858143P

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Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control.

Takafumi Matsumura et al.

Scientific reports, 11(1), 3458-3458 (2021-02-12)

In vitro spermatogenesis (IVS) using air-liquid interphase organ culture method is possible with mouse testis tissues. The same method, however, has been hardly applicable to animals other than mice, only producing no or limited progression of spermatogenesis. In the present

The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

Varela Chavez C, et al.

Cellular Microbiology, 17(10), 1477-1493 (2015)

Jung Yong Eum et al.

Journal of chromatography. A, 460849-460849 (2020-01-14)

Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to

Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis.

Masako Nishikawa et al.

Journal of atherosclerosis and thrombosis, 22(5), 518-526 (2014-12-03)

Lysophospholipids, particularly sphingosine 1-phosphate and lysophosphatidic acid, are known to be involved in the pathogenesis of atherosclerosis; however, the role of lysophosphatidylserine (LysoPS) in the onset of atherosclerotic diseases remains uncertain. We investigated the effects of LysoPS on the uptake

The metabolic change in serum lysoglycerophospholipids intervened by triterpenoid saponins from Kuding tea on hyperlipidemic mice.

Qingxin Shi et al.

Food & function, 10(12), 7782-7792 (2019-11-30)

Triterpenoid saponins from Kuding tea have demonstrated preventive effects on hyperlipidaemia induced by a high-fat diet. Lysoglycerophospholipids (Lyso-GPLs) are known to be associated with proatherogenic conditions such as hyperlipidaemia. In this study, a target profiling strategy based on a multiple

Lysophosphatidylcholine enhances NGF-induced MAPK and Akt signals through the extracellular domain of TrkA in PC12 cells.

Wuhanqimuge et al.

FEBS open bio, 3, 243-251 (2013-06-19)

Lysophosphatidylcholine (LPC) is one of the major lysophospholipids mainly generated by phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC). We previously found that LPC displays neurotrophin-like activity in the rat pheochromocytoma PC12 cells and in cerebellar granule neurons, but the molecular

Metabolic control of cytosolic-facing pools of diacylglycerol in budding yeast.

Suriakarthiga Ganesan et al.

Traffic (Copenhagen, Denmark), 20(3), 226-245 (2018-12-21)

Diacylglycerol (DAG) is a key signaling lipid and intermediate in lipid metabolism. Our knowledge of DAG distribution and dynamics in cell membranes is limited. Using live-cell fluorescence microscopy we investigated the localization of yeast cytosolic-facing pools of DAG in response

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