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Georg Bauer et al.
Carcinogenesis, 35(7), 1582-1591 (2014-03-26)
Malignant transformation of gastric epithelial cells by chronic Helicobacter pylori infection is caused by several mechanisms including attraction of reactive oxygen species (ROS)-producing neutrophils and cytotoxin-associated antigen A-mediated dysplastic alterations. Here we show that H.pylori protects transformed cells from ROS-mediated
Emma C Hansson et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 46(4), 699-705 (2014-02-01)
Ticagrelor reduces thrombotic events compared with clopidogrel in patients with acute coronary syndrome, but may also increase bleeding complications. Coronary artery bypass grafting (CABG)-related bleeding complications have not previously been compared in clopidogrel and ticagrelor-treated patients outside the controlled environment
H De Boeck et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(8), 1567-1572 (2015-05-02)
Methicillin-resistant Staphylococcus aureus (MRSA) is a global health concern, but there are few data from Central Africa. The objective of our study was to characterise S. aureus colonisation isolates from healthcare-exposed professionals in the Democratic Republic of the Congo (DRC).
Ting He et al.
Molecular and cellular endocrinology, 402, 13-20 (2014-12-30)
Resveratrol (RSV) is reported to have renoprotective activity against diabetic nephropathy, while the mechanisms underlying its function have not been fully elucidated. In this study, we investigate the effect and related mechanism of RSV against high glucose-induced epithelial to mesenchymal
Rebeca Penalva et al.
Journal of agricultural and food chemistry, 63(23), 5603-5611 (2015-06-02)
Resveratrol offers pleiotropic health benefits including a reported ability to inhibit lipopolysaccharide (LPS)-induced cytokine production. The aim of this work was to prepare, characterize, and evaluate a resveratrol nanoparticulate formulation based on zein. For this purpose, the oral bioavailability of
Eman F Ahmed et al.
Surgical infections, 15(4), 404-411 (2014-05-13)
Staphylococcus aureus (S. aureus) is isolated frequently from surgical site infections and other soft tissue infections. There are limited data examining the prevalence of methicillin resistant S. aureus (MRSA) among Egyptian patients after surgery. The current study determined the prevalence
Ivana R Sequeira et al.
Clinical and experimental pharmacology & physiology, 41(2), 107-117 (2013-09-17)
The effects of inflammatory changes on the absorption of different-sized probes and their permeability ratios are poorly understood. The aim of the present study was to determine the effects of a pharmacological agent on the permeability of the gut mucosa
Total inhibition of (1)O2-induced oxidative damage to guanine bases of DNA/RNA by turmeric extracts.
Prakash C Joshi et al.
Biochemical and biophysical research communications, 452(3), 515-519 (2014-09-03)
The guanine base of nucleic acids is known to be very reactive towards degradation by (1)O2-induced oxidative stress. Oxidative reactions of DNA are linked to many human diseases including cancer. Among the various forms of reactive O2 species (OH, (1)O2
John J Gildea et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(11), R1447-R1459 (2015-10-09)
The electrogenic sodium bicarbonate cotransporter (NBCe2) is encoded by SLC4A5, variants of which have been associated with salt sensitivity of blood pressure, which affects 25% of the adult population. NBCe2 is thought to mediate sodium bicarbonate cotransport primarily in the
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1. Rhabdomyolysis and the use of sodium bicarbonate and/or mannitol.
Rachel Thomas
Emergency medicine journal : EMJ, 27(4), 305-308 (2010-04-14)
Marta Zwiewka et al.
Molecular plant, 8(8), 1175-1187 (2015-03-22)
The sessile life style of plants creates the need to deal with an often adverse environment, in which water availability can change on a daily basis, challenging the cellular physiology and integrity. Changes in osmotic conditions disrupt the equilibrium of
Emma Goksör et al.
Pediatric pulmonology, 50(8), 789-797 (2014-08-20)
Severe wheezing in early life is associated with an increased risk of asthma during childhood and adolescence. The aim of the present follow-up was to investigate the asthma prevalence and risk factors for asthma in adulthood. We have prospectively studied
Abel Wakai et al.
The Cochrane database of systematic reviews, 8(8), CD001049-CD001049 (2013-08-07)
Mannitol is sometimes effective in reversing acute brain swelling, but its effectiveness in the ongoing management of severe head injury remains unclear. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it
Christopher J Burns et al.
