CN
Search Within
34863
应用筛选条件
关键词:'34863'
显示 1-30 共 809 条结果 关于 "34863" 范围 论文
Feifeng Jing et al.
International journal of oncology, 46(4), 1582-1588 (2015-01-28)
CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic
Gökçe Hatipoglu et al.
Cancer science, 106(2), 160-170 (2014-12-03)
Malignant gliomas can be counted to the most devastating tumors in humans. Novel therapies do not achieve significant prolonged survival rates. The cancer cells have an impact on the surrounding vital tissue and form tumor zones, which make up the
Jason Kindrachuk et al.
Antimicrobial agents and chemotherapy, 59(2), 1088-1099 (2014-12-10)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus, and infections with this virus can result in acute respiratory syndrome with renal failure. Globally, MERS-CoV has been responsible for 877 laboratory-confirmed infections, including 317 deaths, since September 2012.
Chuanzheng Sun et al.
International journal of molecular medicine, 35(3), 847-853 (2015-01-22)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health issue with a prevalence of 15-30% in Western populations and 6-25% in Asian populations. Certain studies have revealed the alteration of microRNA (miRNA or miR) profiles in NAFLD and
Kalpana Mandal et al.
Nature communications, 5, 5749-5749 (2014-12-11)
Cells sense and respond to their mechanical environment by exerting forces on their surroundings. The way forces are modulated by extra-cellular matrix (ECM) properties plays a key role in tissue homoeostasis. Using highly resolved micropatterns that constrain cells into the
Hyun Min Jung et al.
Journal of cellular biochemistry, 116(5), 836-843 (2014-12-19)
Head and neck cancer is one of the deadliest malignant diseases and chemotherapy is a common treatment option. Despite the development of chemotherapies for several decades, how these drugs affect the dynamics of gene regulation is still largely unknown. In
Timothy J Brazil et al.
Veterinary journal (London, England : 1997), 202(3), 536-542 (2014-09-23)
The aim of this study was to characterise constitutive apoptosis in equine peripheral blood neutrophils, including assessment of factors that potentially modulate neutrophil survival through alteration of the rate of constitutive apoptosis. Cells underwent spontaneous time-dependent constitutive apoptosis when aged
Pierre-Alexis Mouthuy et al.
Biotechnology letters, 37(5), 1107-1116 (2015-01-01)
To demonstrate that portable electrospinning devices can spin a wide range of polymers into submicron fibres and provide a mesh quality comparable to those produced with benchtop machines. We have designed a small, battery-operated electrospinning apparatus which enables control over
Eun Gyung Lee et al.
Journal of occupational and environmental hygiene, 10(2), 97-108 (2012-12-21)
This study introduces two semi-quantitative methods, Structured Subjective Assessment (SSA) and Control of Substances Hazardous to Health (COSHH) Essentials, in conjunction with two-dimensional Monte Carlo simulations for determining prior probabilities. Prior distribution using expert judgment was included for comparison. Practical
Paul R S Baker et al.
Journal of lipid research, 55(11), 2432-2442 (2014-09-17)
Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that contain many unique molecular species with
Robin P da Silva et al.
Biochimica et biophysica acta, 1841(11), 1639-1646 (2014-09-11)
Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study
João F Requicha et al.
Tissue engineering. Part A, 20(17-18), 2483-2492 (2014-03-01)
Human and canine periodontium are often affected by an inflammatory pathology called periodontitis, which is associated with severe damages across tissues, namely, in the periodontal ligament, cementum, and alveolar bone. However, the therapies used in the routine dental practice, often
Jin-Wook Lee et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(12), 2595-2603 (2014-05-28)
A dichlorobenzene-functionalized hole-transporting material (HTM) is developed for a CH3NH3PbI3-based perovskite solar cell. Notwithstanding the similarity of the frontier molecular orbital energy levels, optical properties, and hole mobility between the functionalized HTM [a polymer composed of 2'-butyloctyl-4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate (TT-BO), 3',4'-dichlorobenzyl-4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate (TT-DCB)
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
Linda Ahonen et al.
Journal of chromatography. A, 1364, 214-222 (2014-09-11)
We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of several oxysterols and vitamin D metabolites in mouse brain and cell line samples. An UHPLC-APPI-high resolution mass spectrometric (UHPLC-APPI-HRMS) method that
Miina Ollikainen et al.
Clinical epigenetics, 7, 39-39 (2015-04-14)
The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences
Leena M O Sahlström et al.
Environmental science & technology, 48(13), 7584-7592 (2014-06-14)
Tri-decabrominated diphenyl ethers and 21 other flame retardants were determined in matched serum samples from 24 Swedish mothers (Uppsala county) and their toddlers (11-15 months of age). The median concentrations of individual polybrominated diphenyl ethers (PBDEs) ranged from 0.036 to
David A Nagel et al.
