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Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1. Rhabdomyolysis and the use of sodium bicarbonate and/or mannitol.
Rachel Thomas
Emergency medicine journal : EMJ, 27(4), 305-308 (2010-04-14)
Barak Cohen et al.
The American journal of emergency medicine, 31(12), 1703-1706 (2013-09-24)
Urine alkalinization is indicated for various medical conditions. Alkalinization is usually achieved by intravenous administration of alkali substances titrated by repeated urinalyses. Some situations such as mass casualty events might require urine alkalinization by the oral route. We evaluated the
Acid-base problems in diabetic ketoacidosis.
Kamel S Kamel et al.
The New England journal of medicine, 372(6), 546-554 (2015-02-05)
Veronica Estrella et al.
Cancer research, 73(5), 1524-1535 (2013-01-05)
The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H(+) diffuses from the
Prophylactic administration of bicarbonate to reduce the risk of postcardiac surgery acute kidney injury: end of the road?.
Charuhas V Thakar et al.
Critical care medicine, 41(7), 1802-1803 (2013-06-19)
Sodium bicarbonate use in the treatment of acute neonatal lactic acidosis: benefit or harm?
Patricia J Johnson
Neonatal network : NN, 30(3), 199-205 (2011-05-18)
Michael Haase et al.
PLoS medicine, 10(4), e1001426-e1001426 (2013-04-24)
Preliminary evidence suggests a nephroprotective effect of urinary alkalinization in patients at risk of acute kidney injury. In this study, we tested whether prophylactic bicarbonate-based infusion reduces the incidence of acute kidney injury and tubular damage in patients undergoing open
Sankar D Navaneethan et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 53(4), 617-627 (2008-11-26)
Optimal hydration measures to prevent contrast-induced nephropathy are controversial. We conducted a systematic review and meta-analysis using the MEDLINE database (1966 to January 2008), EMBASE (January 2008), and abstracts from conference proceedings. Adult patients undergoing contrast procedures. Randomized controlled trials
Lars R McNaughton et al.
Current sports medicine reports, 7(4), 230-236 (2008-07-09)
Athletes use many different strategies to enhance their performance, including clothing and footwear, training regimes, diets, and ergogenic aids. The use of ergogenic aids is believed to be widespread, with a variety of legal as well as illegal substances being
Novel approach for colonic insufflation via an untethered capsule (with video).
Keith L Obstein et al.
Gastrointestinal endoscopy, 77(3), 516-517 (2013-02-16)
Lactic acidosis.
Jeffrey A Kraut et al.
The New England journal of medicine, 371(24), 2309-2319 (2014-12-11)
Nilufar Mohebbi et al.
PloS one, 8(1), e55286-e55286 (2013-02-06)
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of
John H Boyd et al.
Current opinion in critical care, 14(4), 379-383 (2008-07-11)
Bicarbonate therapy for severe lactic acidosis remains a controversial therapy. The most recent 2008 Surviving Sepsis guidelines strongly recommend against the use of bicarbonate in patients with pH at least 7.15, while deferring judgment in more severe acidemia. We review
Bryan Saunders et al.
International journal of sports physiology and performance, 9(4), 627-632 (2013-10-25)
To determine whether gastrointestinal (GI) distress affects the ergogenicity of sodium bicarbonate and whether the degree of alkalemia or other metabolic responses is different between individuals who improve exercise capacity and those who do not. Twenty-one men completed 2 cycling-capacity
M M Liubishin et al.
Eksperimental'naia i klinicheskaia farmakologiia, 75(11), 31-34 (2013-01-18)
The development of delayed disorders caused by acute ethylene glycol poisoning has been studied in experiments on male rats. These disorders include chronic renal failure and secondary combined immunodeficiency status of the "circulus vitiosus" type. Urgent pharmacological correction was shown
Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute
Myra H Wyckoff et al.
