338818

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Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine.

Miranda G M Kok et al.

Talanta, 132, 1-7 (2014-12-06)

In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic interaction chromatography-MS (HILIC-MS) using negative electrospray ionization. After optimization of the

Cr(VI) speciation in foods by HPLC-ICP-MS: investigation of Cr(VI)/food interactions by size exclusion and Cr(VI) determination and stability by ion-exchange on-line separations.

Véronique Vacchina et al.

Analytical and bioanalytical chemistry, 407(13), 3831-3839 (2015-03-17)

A method has been developed for the specific and sensitive determination of Cr(VI) in foods. First, the interactions between Cr(VI) and the matrices were investigated by size-exclusion HPLC-ICP-MS (SEC-ICP-MS). Evidence was found for the complexation of Cr(VI) potentially present with

Rapid quantitative chiral amphetamines liquid chromatography-tandem mass spectrometry: method in plasma and oral fluid with a cost-effective chiral derivatizing reagent.

Matthew N Newmeyer et al.

Journal of chromatography. A, 1358, 68-74 (2014-07-30)

Methamphetamine is a widely abused psychostimulant containing a chiral center. Consumption of over-the-counter and prescription medications may yield positive amphetamines results, but chiral separation of l- and d-methamphetamine and its metabolite amphetamine can help determine whether the source was licit

Chemical hazards present in liquids and vapors of electronic cigarettes.

Christoph Hutzler et al.

Archives of toxicology, 88(7), 1295-1308 (2014-06-25)

Electronic (e-)cigarettes have emerged in recent years as putative alternative to conventional tobacco cigarettes. These products do not contain typical carcinogens that are present in tobacco smoke, due to the lack of combustion. However, besides nicotine, hazards can also arise

Mitigation of signal suppression caused by the use of trifluoroacetic acid in liquid chromatography mobile phases during liquid chromatography/mass spectrometry analysis via post-column addition of ammonium hydroxide.

Chang-Ching Chan et al.

Rapid communications in mass spectrometry : RCM, 26(12), 1507-1514 (2012-05-18)

A method has been developed to reduce the mass spectrometric ion signal suppression associated with the use of TFA as an additive in LC mobile phases. Through post-column infusion of diluted NH(4)OH solution to LC eluents, the ammonium ion introduced

Plasma metabolite profiling and chemometric analyses of lung cancer along with three controls through gas chromatography-mass spectrometry.

Syed Ghulam Musharraf et al.

Scientific reports, 5, 8607-8607 (2015-02-26)

Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers

Detection and in vitro metabolism of AOD9604.

Holly D Cox et al.

Drug testing and analysis, 7(1), 31-38 (2014-09-12)

AOD9604 is a peptide consisting of the C-terminal fragment of human growth hormone from amino acids 177-191 with an additional tyrosine residue at the N-terminus of the peptide. It is reported to mimic the lipolytic properties of growth hormone without

Ion exchange membranes as novel passive sampling material for organic ions: application for the determination of freely dissolved concentrations.

Luise Oemisch et al.

Journal of chromatography. A, 1370, 17-24 (2014-12-03)

Many studies in pharmacology, toxicology and environmental science require a method for determining the freely dissolved concentration of a target substance. A recently developed tool for this purpose is equilibrium passive sampling with polymeric materials. However, this method has rarely

Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles.

Stefan Harmsen et al.

Nature protocols, 12(7), 1400-1414 (2017-07-08)

The unique spectral signatures and biologically inert compositions of surface-enhanced resonance Raman scattering (SERRS) nanoparticles make them promising contrast agents for in vivo cancer imaging. Our SERRS nanoparticles consist of a 60-nm gold nanoparticle core that is encapsulated in a

Biscationic Tartaric Acid-Based Amphiphiles: Charge Location Impacts Antimicrobial Activity.

Allison Faig et al.

Langmuir : the ACS journal of surfaces and colloids, 31(43), 11875-11885 (2015-10-22)

Cationic amphiphiles have received increasing attention as antimicrobials given their unique ability to disrupt bacteria cell membranes. While extensive research has demonstrated that amphiphiles' hydrophobic-to-charge ratio significantly modulates antibacterial activity, less work has focused on elucidating the specific impact of

Nanoscale-supported heteropoly acid as a new fiber coating for solid-phase microextraction coupled with gas chromatography-mass spectrometry.

