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Jing Wang et al.
Chinese journal of natural medicines, 14(11), 865-870 (2016-12-05)
Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little
Qi Song et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(1), 135-142 (2005-11-22)
Bioanalytical methods using liquid/liquid extraction (LLE) and liquid chromatography with electrospray tandem mass spectrometry (LC-MS/MS) are widely used. The organic extracts need to be evaporated and reconstituted, hampering further improvement of throughput and automation. In this study, we demonstrated a
S K Jin et al.
Journal of clinical pharmacy and therapeutics, 34(4), 437-446 (2009-07-09)
CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim
Lin-Hu Ye et al.
Biomedical chromatography : BMC, 32(8), e4250-e4250 (2018-03-27)
Danhong Injection (DHI) as a Chinese patent medicine is mainly used to treat ischemic encephalopathy and coronary heart disease in combination with other chemotherapy. However, the information on DHI's potential drug interactions is limited. The goal of this work was
Maryam Noubarani et al.
Biopharmaceutics & drug disposition, 33(6), 324-331 (2012-08-15)
Omeprazole is metabolized in the liver mainly by the polymorphic CYP2C19 enzyme. Considerable ethnic differences have been reported in the pharmacokinetics of omeprazole. The present study was conducted to evaluate the pharmacokinetic parameters of omeprazole after a single oral administration
Eileen B Lawson et al.
European journal of clinical pharmacology, 68(4), 407-413 (2011-10-20)
To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. Data were
Takenori Niioka et al.
European journal of clinical pharmacology, 63(11), 1031-1038 (2007-08-19)
The purpose of this study was to identify the common time point to achieve hydroxylation index (HI: omeprazole plasma concentration/5-hydroxyomeprazole plasma concentration) reflecting AUCOPZ/AUC5OH-OPZ after intravenous (IV) and oral (PO) administration. Twenty young and 28 elderly healthy subjects, including different
Daphne Williams et al.
British journal of clinical pharmacology, 83(2), 370-380 (2016-11-04)
This open-label study investigated the effect of belatacept on cytokine levels and on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam, as CYP probe substrates after oral administration of the Inje cocktail in healthy volunteers. Twenty-two evaluable subjects received
Julia Dinger et al.
Toxicology letters, 241, 82-94 (2015-11-26)
New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl tryptamines (DMTs), diallyl tryptamines (DALTs), and diisopropyl tryptamines (DiPTs) using
Claudia Suenderhauf et al.
British journal of clinical pharmacology, 86(2), 352-361 (2019-10-29)
We compared the phenotyping metrics of a combination capsule formulation to its individual components of the newly composed Basel phenotyping cocktail. Moreover, we investigated a reduced sampling regimen for clinical applications. We performed in vitro experiments and a crossover pharmacokinetic
Diana Busch et al.
Journal of pharmaceutical and biomedical analysis, 155, 194-201 (2018-04-13)
Many orally administered drugs are subject to first-pass metabolism by cytochrome P450 (CYP) enzymes and uridine 5'-diphospho-glucuronosyltransferases (UGT). While their hepatic activity is well characterized, respective information about the intestine are very scare due to limited availability of tissue, very
Jiu-Hui Wang et al.
Clinical and experimental pharmacology & physiology, 34(5-6), 421-424 (2007-04-19)
1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles
Mihwa Kwon et al.
Pharmaceutics, 12(10) (2020-10-04)
This study was designed to develop and validate a 10 probe drug cocktail named "Dual Cocktail", composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11
Adrian Derungs et al.
Clinical pharmacokinetics, 55(1), 79-91 (2015-07-01)
Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The
Qingxiang Zhong et al.
The Journal of pharmacy and pharmacology, 69(10), 1398-1408 (2017-06-28)
This study aims to investigate potential herb-drug interactions (HDI) of Epimedium koreanum Nakai. Human liver microsomes (HLMs) were used to determine the enzyme kinetics of the major human cytochrome P450s (CYPs). Inducible potential of E. koreanum on CYP1A2, 2B6, 2C19 and
Carlos Hoyo-Vadillo et al.
Proceedings of the Western Pharmacology Society, 48, 108-109 (2006-01-19)
Proton pump inhibitors (PPIs) have been used recently for gastrointestinal esophageal reflux disease (GERD) in children older than one year with good results. However, the pharmacokinetics of PPIs have not been studied in children less than two years old. The
S Rosenborg et al.
Clinical pharmacology and therapeutics, 88(3), 343-346 (2010-07-30)
Noscapine and glucosamine reportedly interact with warfarin. We investigated the effects of these drugs on various cytochrome P450 (CYP) activity markers. Twelve healthy subjects were phenotyped at baseline and during separate treatments with noscapine and glucosamine. Whereas glucosamine had no
Julia Dinger et al.