Bioorganic & medicinal chemistry letters, 19(20), 5887-5892 (2009-09-19)
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported.
Daniele Lettieri Barbato et al.
Scientific reports, 5, 13091-13091 (2015-08-12)
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione
Nicole Willems et al.
Arthritis research & therapy, 17, 137-137 (2015-05-28)
Strategies for biological repair and regeneration of the intervertebral disc (IVD) by cell and tissue engineering are promising, but few have made it into a clinical setting. Recombinant human bone morphogenetic protein 7 (rhBMP-7) has been shown to stimulate matrix
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
Fengzhen Wang et al.
Journal of liposome research, 24(3), 171-181 (2014-03-13)
The purpose of the present study was to optimize methazolamide (MTZ)-loaded solid lipid nanoparticles (SLNs) which were used as topical eye drops by evaluating the relationship between design factors and experimental data. A three factor, three-level Box-Behnken design (BBD) was
Alain Weber et al.
Journal of experimental botany, 66(11), 3229-3241 (2015-04-16)
Growth in plants results from the interaction between genetic and signalling networks and the mechanical properties of cells and tissues. There has been a recent resurgence in research directed at understanding the mechanical aspects of growth, and their feedback on
M M Santana et al.
Mikrobiologiia, 81(6), 720-725 (2013-04-25)
Desulfovibrio vulgaris Hildenborough genome presents a phosphotransferase system putatively involved in the transport of carbohydrates. However, utilization of sugars by this sulfate-reducing bacterium has never been reported. Herein, we have observed proliferation of D. vulgaris Hildenborough with some carbohydrates, in
Marcus L Ware et al.
Neurosurgery, 57(4), 727-736 (2005-10-22)
Mannitol is the standard of care for patients with increased intracranial pressure (ICP), but multiple administrations of mannitol risk renal toxicity and fluid accumulation in the brain parenchyma with consequent worsening of cerebral edema. This preliminary study assessed the safety
Jenny K Gustafsson et al.
Pflugers Archiv : European journal of physiology, 467(7), 1403-1415 (2014-08-21)
The colonic mucosa protects itself from the luminal content by secreting mucus that keeps the bacteria at a distance from the epithelium. For this barrier to be effective, the mucus has to be constantly replenished which involves exocytosis and expansion
Yasmin Schmid et al.
The Journal of pharmacology and experimental therapeutics, 353(1), 102-111 (2015-02-07)
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases
Celeste Porsbjerg et al.
The clinical respiratory journal, 3(4), 189-197 (2010-03-20)
Asthma is a disease associated with inflammation, airway hyperresponsiveness (AHR) and airflow limitation. Clinical diagnosis and management of asthma often relies on assessment of lung function and symptom control, but these factors do not always correlate well with underlying inflammation.
Julie Czupryna et al.
PloS one, 6(5), e20073-e20073 (2011-05-24)
Over the past decade, firefly Luciferase (fLuc) has been used in a wide range of biological assays, providing insight into gene regulation, protein-protein interactions, cell proliferation, and cell migration. However, it has also been well established that fLuc activity can
Przemysław Koźmiński et al.
Nuclear medicine and biology, 42(1), 28-37 (2014-09-15)
Ghrelin is an endogenous hormone present in blood. It is released from the oxyntic cells (X/A-like cells) of the stomach and fundus and can exist in two forms: as an acylated and des-acylated ghrelin. Ghrelin is an endogenous ligand of
Clifford C Ugwu et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 46(3), 885-892 (2015-09-29)
This study was conducted to determine the species distribution, antimicrobial resistance pheno- and genotypes and virulence traits of mannitol-positive methicillin-resistant staphylococci (MRS) isolated from pigs in Nsukka agricultural zone, Nigeria. Twenty mannitol-positive methicillin-resistant coagulase-negative staphylococcal (MRCoNS) strains harboring the mecA
Sundeep Chaurasia et al.
Carbohydrate polymers, 130, 9-17 (2015-06-17)
Soluthin MD(®), a unique phosphatidylcholine-maltodextrin based hydrophilic lipopolysaccharide, which exhibits superior biocompatibility and bioavailability enhancer properties for poorly water soluble drug(s). Curcumin (CUR) is a potential natural anticancer drug with low bioavailability due to poor aqueous solubility. The study aims
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