Clinics in perinatology, 33(1), 141-151 (2006-03-15)
For adults and pediatric age patients, high-dose intravenous epinephrine was recommended if standard-dose epinephrine failed to achieve return of spontaneous circulation. More recent trials suggest that high-dose epinephrine is not beneficial and may result in increased harm. There are no
Case files of the University of California San Francisco Medical Toxicology Fellowship: acute chlorine gas inhalation and the utility of nebulized sodium bicarbonate.
John E Vajner et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 9(3), 259-265 (2013-05-31)
Should local anesthetic bladder cocktails include sodium bicarbonate? Yes.
C Lowell Parsons
The Journal of urology, 191(4), 895-896 (2014-01-22)
Sumita Agrawal et al.
The Journal of the Association of Physicians of India, 60, 55-56 (2013-02-15)
We report a rare case of a 38-year-old female who presented with sudden onset flaccid quadriplegia and respiratory arrest with no significant past clinical history. She was later found to have hypokalemia due to distal renal tubular acidosis and further
Yepeng Sun et al.
PloS one, 8(1), e53632-e53632 (2013-02-01)
Leymus chinensis (Trin.) Tzvel. is a high saline-alkaline tolerant forage grass genus of the tribe Gramineae family, which also plays an important role in protection of natural environment. To date, little is known about the saline-alkaline tolerance of L. chinensis
Hamit Ersoy et al.
Drug design, development and therapy, 7, 1-6 (2013-01-10)
The purpose of this study was to determine the effectiveness of a single early instillation of mitomycin C (MMC) after transurethral resection of bladder tumor (TURBT) together with urinary alkalinization in patients with low-risk non-muscle-invasive bladder cancer (NMIBC). Between February
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Somjot S Brar et al.
Clinical journal of the American Society of Nephrology : CJASN, 4(10), 1584-1592 (2009-08-29)
Infusion of sodium bicarbonate has been suggested as a preventative strategy but reports are conflicting on its efficacy. The aim of this study was to assess the effectiveness of hydration with sodium bicarbonate for the prevention of contrast-induced acute kidney
G Cave et al.
Clinical toxicology (Philadelphia, Pa.), 51(5), 394-397 (2013-05-25)
The use of intravenous lipid emulsion (ILE) as an antidote in non-local, anaesthetic drug toxicity has generated considerable interest. Flecainide is a lipophilic anti-arrhythmic with a significant cardiotoxic profile, with blockade of sodium and potassium channels causing arrhythmias and shock
Saravanan Gowrisankar et al.
ChemSusChem, 6(1), 85-91 (2013-01-03)
New benzoyl- and naphthoyl-substituted phosphines have been synthesized, which are stable to air and moisture. Testing these so-called phosphomide ligands in the presence of different ruthenium precursors, the hydrogenation of sodium bicarbonate (NaHCO(3)) to sodium formate (NaHCO(2)) proceeded with good
Judy L Aschner et al.
Pediatrics, 122(4), 831-835 (2008-10-03)
Common clinical practices often are unsupported by experimental evidence. One example is the administration of sodium bicarbonate to neonates. Despite a long history of widespread use, objective evidence that administration of sodium bicarbonate improves outcomes for patients in cardiopulmonary arrest
James J Barber et al.
Journal of strength and conditioning research, 27(1), 252-258 (2012-12-21)
Creatine and sodium bicarbonate supplementation independently increase exercise performance, but it remains unclear whether combining these 2 supplements is more beneficial on exercise performance. The purpose of this study was to evaluate the impact of combining creatine monohydrate and sodium
Jae-Sik Jang et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(9), 2255-2265 (2012-09-15)
Sodium bicarbonate has been postulated to prevent contrast-induced acute kidney injury (CI-AKI) by various mechanisms, although the reports are conflicting. We searched MEDLINE, EMBASE, and the Cochrane databases for randomized controlled trials that compared a sodium chloride with a sodium
Melissa J Parker et al.
Critical care medicine, 41(9), 2188-2195 (2013-06-14)
To evaluate the preferences and self-reported practices of pediatric acute care physicians with respect to sodium bicarbonate administration to infants and children in shock or cardiac arrest. National survey study utilizing a self-administered questionnaire. Thirteen Canadian pediatric tertiary care centers.
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