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34863
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Antonio J Villatoro et al.
BioMed research international, 2015, 527926-527926 (2015-03-25)
Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs)
Michael Oster et al.
PloS one, 10(3), e0120153-e0120153 (2015-03-21)
Defining phenotypes according to molecular features would promote the knowledge of functional traits like behaviour in both human and animal research. Beside physiological states or environmental factors, an innate predisposition of individual coping strategies was discussed, including the proactive and
Son T Nguyen et al.
Bioorganic & medicinal chemistry, 23(9), 2024-2034 (2015-03-31)
Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[3,4-c]pyridine) is structurally distinct from other known Gram-negative efflux pump inhibitors (EPIs), such as 1-(1-naphthylmethyl)-piperazine (NMP), phenylalanylarginine-β-naphthylamide (PAβN), D13-9001, and the pyridopyrimidine derivatives. Here
C Saal et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 1-11 (2015-02-15)
Cilengitide (Cil) represents a cyclic pentapeptide, cyclo-(Arg-Gly-Asp-D-Phe-N-MeVal). Existence of an anhydrate form (A1) and a tetrahydrate form Cil1(H2O)4 has been observed. Surprisingly the anhydrate form proved to be more stable in aqueous environment compared to the tetrahydrate form. Assessment of
Davy Baudelet et al.
Journal of chromatography. A, 1363, 257-269 (2014-07-21)
Analytical enantioseparation of three pyroglutamide derivatives with pharmacological activity against the purinergic receptor P2X7, was run in both high-performance liquid chromatography and supercritical fluid chromatography. Four polysaccharide based chiral stationary phases, namely amylose and cellulose tris (3,5-dimethylphenylcarbamate), amylose tris ((S)-α-methylbenzylcarbamate)
Jun Cao et al.
Electrophoresis, 34(2), 324-330 (2012-11-20)
A novel additive of multi-walled carbon nanotubes (MWNTs) dispersed with cationic surfactants or mixed cationic/anionic surfactants was used for MEEKC separation of eight phenolic compounds, four glycosides, and one phenanthraquinone. In this context, several parameters affecting MEEKC separation were studied
Halina Abramczyk et al.
The Analyst, 140(7), 2224-2235 (2015-03-03)
We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We demonstrate the first application of Raman imaging and spectroscopy in diagnosing the role of lipid droplets in cell line
Christian Brion et al.
BMC genomics, 15, 1085-1085 (2014-12-17)
Thiamine availability is involved in glycolytic flux and fermentation efficiency. A deficiency of this vitamin may be responsible for sluggish fermentations in wine making. Therefore, both thiamine uptake and de novo synthesis could have key roles in fermentation processes. Thiamine
Anna Gadaj et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 105-115 (2014-05-06)
An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their corresponding hydroxy metabolites (HMMNI, ipronidazile-OH and metronidazole-OH) in aquaculture tissue. Samples were extracted by shaking in acetonitrile
Christoph Roderburg et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1172-1184 (2014-07-22)
Serum concentrations of miR-122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in miR-122 serum levels are unknown. We analysed miR-122 serum levels and hepatic miR-122 expression in mice after hepatic ischaemia and reperfusion
Kelly R Stewart et al.
PloS one, 9(2), e88138-e88138 (2014-02-08)
For vertebrates with temperature-dependent sex determination, primary (or hatchling) sex ratios are often skewed, an issue of particular relevance to concerns over effects of climate change on populations. However, the ratio of breeding males to females, or the operational sex
Rui Yang et al.
Analytical and bioanalytical chemistry, 407(3), 737-747 (2014-07-12)
Microfluidic systems with monolithic columns have been developed for preconcentration and on-chip labeling of model proteins. Monoliths were prepared in microchannels by photopolymerization, and their properties were optimized by varying the composition and concentration of the monomers to improve flow
Shewit Kalayou et al.
Cell biology and toxicology, 30(6), 361-376 (2014-11-25)
The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable
Lena Schober et al.
Journal of laboratory automation, 20(2), 154-163 (2014-12-20)
Handling and dosing of cells comprise the most critical step in the microfabrication of cell-based assay systems for screening and toxicity testing. Therefore, the immediate drop-on-demand technology (I-DOT) was developed to provide a flexible noncontact liquid handling system enabling dispensing
Sergio Armenta et al.