Archives of toxicology, 90(2), 305-318 (2014-11-25)
In vitro cytochrome P450 (CYP) inhibition assays are common approaches for testing the inhibition potential of drugs for predicting potential interactions. In contrast to marketed medicaments, drugs of abuse, particularly the so-called novel psychoactive substances, were not tested before distribution
Hui Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(12), 1317-1325 (2017-10-08)
Variable drug responses depend on individual variation in the activity of drug-metabolizing enzymes, including cytochrome P450 enzymes (CYP). As the most common chronic liver disease in children and adults, nonalcoholic steatohepatitis (NASH) has been identified as a source of significant
Yue Li et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(2), 152-160 (2018-01-24)
Tanshinone I (TSI) is a lipophilic diterpene in Salvia miltiorrhiza with versatile pharmacological activities. However, metabolic pathway of TSI in human is unknown. In this study, we determined major metabolites of TSI using a preparation of human liver microsomes (HLMs)
Kyung-Suk Oh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 895-896, 56-64 (2012-04-10)
A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method with electrospray ionization was developed for the simultaneous quantitation of five probe drugs and their metabolites in human plasma for assessing the in vivo activities of cytochrome P450 (CYP). CYP isoform specific
Tao Hu et al.
Chemico-biological interactions, 230, 1-8 (2015-02-18)
This study aimed to investigate the effects of five tanshinones, the lipophilic components from Danshen (Salvia miltiorrhiza), on CYP2C19 activity in pooled human liver microsomes (HLMs). The effects of tanshinones on CYP2C19 activity were compared by enzyme inhibition study using
Hideo Shiohira et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2465-2470 (2011-07-26)
Studies investigating the relationship between CYP2C19 genotype and the stereoselective metabolism of omeprazole have not been reported. In the present study, we developed a simple and sensitive analytical method based on column switching reversed phase high-performance liquid chromatography (HPLC) with
Ersin Gumus et al.
European journal of clinical pharmacology, 68(5), 629-636 (2011-11-15)
Lansoprazole, a cytochrome P450 2C19 (CYP2C19) substrate, has been widely used in children to manage acid-related diseases. CYP2C19 exhibits marked genetic polymorphisms, and distribution of these polymorphisms varies among different ethnic groups. There is limited data regarding the use of
Huan Wang et al.
Environmental toxicology and pharmacology, 80, 103487-103487 (2020-09-06)
In the new drugs, greater than 90 % of active pharmaceutical ingredients (APIs) or marketed drugs have poor solubility and bioavailability, which restrict the development of pharmaceutical preparations. The use of crystalline molecular complexes (CMCs) involving API and biocompatible precursors
Amelia Nathania Dong et al.
Current molecular pharmacology, 13(3), 233-244 (2019-11-13)
There is a large inter-individual variation in cytochrome P450 2C19 (CYP2C19) activity. The variability can be caused by the genetic polymorphism of CYP2C19 gene. This study aimed to investigate the molecular and kinetics basis for activity changes in three alleles
Jeanette Olsson et al.
Journal of chromatography. A, 1129(2), 291-295 (2006-07-21)
This study demonstrates the development and validation of a non-aqueous capillary electrophoresis (NACE) method for enantiomeric determination of omeprazole and its metabolite 5-hydroxyomeprazole. Heptakis-(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (HDMS-beta-CD) was chosen as the chiral selector in an ammonium acetate buffer acidified with formic acid
Ying Peng et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(11), 961-977 (2015-05-27)
1. A comprehensive method for the simultaneous characterization of xenobiotic compound inhibition of nine major CYP enzymes in human liver microsomes was established by using 16 CYP-catalyzed reactions of 14 probe substrates with three cocktail incubation sets and a single LC/MS/MS
Tomás Pérez-Ruiz et al.
Journal of pharmaceutical and biomedical analysis, 42(1), 100-106 (2005-11-11)
A sensitive method for the determination of omeprazole and its metabolites has been developed. It involves an automated solid phase extraction (SPE) procedure and capillary electrophoresis with UV detection. Omeprazole, hydroxyomeprazole and omeprazole sulfone could be separated by micellar electrokinetic
Yannick Parmentier et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(1), 22-35 (2018-01-04)
1. We have applied the concept of using MBIs to produce CYP-Silensomes to quantify the contribution of the major CYPs to drug metabolism (fmCYP). 2. The target CYPs were extensively and selectivity inhibited by the selected MBIs, while non-target CYPs were inhibited
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