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Takenori Niioka et al.
European journal of clinical pharmacology, 63(11), 1031-1038 (2007-08-19)
The purpose of this study was to identify the common time point to achieve hydroxylation index (HI: omeprazole plasma concentration/5-hydroxyomeprazole plasma concentration) reflecting AUCOPZ/AUC5OH-OPZ after intravenous (IV) and oral (PO) administration. Twenty young and 28 elderly healthy subjects, including different
Eileen B Lawson et al.
European journal of clinical pharmacology, 68(4), 407-413 (2011-10-20)
To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. Data were
Maryam Noubarani et al.
Biopharmaceutics & drug disposition, 33(6), 324-331 (2012-08-15)
Omeprazole is metabolized in the liver mainly by the polymorphic CYP2C19 enzyme. Considerable ethnic differences have been reported in the pharmacokinetics of omeprazole. The present study was conducted to evaluate the pharmacokinetic parameters of omeprazole after a single oral administration
S K Jin et al.
Journal of clinical pharmacy and therapeutics, 34(4), 437-446 (2009-07-09)
CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim
Daphne Williams et al.
British journal of clinical pharmacology, 83(2), 370-380 (2016-11-04)
This open-label study investigated the effect of belatacept on cytokine levels and on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam, as CYP probe substrates after oral administration of the Inje cocktail in healthy volunteers. Twenty-two evaluable subjects received
Qi Song et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(1), 135-142 (2005-11-22)
Bioanalytical methods using liquid/liquid extraction (LLE) and liquid chromatography with electrospray tandem mass spectrometry (LC-MS/MS) are widely used. The organic extracts need to be evaporated and reconstituted, hampering further improvement of throughput and automation. In this study, we demonstrated a
Lin-Hu Ye et al.
Biomedical chromatography : BMC, 32(8), e4250-e4250 (2018-03-27)
Danhong Injection (DHI) as a Chinese patent medicine is mainly used to treat ischemic encephalopathy and coronary heart disease in combination with other chemotherapy. However, the information on DHI's potential drug interactions is limited. The goal of this work was
Jing Wang et al.
Chinese journal of natural medicines, 14(11), 865-870 (2016-12-05)
Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little
Julia Dinger et al.
Toxicology letters, 241, 82-94 (2015-11-26)
New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl tryptamines (DMTs), diallyl tryptamines (DALTs), and diisopropyl tryptamines (DiPTs) using
Jiu-Hui Wang et al.
Clinical and experimental pharmacology & physiology, 34(5-6), 421-424 (2007-04-19)
1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles
Claudia Suenderhauf et al.
British journal of clinical pharmacology, 86(2), 352-361 (2019-10-29)
We compared the phenotyping metrics of a combination capsule formulation to its individual components of the newly composed Basel phenotyping cocktail. Moreover, we investigated a reduced sampling regimen for clinical applications. We performed in vitro experiments and a crossover pharmacokinetic
Mihwa Kwon et al.
Pharmaceutics, 12(10) (2020-10-04)
This study was designed to develop and validate a 10 probe drug cocktail named "Dual Cocktail", composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11
Adrian Derungs et al.
Clinical pharmacokinetics, 55(1), 79-91 (2015-07-01)
Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The
Diana Busch et al.
Journal of pharmaceutical and biomedical analysis, 155, 194-201 (2018-04-13)
Many orally administered drugs are subject to first-pass metabolism by cytochrome P450 (CYP) enzymes and uridine 5'-diphospho-glucuronosyltransferases (UGT). While their hepatic activity is well characterized, respective information about the intestine are very scare due to limited availability of tissue, very
Qingxiang Zhong et al.
The Journal of pharmacy and pharmacology, 69(10), 1398-1408 (2017-06-28)
This study aims to investigate potential herb-drug interactions (HDI) of Epimedium koreanum Nakai. Human liver microsomes (HLMs) were used to determine the enzyme kinetics of the major human cytochrome P450s (CYPs). Inducible potential of E. koreanum on CYP1A2, 2B6, 2C19 and
Kyung-Suk Oh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 895-896, 56-64 (2012-04-10)
A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method with electrospray ionization was developed for the simultaneous quantitation of five probe drugs and their metabolites in human plasma for assessing the in vivo activities of cytochrome P450 (CYP). CYP isoform specific
Yue Li et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(2), 152-160 (2018-01-24)
Tanshinone I (TSI) is a lipophilic diterpene in Salvia miltiorrhiza with versatile pharmacological activities. However, metabolic pathway of TSI in human is unknown. In this study, we determined major metabolites of TSI using a preparation of human liver microsomes (HLMs)
Hui Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(12), 1317-1325 (2017-10-08)
Variable drug responses depend on individual variation in the activity of drug-metabolizing enzymes, including cytochrome P450 enzymes (CYP). As the most common chronic liver disease in children and adults, nonalcoholic steatohepatitis (NASH) has been identified as a source of significant
Julia Dinger et al.