Mir Mahdi Abolghasemi et al.

Journal of chromatography. A, 1381, 48-53 (2015-01-27)

In the present study, 12-tungstophosphoric (PW) acid as heteropoly acid, supported on silica-coated γ-Fe2O3 nanoparticles (NPs), was used as a new fiber coating for solid-phase microextraction (SPME). The γ-Fe2O3@SiO2-PW nanocomposite with high surface area was synthesized and characterized by SEM

Differential deposition of fibronectin by asthmatic bronchial epithelial cells.

Qi Ge et al.

American journal of physiology. Lung cellular and molecular physiology, 309(10), L1093-L1102 (2015-09-06)

Altered ECM protein deposition is a feature in asthmatic airways. Fibronectin (Fn), an ECM protein produced by human bronchial epithelial cells (HBECs), is increased in asthmatic airways. This study investigated the regulation of Fn production in asthmatic or nonasthmatic HBECs

Enantioseparation of (DL)-tryptophan by spiral tube assembly counter-current chromatography and evaluation of mass transfer rate for enantiomers.

Shengqiang Tong et al.

Journal of chromatography. A, 1374, 77-84 (2014-12-06)

Spiral tube assembly counter-current chromatography was successfully applied in enantioseparation of dl-tryptophan using bovine serum albumin as chiral selector. An improved biphasic aqueous-aqueous solvent system 12.0% (w/w) polyethyleneglycol 8000-9.0% (w/w) dibasic potassium phosphate-0.1% ammonia-78.9% water was used as the solvent

Modified mesoporous silica materials for on-line separation and preconcentration of hexavalent chromium using a microcolumn coupled with flame atomic absorption spectrometry.

Zheng Wang et al.

Analytica chimica acta, 725, 81-86 (2012-04-17)

A modified SBA-15 mesoporous silica material NH(2)-SBA-15 was synthesized successfully by grafting γ-aminopropyl-triethoxysilane. The material was characterized using transmission electron microscopy (TEM) and Fourier transform infrared/Raman (FT-IR/Raman) spectroscopy, and used for the first time in a flow injection on-line solid

Rapid determination of thiamine, riboflavin, niacinamide, pantothenic acid, pyridoxine, folic acid and ascorbic acid in Vitamins with Minerals Tablets by high-performance liquid chromatography with diode array detector.

Pengfei Jin et al.

Journal of pharmaceutical and biomedical analysis, 70, 151-157 (2012-07-13)

A simple, isocratic, and stability-indicating high-performance liquid chromatography (HPLC) method has been developed for the rapid determination of thiamine (VB(1)), niacinamide (VB(3)), pyridoxine (VB(6)), ascorbic acid (VC), pantothenic acid (VB(5)), riboflavin (VB(2)) and folic acid (VB(9)) in Vitamins with Minerals

The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans.

Nicholas A Burd et al.

Journal of applied physiology (Bethesda, Md. : 1985), 117(11), 1363-1370 (2014-10-04)

We aimed to determine the impact of precursor pool dilution on the assessment of postprandial myofibrillar protein synthesis rates (MPS). A Holstein dairy cow was infused with large amounts of L-[1-(13)C]phenylalanine and L-[1-(13)C]leucine, and the milk was collected and fractionated.

A fibrin antibody binding to fibronectin induces potent inhibition of angiogenesis.

Fida El-Ayoubi et al.

Thrombosis and haemostasis, 113(1), 143-153 (2014-09-26)

Antiserum from rabbits immunised with pure human fibrinogen was affinity purified on immobilised fibrin fragment E (FFE). This FFE antibody (Ab) induced significant growth inhibition of a human cancer xenograft in mice and suppression of tumour angiogenesis, leaving no formed

Quantitation of methadone and metabolite in patients under maintenance treatment.

Shiau Hui Diong et al.

Journal of analytical toxicology, 38(9), 660-666 (2014-08-12)

Gas chromatography-mass spectrometry quantitative method was developed to monitor concentrations of methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in plasma and urine of patients. The developed method was simple, accurate and reproducible to quantify methadone and EDDP in plasma and urine

Surfactant-assisted sol-gel synthesis of forsterite nanoparticles as a novel drug delivery system.

S A Hassanzadeh-Tabrizi et al.

