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Douglas L Huseby et al.
Journal of bacteriology, 195(12), 2864-2879 (2013-04-16)
Microcompartments are loose protein cages that encapsulate enzymes for particular bacterial metabolic pathways. These structures are thought to retain and perhaps concentrate pools of small, uncharged intermediates that would otherwise diffuse from the cell. In Salmonella enterica, a microcompartment encloses
Richard J Albertini
Critical reviews in toxicology, 43(8), 671-706 (2013-08-30)
Vinyl acetate monomer (VAM) is a site-of-contact carcinogen in rodents. It is also DNA reactive and mutagenic, but only after its carboxylesterase mediated conversion to acetaldehyde (AA), a metabolic reaction that also produces acetic acid and protons. As VAM's mutagenic
Susumu Higuchi et al.
Annals of the New York Academy of Sciences, 1025, 472-480 (2004-11-16)
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase-2 (ALDH2) play central roles in the metabolism of ethanol and its metabolite, acetaldehyde, in the liver. In ADH2, one nucleotide replacement causes either a super-active beta 2 subunit encoded by the ADH2*2 allele or
Allison C Hoffman et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 15(3), 622-632 (2012-09-20)
This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their effects on midbrain dopamine (DA) levels, drug discrimination and substitution for known drugs of
Kadri Aller et al.
Microbiology (Reading, England), 161(Pt 5), 1073-1080 (2015-03-07)
Lactococcus lactis is an important lactic acid starter for food production as well as a cell factory for production of food grade additives, among which natural flavour production is one of the main interests of food producers. Flavour production is
Rui Guo et al.
Journal of hepatology, 62(3), 647-656 (2014-12-03)
Mitochondrial aldehyde dehydrogenase (ALDH2) plays a critical role in the detoxification of the ethanol metabolite acetaldehyde. This study was designed to examine the impact of global ALDH2 overexpression on alcohol-induced hepatic steatosis. Wild type Friend virus B (FVB) and ALDH2
Toshiharu Oba et al.
Current pharmaceutical design, 11(6), 791-780 (2005-03-22)
Acute intoxication due to alcohol consumption has been known to elicit reversible skeletal and cardiac muscle dysfunction, or "alcoholic myopathy and cardiomyopathy". Sometimes, irreversible muscle damage can be induced after heavy alcohol drinking. Many researchers have proposed that acetaldehyde, the
Mengyao Zhao et al.
Food chemistry, 141(3), 3260-3267 (2013-07-23)
Understanding the degradation of anthocyanins (Acys) during microwave treatment is required for the application of this novel technology to fruit and vegetable processing. The pH 3.5 buffer solutions containing 50mg/l malvidin-3-glucoside (Mv-3-glu) and malvidin-3,5-diglucoside (Mv-3,5-diglu), respectively, were treated with microwaves
Fan Fan et al.
Acta pharmacologica Sinica, 35(8), 1015-1022 (2014-07-08)
To investigate the roles of acetaldehyde dehydrogenase 2 (ALDH2), the key enzyme of ethanol metabolism, in chronic low to moderate alcohol consumption-induced heart protective effects in mice. Twenty-one male wild-type (WT) or ALDH2-knockout (KO) mice were used in this study.
O V Tyulina et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 37(2), 179-186 (2002-03-26)
In vitro experiments were performed to determine if ethanol was metabolized by human erythrocytes and to investigate if ethanol or its metabolites, acetaldehyde and fatty acid ethyl esters, affected erythrocyte morphology and stability. No detectable metabolism of ethanol was found
Neil R McGregor
Alcohol (Fayetteville, N.Y.), 41(7), 469-478 (2007-11-06)
Recent introduction of several commercial Kudzu root (Pueraria lobata) containing hangover remedies has occurred in western countries. The available data is reviewed to assess if there are any potential concerns in relationship to the development of neoplasm if these products
E M Goldberg et al.
Journal of chromatography, 226(2), 291-299 (1981-12-11)
Volatile organic substances present in blood plasma and cerebrospinal fluids of certain control groups of human subjects and cirrhotic patients some of whom were suffering from hepatic encephalopathy were quantitatively analysed and identified. A rapid, reproducible, direct injection capillary column
L Feller et al.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 68(4), 176-180 (2013-08-27)
Alcohol is a risk factor for oral squamous cell carcinoma. It enhances the permeability of the oral epithelium, acts as a solvent for tobacco carcinogens, induces basal-cell proliferation, and generates free radicals and acetaldehyde, which have the capacity to cause
Keitaro Matsuo et al.
Carcinogenesis, 34(7), 1510-1515 (2013-03-05)
The impact of alcohol on the risk of stomach cancer is controversial. Although aldehyde dehydrogenase 2 (ALDH2) Glu504Lys (rs671) polymorphism has a strong effect on acetaldehyde metabolism, little is known about its impact on stomach cancer risk when combined with
Janna Cropotova et al.