Archives of toxicology, 90(2), 305-318 (2014-11-25)
In vitro cytochrome P450 (CYP) inhibition assays are common approaches for testing the inhibition potential of drugs for predicting potential interactions. In contrast to marketed medicaments, drugs of abuse, particularly the so-called novel psychoactive substances, were not tested before distribution
S Rosenborg et al.
Clinical pharmacology and therapeutics, 88(3), 343-346 (2010-07-30)
Noscapine and glucosamine reportedly interact with warfarin. We investigated the effects of these drugs on various cytochrome P450 (CYP) activity markers. Twelve healthy subjects were phenotyped at baseline and during separate treatments with noscapine and glucosamine. Whereas glucosamine had no
Carlos Hoyo-Vadillo et al.
Proceedings of the Western Pharmacology Society, 48, 108-109 (2006-01-19)
Proton pump inhibitors (PPIs) have been used recently for gastrointestinal esophageal reflux disease (GERD) in children older than one year with good results. However, the pharmacokinetics of PPIs have not been studied in children less than two years old. The
Tomás Pérez-Ruiz et al.
Journal of pharmaceutical and biomedical analysis, 42(1), 100-106 (2005-11-11)
A sensitive method for the determination of omeprazole and its metabolites has been developed. It involves an automated solid phase extraction (SPE) procedure and capillary electrophoresis with UV detection. Omeprazole, hydroxyomeprazole and omeprazole sulfone could be separated by micellar electrokinetic
Amelia Nathania Dong et al.
Current molecular pharmacology, 13(3), 233-244 (2019-11-13)
There is a large inter-individual variation in cytochrome P450 2C19 (CYP2C19) activity. The variability can be caused by the genetic polymorphism of CYP2C19 gene. This study aimed to investigate the molecular and kinetics basis for activity changes in three alleles
Yukio Ishizawa et al.
Clinical pharmacokinetics, 44(11), 1179-1189 (2005-10-20)
The metabolic activity of cytochrome P450 (CYP) 2C19 is genetically determined, and the pharmacokinetics of omeprazole, a substrate for CYP2C19, are dependent on the CYP2C19 genotype. However, a discrepancy between the CYP2C19 genotype and omeprazole pharmacokinetics was reported in patients
Shane K Eagles et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1140, 122013-122013 (2020-02-13)
Measuring in vivo changes in the drug metabolizing activity of cytochrome P450 (CYP) enzymes is critical to understanding and assessing drug-drug, drug-diet and drug-disease interactions. The sensitivity and specificity of ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) makes it an
Joanne Roberts et al.
Rapid communications in mass spectrometry : RCM, 32(12), 929-941 (2018-03-24)
Omeprazole is used to treat gastric disorders and is one of the most commonly consumed drugs in the western world. It forms several metabolites but is mostly excreted unchanged and as 5-hydroxyomeprazole. Since omeprazole is widely prescribed, its excretion from
Tao Hu et al.
Chemico-biological interactions, 230, 1-8 (2015-02-18)
This study aimed to investigate the effects of five tanshinones, the lipophilic components from Danshen (Salvia miltiorrhiza), on CYP2C19 activity in pooled human liver microsomes (HLMs). The effects of tanshinones on CYP2C19 activity were compared by enzyme inhibition study using
Yu-Xin Wang et al.
Chinese journal of natural medicines, 17(7), 517-524 (2019-09-14)
We investigated the potential hepatoprotective effect of Radix Bupleuri (RB) by inducing acute liver injury (ALI) in an animal model using acetaminophen (APAP) after pretreatment with RB aqueous extract for three consecutive days. Compared to those of the APAP group
Ying Peng et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(11), 961-977 (2015-05-27)
1. A comprehensive method for the simultaneous characterization of xenobiotic compound inhibition of nine major CYP enzymes in human liver microsomes was established by using 16 CYP-catalyzed reactions of 14 probe substrates with three cocktail incubation sets and a single LC/MS/MS
Jeanette Olsson et al.
Journal of chromatography. A, 1129(2), 291-295 (2006-07-21)
This study demonstrates the development and validation of a non-aqueous capillary electrophoresis (NACE) method for enantiomeric determination of omeprazole and its metabolite 5-hydroxyomeprazole. Heptakis-(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (HDMS-beta-CD) was chosen as the chiral selector in an ammonium acetate buffer acidified with formic acid
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