Talanta, 130, 251-258 (2014-08-28)
An approach, based on ion mobility spectrometry (IMS) has been developed for the control of cocaine in air of the breathing zone of operators, in laboratory surfaces and in nasal mucus of employees to evaluate cocaine exposure in a forensic
Xuemin Qian et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(5), 343-361 (2015-03-22)
Chronic pulmonary inflammation has been consistently shown to increase the risk of lung cancer. Therefore, assessing the molecular links between the two diseases and identification of chemopreventive agents that inhibit inflammation-driven lung tumorigenesis is indispensable. Female A/J mice were treated
Kyoung-Jae Won et al.
Epigenetics & chromatin, 8, 13-13 (2015-04-17)
Histone variants play further important roles in DNA packaging and controlling gene expression. However, our understanding about their composition and their functions is limited. Integrating proteomic and genomic approaches, we performed a comprehensive analysis of the epigenetic landscapes containing the
M Vergara-Barberán et al.
Food chemistry, 169, 28-33 (2014-09-23)
The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic solvent, enzyme amount, pH
Yuan Li et al.
Molecules (Basel, Switzerland), 19(8), 11145-11159 (2014-07-31)
Cervical cancer is the second most common female carcinoma. Current therapies are often unsatisfactory, especially for advanced stage patients. The aim of this study was to explore the effects of tatariside G (TG) on apoptosis in human cervical cancer HeLa
Sumana Kladsomboon et al.
Analytica chimica acta, 757, 75-82 (2012-12-05)
In this work we have proposed a method for the detection of alcohol vapours, i.e. methanol, ethanol and isopropanol, based on the optical sensing response of magnesium 5,10,15,20-tetraphenyl porphyrin (MgTPP) thin films, as measured by optical spectrometry with the assistance
Syame Khater et al.
Journal of chromatography. A, 1373, 197-210 (2014-12-09)
In enantioselective supercritical fluid chromatography (SFC) with chiral stationary phases (CSP), the elution strength of carbon dioxide is usually modulated by the use of polar organic solvents, also called modifiers. Alcohols like methanol, ethanol and isopropanol are the most commonly
Frady G Adly et al.
Chirality, 26(11), 764-774 (2014-07-22)
A new series of dirhodium(II) tetracarboxylate was derived from N-1,2-naphthaloyl-(S)-amino acid ligands. In terms of enantioselectivity, Rh2 (S-1,2-NTTL)4 () derived from N-1,2-naphthaloyl-(S)-tert-leucine, was the best-performing catalyst among the new series in the enantioselective synthesis of cyclopropylphosphonate derivatives (up to >99%
Calum Johnston et al.
PloS one, 10(4), e0123702-e0123702 (2015-04-23)
CodY, a nutritional regulator highly conserved in low G+C Gram-positive bacteria, is essential in Streptococcus pneumoniae (the pneumococcus). A published codY mutant possessed suppressing mutations inactivating the fatC and amiC genes, respectively belonging to iron (Fat/Fec) and oligopeptide (Ami) ABC
Brian J Song et al.
Food chemistry, 173, 305-312 (2014-12-04)
Interactions between polyphenols and macromolecules may impact polyphenol stability and bioavailability from foods. The impact of milk on tea flavan-3-ol stability to thermal treatment was investigated. Single strength (36.2 protein per L), quarter strength (9.0 g protein per L) milk
Carlos M Laborde et al.
Proteome science, 12, 43-43 (2014-01-01)
Acute coronary syndrome is the major cause of death in developed countries. Despite its high prevalence, there is still a strong need for new biomarkers which permit faster and more accurate diagnostics and new therapeutic drugs. The basis for this
Federica Ianni et al.
Journal of chromatography. A, 1363, 101-108 (2014-04-15)
While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this
Martin Winter et al.
SLAS technology, 24(2), 209-221 (2018-08-04)
Label-free, mass spectrometric (MS) deciphering of enzymatic reactions by direct analysis of substrate-to-product conversion provides the next step toward more physiological relevant assays within drug discovery campaigns. Reduced risk of suffering from compound interference combined with diminished necessity for tailored
Annika Kasten et al.
PloS one, 9(9), e108055-e108055 (2014-09-23)
Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies for tissue engineering.
Evaluation of five antifungal agents used in remediation practices against six common indoor fungal species.
P Chakravarty et al.
Journal of occupational and environmental hygiene, 10(1), D11-D16 (2012-12-01)
Mieczysław Sajewicz et al.
Journal of chromatographic science, 52(4), 329-333 (2013-04-11)
Previous studies by the authors have used thin-layer chromatography to demonstrate the ability of chiral low molecular weight carboxylic acids to undergo spontaneous oscillatory chiral conversion in abiotic (aqueous and nonaqueous) solutions. General mechanisms of this conversion were proposed, taking
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