30501

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Chemical hazards present in liquids and vapors of electronic cigarettes.

Christoph Hutzler et al.

Archives of toxicology, 88(7), 1295-1308 (2014-06-25)

Electronic (e-)cigarettes have emerged in recent years as putative alternative to conventional tobacco cigarettes. These products do not contain typical carcinogens that are present in tobacco smoke, due to the lack of combustion. However, besides nicotine, hazards can also arise

Mitigation of signal suppression caused by the use of trifluoroacetic acid in liquid chromatography mobile phases during liquid chromatography/mass spectrometry analysis via post-column addition of ammonium hydroxide.

Chang-Ching Chan et al.

Rapid communications in mass spectrometry : RCM, 26(12), 1507-1514 (2012-05-18)

A method has been developed to reduce the mass spectrometric ion signal suppression associated with the use of TFA as an additive in LC mobile phases. Through post-column infusion of diluted NH(4)OH solution to LC eluents, the ammonium ion introduced

Surfactant-assisted sol-gel synthesis of forsterite nanoparticles as a novel drug delivery system.

S A Hassanzadeh-Tabrizi et al.

Materials science & engineering. C, Materials for biological applications, 58, 737-741 (2015-10-20)

In the present study, forsterite nanoparticles were synthesized via surfactant-assisted sol-gel method using cetyltrimethyl ammonium bromide (CTAB) as a surfactant. The effects of CTAB contents and heat treatment on the textural properties and drug release from nanoparticles were investigated. The

RNAscope dual ISH-IHC technology to study angiogenesis in diffuse large B-cell lymphomas.

Tiziana Annese et al.

Histochemistry and cell biology, 153(3), 185-192 (2019-12-18)

Diffuse large B-cell lymphomas (DLBCLs) are the most common types of Non-Hodgkin's lymphomas and are highly heterogeneous in terms of phenotype and treatment response. The natural course of DLBCLs tumor progression is featured by a flow of events leading to

Nanoscale-supported heteropoly acid as a new fiber coating for solid-phase microextraction coupled with gas chromatography-mass spectrometry.

Mir Mahdi Abolghasemi et al.

Journal of chromatography. A, 1381, 48-53 (2015-01-27)

In the present study, 12-tungstophosphoric (PW) acid as heteropoly acid, supported on silica-coated γ-Fe2O3 nanoparticles (NPs), was used as a new fiber coating for solid-phase microextraction (SPME). The γ-Fe2O3@SiO2-PW nanocomposite with high surface area was synthesized and characterized by SEM

Differential deposition of fibronectin by asthmatic bronchial epithelial cells.

Qi Ge et al.

American journal of physiology. Lung cellular and molecular physiology, 309(10), L1093-L1102 (2015-09-06)

Altered ECM protein deposition is a feature in asthmatic airways. Fibronectin (Fn), an ECM protein produced by human bronchial epithelial cells (HBECs), is increased in asthmatic airways. This study investigated the regulation of Fn production in asthmatic or nonasthmatic HBECs

Enantioseparation of (DL)-tryptophan by spiral tube assembly counter-current chromatography and evaluation of mass transfer rate for enantiomers.

Shengqiang Tong et al.

Journal of chromatography. A, 1374, 77-84 (2014-12-06)

Spiral tube assembly counter-current chromatography was successfully applied in enantioseparation of dl-tryptophan using bovine serum albumin as chiral selector. An improved biphasic aqueous-aqueous solvent system 12.0% (w/w) polyethyleneglycol 8000-9.0% (w/w) dibasic potassium phosphate-0.1% ammonia-78.9% water was used as the solvent

Rapid quantitative chiral amphetamines liquid chromatography-tandem mass spectrometry: method in plasma and oral fluid with a cost-effective chiral derivatizing reagent.

Matthew N Newmeyer et al.

Journal of chromatography. A, 1358, 68-74 (2014-07-30)

Methamphetamine is a widely abused psychostimulant containing a chiral center. Consumption of over-the-counter and prescription medications may yield positive amphetamines results, but chiral separation of l- and d-methamphetamine and its metabolite amphetamine can help determine whether the source was licit

Rapid determination of thiamine, riboflavin, niacinamide, pantothenic acid, pyridoxine, folic acid and ascorbic acid in Vitamins with Minerals Tablets by high-performance liquid chromatography with diode array detector.

Pengfei Jin et al.