Environmental toxicology and pharmacology, 38(3), 968-976 (2014-12-03)
Mixtures of pesticides in foodstuffs and the environment are ubiquitous in the developed world and although agents are usually exhaustively tested individually, the toxicological implications of pesticide mixtures are underreported. In this study, the effects of two fungicides, fenhexamid and
A A Dutov et al.
Biomeditsinskaia khimiia, 59(5), 514-518 (2014-02-01)
Proposed modified HPLC method for determination of valproic acid in biological fluids. Created solid-phase extraction of valproic and heptanoic acids (internal standard, IS) on the cartridges packed hyper cross-linked polystyrene which maintain some tens extractions without losses of efficiency. Carboxylic
María del Mar Ramírez Fernández et al.
Journal of analytical toxicology, 38(5), 280-288 (2014-05-03)
The aim of this work was to automate a sample preparation procedure extracting morphine, hydromorphone, oxymorphone, norcodeine, codeine, dihydrocodeine, oxycodone, 6-monoacetyl-morphine, hydrocodone, ethylmorphine, benzoylecgonine, cocaine, cocaethylene, tramadol, meperidine, pentazocine, fentanyl, norfentanyl, buprenorphine, norbuprenorphine, propoxyphene, methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine from urine samples.
Yuki Yoshioka et al.
Experimental cell research, 331(2), 408-415 (2014-12-30)
The effects of reactive oxygen species on cells have attracted considerable attention in relation to oxidative stress and related disorders. Superoxide (O2(-)) is the primary reactive oxygen species formed in animals as a byproduct or purposeful product of enzymes. We
Mona Freidin et al.
Experimental neurology, 263, 339-349 (2014-12-03)
X-linked Charcot-Marie-Tooth disease (CMT1X) is an inherited peripheral neuropathy caused by mutations in GJB1, the human gene for Connexin32 (Cx32). This present study uses Ilumina Ref8-v2 BeadArray to examine the expression profiles of injured and uninjured sciatic nerves at 5
Debra D Bloom et al.
Cytotherapy, 17(2), 140-151 (2014-12-03)
The T-cell suppressive property of bone marrow-derived mesenchymal stromal cells (MSCs) has been considered a major mode of action and basis for their utilization in a number of human clinical trials. However, there is no well-established reproducible assay to measure
Maribel Reyes et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 139-149 (2014-09-05)
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally administered, selective S1P1 receptor modulator that blocks the egress of lymphocytes from lymphoid organs and reduces the availability of circulating effector T/B-cells. 2. The mass balance, pharmacokinetics and metabolism of 40 mg (14)C-ponesimod were investigated in six
A W Jones et al.
Journal of analytical toxicology, 13(4), 199-203 (1989-07-01)
In the course of analyzing blood samples from drunk drivers, several low molecular weight volatiles were occasionally identified in addition to ethanol on the gas chromatograms. Among 21, 153 blood specimens analyzed during 1986, 77 contained ethanol as well as
Chunxiu Huang et al.
Biosensors & bioelectronics, 63, 478-482 (2014-08-19)
The electrogenerated chemiluminescence (ECL) behavior of the bioinspired peptide nanovesicles (PNVs) was reported for the first time. The PNVs modified glassy carbon electrodes have shown a stable and efficient cathodic ECL signal with K2S2O8 as coreactant in aqueous solution. The
V Matvejev et al.
The journal of physical chemistry. B, 116(48), 14071-14077 (2012-11-17)
Solvation in water requires minimizing the perturbations in its hydrogen bonded network. Hence solutes distort water molecular motions in a surrounding domain, forming a molecule-specific hydration shell. The properties of those hydration shells impact the structure and function of the
Cosima Damiana Calvano et al.
Analytical and bioanalytical chemistry, 407(3), 1015-1022 (2014-12-01)
Direct on-target plate processing of small (ca. 100 μg) fragments of paint samples for MALDI-MS identification of lipid- and protein-based binders is described. Fragments were fixed on a conventional stainless steel target plate by colloidal graphite followed by in situ fast
Michaella J Levy et al.
Analytical and bioanalytical chemistry, 406(26), 6559-6567 (2013-11-23)
The FDA has approved more than 100 protein and peptide drugs with hundreds more in the pipeline (Lanthier et al. in Nat Rev Drug Discov 7(9):733-737, 2008). Many of these originator biologic products are now coming off patent and are
Alexandra Toma et al.
Journal of chromatographic science, 52(10), 1302-1307 (2014-01-28)
The retention behavior for a series of new polyheterocyclic compounds containing azolic rings (1,3-thiazole, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole) has been investigated using reversed-phase thin-layer chromatography. Different approaches and computational methods were employed to evaluate their lipophilicity indices derived from chromatographic parameters.
1/27