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显示 1-30 共 87 条结果 关于 "84120" 范围 论文
F C Bach et al.
European cells & materials, 30, 132-146 (2015-09-22)
During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). NCs secrete factors with regenerative potential, making them an interesting focus for regenerative treatments. During initial development, these strategies preferably employ non-human
Tomoko Yamaguchi et al.
Stem cells and development, 22(5), 726-734 (2012-10-11)
Mast cells play important roles in the pathogenesis of allergic diseases. They are generally classified into 2 phenotypically distinct populations: connective tissue-type mast cells (CTMCs) and mucosal-type mast cells (MMCs). The number of mast cells that can be obtained from
F Wegman et al.
European cells & materials, 30, 1-10 (2015-07-28)
Bone morphogenetic protein-2 (BMP-2) gene delivery has shown to induce bone formation in vivo in cell-based tissue engineering. In addition, the chemoattractant stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) is known to recruit multipotent stromal cells towards its release
Lauren N M Hayward et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(4), 567-573 (2012-11-21)
Assessment of the early stages of fracture healing via X-rays and computed tomography is limited by the low radio-opacity of cartilage. We validated a method of contrast-enhanced computed tomography (CECT) for non-destructive identification of cartilage within a healing fracture callus.
Juryun Kim et al.
Journal of Korean medical science, 30(3), 233-239 (2015-03-03)
Eupatilin is the main active component of DA-9601, an extract from Artemisia. Recently, eupatilin was reported to have anti-inflammatory properties. We investigated the anti-arthritic effect of eupatilin in a murine arthritis model and human rheumatoid synoviocytes. DA-9601 was injected into
Alexandra Gonçalves et al.
Acta biomaterialia, 7(4), 1644-1652 (2010-12-07)
Cartilage tissue engineering (TE) typically involves the combination of a 3-D biodegradable polymeric support material, with primary chondrocytes or other cell types able to differentiate into chondrocytes. The culture environment in which cell-material constructs are created and stored is an
Anja Eichner et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(2), 387-396 (2014-11-26)
Highly resistant endospores may cause severe problems in medicine as well as in the food and packaging industries. We found that bacterial endospores can be inactivated quickly with reactive oxygen species (ROS) that were generated by a new generation of
Neethu Mohan et al.
Journal of biomedical materials research. Part A, 103(12), 3896-3906 (2015-05-28)
The study investigated the potential of electrospun fiber assembled hydrogel, with physical gradients of chondroitin sulfate (CS) and sol-gel-derived bioactive glass (BG), to engineer hyaline and mineralized cartilage in a single 3D system. Electrospun poly(caprolactone) (PCL) fibers incorporated with 0.1%
Yamei Liu et al.
Journal of orthopaedic translation, 22, 81-91 (2020-05-23)
Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation
Jan M Suski et al.
Methods in molecular biology (Clifton, N.J.), 810, 183-205 (2011-11-08)
Mitochondria are considered as the main source of reactive oxygen species (ROS) in the cell. For this reason, they have been recognized as a source of various pathological conditions as well as aging. Chronic increase in the rate of ROS
Jonathan Ferrand et al.
PloS one, 6(12), e29007-e29007 (2012-01-05)
The role of bone marrow-derived mesenchymal stem cells (MSC) in the physiology of the gastrointestinal tract epithelium is currently not well established. These cells can be recruited in response to inflammation due to epithelial damage, home, and participate in tissue
T-A N Kelly et al.
Osteoarthritis and cartilage, 17(1), 73-82 (2008-09-23)
To examine the radial variations in engineered cartilage that may result due to radial fluid flow during dynamic compressive loading. This was done by evaluating the annuli and the central cores of the constructs separately. Chondrocyte-seeded agarose hydrogels were grown
Jan Philipp Krüger et al.
Annals of biomedical engineering, 42(12), 2562-2576 (2014-08-30)
In cartilage regeneration, bio-activated implants are used in stem and progenitor cell-based microfracture cartilage repair procedures. Our aim was to analyze the chondrogenic potential of freeze-dried resorbable polymer-based polyglycolic acid (PGA) scaffolds bio-activated with transforming growth factor-β3 (TGFB3) on human
Liliana Rodrigues et al.
Antimicrobial agents and chemotherapy, 57(2), 751-757 (2012-11-21)
Efflux pumps are membrane proteins capable of actively transporting a broad range of substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response to drug treatment may be the first step in the development of
G J Eaton et al.
