766305

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5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR.

Marek R Baranowski et al.

Nucleic acids research, 48(15), 8209-8224 (2020-06-10)

The high sensitivity of 19F nucleus to changes in the chemical environment has promoted the use of fluorine-labeled molecular probes to study structure and interactions of nucleic acids by 19F NMR. So far, most efforts have focused on incorporating the

Inhibition of glutamate carboxypeptidase by phosphoryl and thiophosphoryl derivatives of glutamic and 2-hydroxyglutaric acid.

Lu H, et al.

Phosph. Sulfur Relat. Elem., 178(1), 17-32 (2003)

Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents.

Seigo Nagata et al.

Nucleic acids research, 38(21), 7845-7857 (2010-07-28)

Though medicines that target mRNA are under active investigation, there has been little or no effort to develop mRNA itself as a medicine. Here, we report the synthesis of a 130-nt mRNA sequence encoding a 33-amino-acid peptide that includes the

Solid-phase synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose.

D?Errico S, et al.

Molecules (Basel), 16(9), 8110-8118 (2011)

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs.

Florian Abele et al.

Biomolecules, 10(4) (2020-04-02)

The complexity of the transcriptome is governed by the intricate interplay of transcription, RNA processing, translocation, and decay. In eukaryotes, the removal of the 5'-RNA cap is essential for the initiation of RNA degradation. In addition to the canonical 5'-N7-methyl

Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.

Renuka Gupte et al.

ChemMedChem, 6(5), 922-935 (2011-04-06)

Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipase D activity, which leads to generation of the growth-factor-like lipid mediator lysophosphatidic acid (LPA). ATX is highly upregulated

Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.

Francois JC, et al.

Proceedings of the National Academy of Sciences of the USA, 86(24), 9702-9706 (1989)

Synthesis from quebrachitol of 1L-chiro-inositol 2, 3, 5-trisphosphate, an inhibitor of the enzymes of 1D-myo-inositol 1, 4, 5-trisphosphate metabolism.

Liu C, et al.

Carbohydrate Research, 234, 107-115 (1992)

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