Journal of pharmaceutical and biomedical analysis, 70, 151-157 (2012-07-13)

A simple, isocratic, and stability-indicating high-performance liquid chromatography (HPLC) method has been developed for the rapid determination of thiamine (VB(1)), niacinamide (VB(3)), pyridoxine (VB(6)), ascorbic acid (VC), pantothenic acid (VB(5)), riboflavin (VB(2)) and folic acid (VB(9)) in Vitamins with Minerals

Cr(VI) speciation in foods by HPLC-ICP-MS: investigation of Cr(VI)/food interactions by size exclusion and Cr(VI) determination and stability by ion-exchange on-line separations.

Véronique Vacchina et al.

Analytical and bioanalytical chemistry, 407(13), 3831-3839 (2015-03-17)

A method has been developed for the specific and sensitive determination of Cr(VI) in foods. First, the interactions between Cr(VI) and the matrices were investigated by size-exclusion HPLC-ICP-MS (SEC-ICP-MS). Evidence was found for the complexation of Cr(VI) potentially present with

Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13.

Matt Hrapchak et al.

Journal of labelled compounds & radiopharmaceuticals, 57(12), 687-694 (2014-10-22)

Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of carbon-13 and carbon-14 labeled empagliflozin. Carbon-13 labeled empagliflozin was prepared in five steps and in 34% overall

Quantitation of methadone and metabolite in patients under maintenance treatment.

Shiau Hui Diong et al.

Journal of analytical toxicology, 38(9), 660-666 (2014-08-12)

Gas chromatography-mass spectrometry quantitative method was developed to monitor concentrations of methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in plasma and urine of patients. The developed method was simple, accurate and reproducible to quantify methadone and EDDP in plasma and urine

Effect of electrolyte pH on CIEF with narrow pH range ampholytes.

Csilla Páger et al.

Electrophoresis, 33(22), 3269-3275 (2012-10-23)

CIEF of components following sequential injection of ampholytes and the sample zone offers unique advantages for analysis. The most important one of these is the efficient separation of amphoteric compounds having pIs outside the pH range of the ampholytes applied

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Alexandr N Simonov et al.

PloS one, 10(11), e0141252-e0141252 (2015-11-21)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by

Photochemically induced intramolecular six-electron reductive elimination and oxidative addition of nitric oxide by the nitridoosmate(VIII) anion.

Wyatt A Thornley et al.

Angewandte Chemie (International ed. in English), 54(7), 2068-2072 (2014-12-30)

UV photolysis of the nitridoosmate(VIII) anion, OsO3 N(-) , in low-temperature frozen matrices results in nitrogen-oxygen bond formation to give the Os(II) nitrosyl complex OsO2 (NO)(-) . Photolysis of the Os(II) nitrosyl product with visible wavelengths results in reversion to

Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine.

Miranda G M Kok et al.

Talanta, 132, 1-7 (2014-12-06)

In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic interaction chromatography-MS (HILIC-MS) using negative electrospray ionization. After optimization of the

Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry.

Gilles Provencher et al.

Journal of chromatography. A, 1348, 97-104 (2014-05-20)

Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former

Targeted and highly multiplexed detection of microorganisms by employing an ensemble of molecular probes.

Weihong Xu et al.

Applied and environmental microbiology, 80(14), 4153-4161 (2014-05-06)

The vast majority of microscopic life on earth consists of microbes that do not grow in laboratory culture. To profile the microbial diversity in environmental and clinical samples, we have devised and employed molecular probe technology, which detects and identifies

Preparation and application of crosslinked poly(sodium acrylate)--coated magnetite nanoparticles as corrosion inhibitors for carbon steel alloy.

Ayman M Atta et al.

Molecules (Basel, Switzerland), 20(1), 1244-1261 (2015-01-17)

This work presents a new method to prepare poly(sodium acrylate) magnetite composite nanoparticles. Core/shell type magnetite nanocomposites were synthesized using sodium acrylate as monomer and N,N-methylenebisacrylamide (MBA) as crosslinker. Microemulsion polymerization was used for constructing core/shell structures with magnetite nanoparticles

Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.

Erin Gemperline et al.

Analytical methods : advancing methods and applications, 6(16), 6389-6396 (2015-02-11)

(RS)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) is a competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and is routinely used with rodent models to investigate the role of NMDA receptors in brain function. This highly polar compound is difficult to separate from biological matrices.