Cell death & disease, 5, e1522-e1522 (2014-11-14)
Endochondral ossification is the result of chondrocyte differentiation, hypertrophy, death and replacement by bone. The careful timing and progression of this process is important for normal skeletal bone growth and development, as well as fracture repair. Apoptosis Signal-Regulating Kinase 1
Yeonsue Jang et al.
In vitro cellular & developmental biology. Animal, 51(2), 142-150 (2014-11-02)
Bone marrow concentration (BMC) is the most recognized procedure to prepare mesenchymal stem cells for cartilage regeneration. However, bone marrow aspiration is highly invasive and results in low stem cell numbers. Recently, adipose tissue-derived stromal vascular fraction (AT-SVF) was studied
Alexandra I Sorochkina et al.
PloS one, 7(7), e41919-e41919 (2012-08-23)
Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing
Heather A Cole et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(8), 2222-2233 (2014-03-26)
Osteoporosis is a skeletal disorder characterized by low bone mass and increased bone fragility associated with aging, menopause, smoking, obesity, or diabetes. Persistent inflammation has been identified as an instigating factor in progressive bone loss. In addition to the role
Conn's Biological Stains
Kiernan & Horobin
Conn?s Biological Stains (2002)
Holly A Leddy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(6), 2525-2537 (2014-03-01)
Point mutations in the calcium-permeable TRPV4 ion channel have been identified as the cause of autosomal-dominant human motor neuropathies, arthropathies, and skeletal malformations of varying severity. The objective of this study was to determine the mechanism by which TRPV4 channelopathy
Justine Guet et al.
Journal of experimental botany, 66(15), 4643-4652 (2015-05-17)
Xylem resistance to drought-induced cavitation is a key trait of plant water relations. This study assesses the genetic variation expressed for stem cavitation resistance within a population of a riparian species, the European black poplar (Populus nigra L.), and explores
Manos Stefanakis et al.
Spine, 37(22), 1883-1891 (2012-06-19)
Mechanical and biochemical analyses of cadaveric and surgically removed discs. To test the hypothesis that fissures in the annulus of degenerated human discs are mechanically and chemically conducive to the ingrowth of nerves and blood vessels. Discogenic back pain is
Jianchao Gui et al.
Current stem cell research & therapy, 10(4), 353-363 (2015-05-20)
The successful surgical restoration of damaged meniscus has been a challenge, largely owing to a lack of characterization of meniscus cells and their precursors. Numerous strategies to repair or replace meniscus have achieved only limited success. Several recent studies have
I L Erokhina et al.
Tsitologiia, 53(1), 39-43 (2011-04-09)
Multifunctional granular mast cells (MCs) are involved in various pathological processes. The response of MC populations of myocardium, pericardium and lung to pulmonary hypertension (PH) has been studies 8 weeks after injection of monocrotaline. Five intact and five experimental rats
Zhe Zhang et al.
International journal of molecular sciences, 16(11), 25934-25946 (2015-11-04)
Bone morphogenetic proteins (BMPs) play important roles in skeletal development and repair. Previously, we found fibroblast growth factor 2 (FGF2) induced up-regulation of BMP2, 3, 4 in the process of rabbit articular cartilage repair, which resulted in satisfactory repair effects.
Berenice Fernández-Rojas et al.
Molecular and cellular biochemistry, 406(1-2), 183-197 (2015-05-15)
The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate
Cecilia Granéli et al.
Stem cell research, 12(1), 153-165 (2013-11-19)
Today, the tool that is most commonly used to evaluate the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro is the demonstration of the expression of multiple relevant markers, such as ALP, RUNX2 and OCN. However, as yet
Tao Qiu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(2), 309-317 (2014-09-10)
Longitudinal growth of postnatal bone requires precise control of growth plate cartilage chondrocytes and subsequent osteogenesis and bone formation. Little is known about the role of angiogenesis and bone remodeling in maintenance of cartilaginous growth plate. Parathyroid hormone (PTH) stimulates
Yee Suan Poo et al.
Journal of virology, 88(12), 6862-6872 (2014-04-04)
Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments. Arthritic disease is usually characterized by high levels of the
Pengfei Hu et al.
International journal of clinical and experimental pathology, 7(10), 6575-6584 (2014-11-18)
Cordycepin is widely used as for its various pharmacological activities, such as anti-inflammation, anti-angiogenesis, anti-aging, anti-tumor and anti-proliferation. However, the precise role of cordycepin on chondrocytes is not clear. In the present study, we examined the inhibitory effects of cordycepin
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