Materials science & engineering. C, Materials for biological applications, 58, 737-741 (2015-10-20)

In the present study, forsterite nanoparticles were synthesized via surfactant-assisted sol-gel method using cetyltrimethyl ammonium bromide (CTAB) as a surfactant. The effects of CTAB contents and heat treatment on the textural properties and drug release from nanoparticles were investigated. The

Spike processing with a graphene excitable laser.

Bhavin J Shastri et al.

Scientific reports, 6, 19126-19126 (2016-01-13)

Novel materials and devices in photonics have the potential to revolutionize optical information processing, beyond conventional binary-logic approaches. Laser systems offer a rich repertoire of useful dynamical behaviors, including the excitable dynamics also found in the time-resolved "spiking" of neurons.

Preparation and application of crosslinked poly(sodium acrylate)--coated magnetite nanoparticles as corrosion inhibitors for carbon steel alloy.

Ayman M Atta et al.

Molecules (Basel, Switzerland), 20(1), 1244-1261 (2015-01-17)

This work presents a new method to prepare poly(sodium acrylate) magnetite composite nanoparticles. Core/shell type magnetite nanocomposites were synthesized using sodium acrylate as monomer and N,N-methylenebisacrylamide (MBA) as crosslinker. Microemulsion polymerization was used for constructing core/shell structures with magnetite nanoparticles

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Tao Xu et al.

The EMBO journal, 36(21), 3232-3249 (2017-10-17)

Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the nucleus and forms a complex with the transcription factor RBPJ (also known as

Urine Mescaline Screening With a Biochip Array Immunoassay and Quantification by Gas Chromatography-Mass Spectrometry.

Dilek Battal et al.

Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)

Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative

Targeted and highly multiplexed detection of microorganisms by employing an ensemble of molecular probes.

Weihong Xu et al.

Applied and environmental microbiology, 80(14), 4153-4161 (2014-05-06)

The vast majority of microscopic life on earth consists of microbes that do not grow in laboratory culture. To profile the microbial diversity in environmental and clinical samples, we have devised and employed molecular probe technology, which detects and identifies

High-speed Raman-encoded molecular imaging of freshly excised tissue surfaces with topically applied SERRS nanoparticles.

Yu Winston Wang et al.

Journal of biomedical optics, 23(4), 1-8 (2018-04-17)

Surface-enhanced Raman scattering (SERS) nanoparticles (NPs) are increasingly being engineered for a variety of disease-detection and treatment applications. For example, we have previously developed a fiber-optic Raman-encoded molecular imaging (REMI) system for spectral imaging of biomarker-targeted SERS NPs topically applied

Effect of electrolyte pH on CIEF with narrow pH range ampholytes.

Csilla Páger et al.

Electrophoresis, 33(22), 3269-3275 (2012-10-23)

CIEF of components following sequential injection of ampholytes and the sample zone offers unique advantages for analysis. The most important one of these is the efficient separation of amphoteric compounds having pIs outside the pH range of the ampholytes applied

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Alexandr N Simonov et al.

PloS one, 10(11), e0141252-e0141252 (2015-11-21)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by

Photochemically induced intramolecular six-electron reductive elimination and oxidative addition of nitric oxide by the nitridoosmate(VIII) anion.

Wyatt A Thornley et al.

Angewandte Chemie (International ed. in English), 54(7), 2068-2072 (2014-12-30)

UV photolysis of the nitridoosmate(VIII) anion, OsO3 N(-) , in low-temperature frozen matrices results in nitrogen-oxygen bond formation to give the Os(II) nitrosyl complex OsO2 (NO)(-) . Photolysis of the Os(II) nitrosyl product with visible wavelengths results in reversion to

Health risk assessment of arsenic exposure among the residents in Ndilǫ, Dettah, and Yellowknife, Northwest Territories, Canada.

Janet Sze-Jing Cheung et al.

International journal of hygiene and environmental health, 230, 113623-113623 (2020-09-16)

There are concerns in Yellowknife, Northwest Territories, Canada, about arsenic exposure due to past mining operations, particularly the former Giant Mine. The objective of this study was to characterize the risk of arsenic exposure and associated risk factors among the

Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.

Erin Gemperline et al.

Analytical methods : advancing methods and applications, 6(16), 6389-6396 (2015-02-11)

(RS)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) is a competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and is routinely used with rodent models to investigate the role of NMDA receptors in brain function. This highly polar compound is difficult to separate from biological matrices.

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