Extraction parameters for metabolomics from cultured cells.

Zheng Ser et al.

Analytical biochemistry, 475, 22-28 (2015-01-24)

The successful extraction of metabolites is a critical step in metabolite profiling. By optimizing metabolite extraction, the range and quantitative capacity of metabolomics studies can be improved. We considered eight separate extraction protocols for the preparation of a metabolite extract

Simultaneous quantification of three active alkaloids from a traditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography-tandem mass spectrometry.

Shuang Yang et al.

Journal of pharmaceutical and biomedical analysis, 109, 177-183 (2015-03-18)

Fagomine, 1-deoxynojirimycin (DNJ) and 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) are the major bioactive constituents in the active fraction of alkaloids from the traditional Chinese medicine mulberry twig (Ramulus Mori, Chinese name Sang Zhi), which has a strong activity on α-glucosidase in vitro and

High-throughput tandem mass spectrometry multiplex analysis for newborn urinary screening of creatine synthesis and transport disorders, Triple H syndrome and OTC deficiency.

Christiane Auray-Blais et al.

Clinica chimica acta; international journal of clinical chemistry, 436, 249-255 (2014-06-10)

Creatine synthesis and transport disorders, Triple H syndrome and ornithine transcarbamylase deficiency are treatable inborn errors of metabolism. Early screening of patients was found to be beneficial. Mass spectrometry analysis of specific urinary biomarkers might lead to early detection and

Pretreatment of sugarcane bagasse with NH4OH-H2O2 and ionic liquid for efficient hydrolysis and bioethanol production.

Zhisheng Zhu et al.

Bioresource technology, 119, 199-207 (2012-06-26)

An efficient pretreatment method using NH(4)OH-H(2)O(2) and ionic liquid (IL) was developed for the recovery of cellulose from sugarcane bagasse (SCB). The regenerated SCB from the combined pretreatment exhibited significantly enhanced enzymatic digestibility with an efficiency of 91.4% after 12h

Fast separation of selected cathinones and phenylethylamines by supercritical fluid chromatography.

Volodymyr Pauk et al.

Journal of chromatography. A, 1423, 169-176 (2015-11-21)

The chromatographic behaviour of eleven synthetic cathinones and four phenylethylamines under supercritical/subcritical fluid conditions was investigated. Four stationary phases with sub-2μm particles (Waters Acquity UPC(2) BEH silica, BEH 2-ethylpyridine, CSH Fluoro-Phenyl, and HSS C18SB) were evaluated in terms of isomer

Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites.

Rong Zhang et al.

Journal of chromatography. A, 1362, 168-179 (2014-08-28)

It has been reported that HILIC column chemistry has a great effect on the number of detected metabolites in LC-HRMS-based untargeted metabolite profiling studies. However, no systematic investigation has been carried out with regard to the optimisation of mobile phase

Effects of succinate and pH on cooked beef color.

R Ramanathan et al.

Meat science, 93(4), 888-892 (2013-01-15)

Two experiments were conducted to assess the effects of succinate and pH on cooked beef color. In experiment 1, ten strip loins (M. longissimus lumborum) were divided in half and assigned to either non-enhanced control or 2.5% succinate. Each half-loin

Silver electrocrystallization on vitreous carbon from ammonium hydroxide solutions.

Palomar-Pardave M, et al.

Journal of the Electrochemical Society, 143(5), 1551-1558 (1996)

Hybrid organic-inorganic colloidal composite 'sponges' via internal crosslinking.

Bradley Duncan et al.

Small (Weinheim an der Bergstrasse, Germany), 11(11), 1302-1309 (2014-11-11)

An effective method for the generation of hybrid organic-inorganic nanocomposite microparticles featuring controlled size and high structural stability is presented. In this process, an oil-in-water Pickering emulsion is formed using hydrophilic amine-functionalized silica nanoparticles. Covalent modification using a hydrophobic maleic

Three-dimensional block copolymer nanostructures by the solvent-annealing-induced wetting in anodic aluminum oxide templates.

Chiang-Jui Chu et al.

Macromolecular rapid communications, 35(18), 1598-1605 (2014-08-08)

Block copolymers have been extensively studied over the last few decades because they can self-assemble into well-ordered nanoscale structures. The morphologies of block copolymers in confined geometries, however, are still not fully understood. In this work, the fabrication and morphologies

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