this study
Marco Pellegrini et al.
Journal of cellular physiology, 229(8), 1061-1068 (2013-12-19)
Sex steroid hormones differently control the major physiological processes in male and female organisms. In particular, their effects on vascular smooth muscle cells (VSMCs) migration are at the root of sex/gender-related differences reported in the cardiovascular system. Several exogenous substances
Steven L Neese et al.
Neurotoxicology and teratology, 35, 46-53 (2013-01-24)
Over 90% of the U.S. population has detectable bisphenol-A (BPA) in their urine according to recent biomonitoring data. BPA is best known for its estrogenic properties, and most rodent research on the nervous system effects of BPA has focused on
Ruchi Bhandari et al.
American journal of epidemiology, 177(11), 1263-1270 (2013-04-06)
Childhood obesity, a major public health problem, can lead to cardiovascular disease in adulthood. Studies have implicated exposure to bisphenol A (BPA), a commonly used chemical, in the development of obesity in adults. However, literature is limited on this association
C Noutsopoulos et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(7), 1551-1556 (2013-04-05)
Endocrine disrupting chemicals (EDCs) are compounds of mainly anthropogenic origin that interfere with the endocrine system of animals and humans thus causing a series of disorders. Wastewater treatment plants are one of the major routes for transporting such chemicals to
Brendan J Holland et al.
Analytica chimica acta, 842, 35-41 (2014-08-17)
Sodium polyphosphate is commonly used to enhance chemiluminescence reactions with acidic potassium permanganate through a dual enhancement mechanism, but commercially available polyphosphates vary greatly in composition. We have examined the influence of polyphosphate composition and concentration on both the dual
Xin Xu et al.
Molecular carcinogenesis, 54(2), 134-147 (2013-09-07)
Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10). Human FBXO10, an evolutionarily conserved ubiquitin
Rajesh Kumar et al.
Journal of chromatography. A, 1359, 16-25 (2014-08-02)
A simple, fast and sensitive analytical method using fabric phase sorptive extraction (FPSE) followed by high performance liquid chromatography with fluorescence detection (HPLC-FLD) has been developed for efficient quantification of biologically important molecules e.g., 17α-ethynylestradiol (EE2), β-estradiol (E2) and bisphenol
Wei Wang et al.
Toxicology and applied pharmacology, 276(2), 157-164 (2014-03-01)
Bisphenol A (BPA) is a known reproductive toxicant in rodents. However, the effects of in utero BPA exposure on early ovarian development and the consequences of such exposure on female reproduction in later reproductive life are unclear. Thus, we determined
Ravindranath Reddy Gilibili et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(1), 26-39 (2014-04-23)
There is a growing body of evidence that exposure to endocrine disrupting chemicals and to estrogenic compounds in particular can affect the testis and male fertility. In the present study, the constitutive expression of steroidogenic and non-steroidogenic cytochrome P450 (CYP)
L K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 193, 29-36 (2014-07-06)
Pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) enter the soil environment via irrigation with treated wastewater, groundwater recharge, and land application of biosolids. The transformation and fate of PPCP/EDCs in soil affects their potential for plant
Xu-Liang Cao et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 2154-2160 (2015-09-16)
Food composite samples from the Canadian Total Diet Study which was conducted each year from 2008 to 2012 rotating between different cities were analysed for bisphenol A (BPA). The overall levels of BPA in the composite food samples from each
Jingjing Yang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(8), 1867-1872 (2013-04-13)
The kinetics for reaction between bisphenol A (BPA) and permanganate was examined over pH range of 5.0-9.9 and the estrogenic activity of aqueous BPA solution after oxidation was assessed by yeast two-hybrid assay. Reaction kinetics follows the second-order rate law
Arpita Kalla Vyas et al.
Journal of applied toxicology : JAT, 39(11), 1516-1531 (2019-07-25)
In both human and animals, in utero exposure to bisphenol A (BPA), an endocrine-disrupting chemical used in the production of plastics and epoxy resins, has been shown to affect offspring reproductive and metabolic health during adult life. We hypothesized that
Richard Mark Evans et al.
PloS one, 7(8), e43606-e43606 (2012-08-23)
A growing body of experimental evidence indicates that the in vitro effects of mixtures of estrogenic chemicals can be well predicted from the estrogenicity of their components by the concentration addition (CA) concept. However, some studies have observed small deviations
Almudena Veiga-Lopez et al.
Endocrinology, 154(5), 1873-1884 (2013-03-26)
Bisphenol-A (BPA), a ubiquitous environmental endocrine disrupting chemical, is a component of polycarbonate plastic and epoxy resins. Because of its estrogenic properties, there is increasing concern relative to risks from exposures during critical periods of early organ differentiation. Prenatal BPA
Andreas Bitter et al.
Archives of toxicology, 89(11), 2089-2103 (2014-09-04)
In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent activation and knockout of PXR were previously shown to promote hepatic
A high throughput screening system for predicting chemically-induced reproductive organ deformities.
Bart van der Burg et al.
Reproductive toxicology (Elmsford, N.Y.), 55, 95-103 (2014-12-22)
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals
Sanghyuk Bae et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 313-319 (2014-12-10)
Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of
Beata Wyżga et al.
Colloids and surfaces. B, Biointerfaces, 186, 110670-110670 (2019-12-10)
Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. The aim
Ruth B Lathi et al.
Fertility and sterility, 102(1), 123-128 (2014-04-22)
To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk. Retrospective cohort of prospectively collected serum samples. Academic fertility center. Women presenting for early pregnancy monitoring with
Albert J Thayil et al.
Biology of reproduction, 103(6), 1324-1335 (2020-09-18)
Endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and 17α-ethinylestradiol (EE2), can have far reaching health effects, including transgenerational abnormalities in offspring that never directly contacted either chemical. We previously reported reduced fertilization rates and embryo survival at F2
Xiaoli Wang et al.
The Journal of endocrinology, 221(2), 201-213 (2014-02-18)
Bisphenol-A (BPA), an environmental estrogen, adversely affects female reproductive health. However, the underlying mechanisms remain largely unknown. We found that oral administration (p.o.) of BPA (20 μg/kg) to adult female mice at proestrus, but not at estrus or diestrus, significantly
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