Food chemistry, 194, 175-183 (2015-10-17)
The aim of the present study was to estimate the quality deterioration of apple fillings during storage. Moreover, a potentiality of novel time-saving and non-invasive method based on fluorescence microscopy for prompt ascertainment of non-enzymatic browning initiation in fruit fillings
Wen-Xuan Wang et al.
Applied microbiology and biotechnology, 99(18), 7651-7662 (2015-05-12)
The basis of chemical crosstalk in plants and associated endophytes lies in certain so-called communication molecules that are responsible for plant-microbe and microbe-microbe interactions. Consequently, elucidating the factors that affect the nature, distribution, and amount of these molecules and how
Hugh D Lothrop et al.
Journal of medical entomology, 49(6), 1466-1472 (2012-12-29)
Laboratory and field research was conducted to determine if Culex tarsalis Coquillett expectorated West Nile virus (WNV) during sugar feeding and if a lure or bait station could be developed to exploit this behavior for WNV surveillance. Experimentally infected Cx.
Rubén del Barrio-Galán et al.
Journal of the science of food and agriculture, 95(10), 2132-2144 (2014-09-27)
The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to subsequent aging on lees with or without oak wood chips as well
Venkataramanan Subramanian et al.
Journal of proteome research, 13(12), 5431-5451 (2014-10-22)
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic
Jacob A Theruvathu et al.
Nucleic acids research, 33(11), 3513-3520 (2005-06-24)
Alcoholic beverage consumption is associated with an increased risk of upper gastrointestinal cancer. Acetaldehyde (AA), the first metabolite of ethanol, is a suspected human carcinogen, but the molecular mechanisms underlying AA carcinogenicity are unclear. In this work, we tested the
Miriam Melis et al.
Alcohol (Fayetteville, N.Y.), 43(7), 531-539 (2009-11-17)
There has been a great deal of activity in recent years in the study of the direct effects of ethanol on the dopamine reward system originating in the ventral tegmental area (VTA). In addition, recent evidence suggests that acetaldehyde formed
Gerald A Deehan et al.
Current topics in behavioral neurosciences, 13, 163-184 (2012-02-22)
Alcohol abuse and alcoholism represent substantial problems that affect a large portion of individuals throughout the world. Extensive research continues to be conducted in an effort to identify the biological basis of the reinforcing properties of alcohol in order to
N É Petushok et al.
Biomeditsinskaia khimiia, 59(1), 76-80 (2013-05-09)
The effects of some ethanol-metabolising systems (aldehyde dehydrogenase, catalase, cytochrome P450 2E1) on activation of lipid peroxidation (LPO) processes in gastrointestinal tract of rats have been studied using inhibitors of these systems. The intensity of LPO processes was evaluated by
C Forn-Frías et al.
Revista de neurologia, 37(5), 485-493 (2003-10-09)
The purpose of this study is to collect and evaluate the experimental evidence suggesting that acetaldehyde, the first oxidative metabolite of ethyl alcohol (ethanol), plays a mediating role in the brain damage associated with the chronic consumption of this substance.
M Apte et al.
Novartis Foundation symposium, 285, 200-211 (2007-06-27)
Alcohol abuse is a major cause of pancreatitis, a condition that can manifest as both acute necroinflammation and chronic damage (acinar atrophy and fibrosis). It is generally accepted that alcohol-induced pancreatic injury is a consequence of the metabolism of alcohol
K M Bekers et al.
Yeast (Chichester, England), 32(8), 541-557 (2015-06-11)
With the current quantitative metabolomics techniques, only whole-cell concentrations of NAD and NADH can be quantified. These measurements cannot provide information on the in vivo redox state of the cells, which is determined by the ratio of the free forms
Kazuhiko Nakamura et al.
Archives of toxicology, 77(10), 591-593 (2003-10-24)
Acetaldehyde binds to some proteins and becomes a Schiff base. It is assumed that after the consumption of ethanol the acetaldehyde binds to the proteins to form adducts, and such acetaldehyde adducts are associated with organ diseases. We investigated the
Jeongyun Choi et al.
Chemosphere, 125, 139-146 (2014-12-31)
This report describes a novel technology of reusing the wastewater discharged from the display manufacturing industry through an advanced oxidation process (AOP) with a metal-immobilized catalyst and reverse osmosis (RO) in the pilot scale. The reclaimed water generated from the
Bing Tao et al.
Journal of hazardous materials, 244-245, 240-250 (2012-12-22)
Metaldehyde removal from aqueous solution was evaluated using granular activated carbon (GAC), a non-functionalised hyper-cross-linked polymer Macronet (MN200) and an ion-exchange resin (S957) with sulfonic and phosphonic functional groups. Equilibrium experimental data were successfully described by Freundlich isotherm models. The
Tracy T Smith et al.
Experimental and clinical psychopharmacology, 22(5), 453-459 (2014-07-08)
Product standards that greatly reduce the content of nicotine within cigarettes may result in improved public health. The study presented here used an animal model to investigate whether individuals who start smoking after implementation of regulation may be affected differently
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