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Gregory Kaler et al.
The Journal of biological chemistry, 282(33), 23841-23853 (2007-06-08)
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of
Carlota Tayà et al.
Biotechnology and bioengineering, 110(2), 391-400 (2012-08-14)
The presence of suitable carbon sources for enhanced biological phosphorus removal (EBPR) plays a key role in phosphorus removal from wastewater in urban WWTP. For wastewaters with low volatile fatty acids (VFAs) content, an external carbon addition is necessary. As
Yinguang Chen et al.
Water research, 47(2), 615-622 (2012-12-12)
Volatile fatty acids (VFA) can be used as the additional carbon source of biological nutrient removal (BNR), and the increase of propionic acid percentage in VFA has been reported to facilitate the performance of BNR. In this study a new
Harry Michael Falk et al.
Bioprocess and biosystems engineering, 38(2), 237-249 (2014-08-22)
An ATR-MIR-FTIR spectrometer was integrated into a laboratory scale anaerobic digestion setup. Automatically, a sludge sample from the digester was transferred to a measurement cell; an IR spectrum was recorded and evaluated by chemometric models to estimate the concentration of
B D Ridge et al.
The British journal of dermatology, 118(2), 167-174 (1988-02-01)
Using a hypomitotic agent, triamcinolone acetonide, and a hypermitotic agent, retinyl propionate, we investigated the relationship between epidermal mitotic activity and stratum corneum renewal time of topically treated skin as determined by the dansyl chloride staining technique. Treatment with the
B C Bernhard et al.
Journal of animal science, 90(13), 4857-4865 (2012-10-11)
Crossbred steers (n = 20; 235 ± 4 kg) were fed for 53 d during a receiving period to determine if supplementing chromium (Cr; KemTRACE Chromium Propionate 0.04%, Kemin Industries, Des Moines, IA) would alter glucose or lipid metabolism of
Tomoko Ariga et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 48-53 (2015-02-07)
Iron (Fe) is an essential element for higher plants, which take it up from the soil at the root surface and transport it to shoots through the xylem. Fe(III) chelators, such as organic acids and phytosiderophores, play important roles in
Sorption and solubility of self-etching adhesives immersed in organic acids present in oral biofilm.
Maria Elisa da Silva Nunes Gomes Miranda et al.
The journal of adhesive dentistry, 16(2), 115-122 (2014-04-01)
This study evaluated the sorption and solubility of self-etching adhesive systems after immersion in distilled water, lactic acid, and propionic acid. Specimens of 2 two-step (P90 System Adhesive [P90], Clearfil SE Bond [CSE]) and 1 single-step (Adper Easy One [AEO])
Sumit Bhatnagar et al.
Journal of pharmaceutical sciences, 103(10), 3276-3286 (2014-07-23)
Low and heterogeneous delivery of drugs and imaging agents to tumors results in decreased efficacy and poor imaging results. Systemic delivery involves a complex interplay of drug properties and physiological factors, and heterogeneity in the tumor microenvironment makes predicting and
Xian-Bing Xu et al.
Journal of chromatography. A, 1366, 65-72 (2014-09-24)
A novel interface that enables high-performance anion-exchange chromatography (HPAEC) to be coupled with electrospray ionization (ESI) mass spectrometry (MS) is reported. A sheath liquid consisting of 50mM NH4Ac in isopropanol with 0.05% acetic acid, infused at a flow rate of
The many roles for fluorine in medicinal chemistry.
William K Hagmann
Journal of medicinal chemistry, 51(15), 4359-4369 (2008-06-24)
Bo Tjellström et al.
Scandinavian journal of gastroenterology, 47(12), 1454-1459 (2012-09-29)
Exclusive enteral nutrition (EEN) is a first-line treatment in children with active Crohn's disease (CD) but is seldom used in adults with active disease. The mode of action of EEN in suppressing mucosal inflammation is not fully understood, but modulation
Ewelina Król et al.
Biological trace element research, 150(1-3), 350-359 (2012-10-16)
Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity. Nutrients, such as microelement chromium(III) and thiamine, play regulatory roles
Shih-Chun Lin et al.
Glia, 47(3), 290-298 (2004-07-15)
Rapid signaling between vertebrate neurons occurs primarily at synapses, intercellular junctions where quantal release of neurotransmitter triggers rapid changes in membrane conductance through activation of ionotropic receptors. Glial cells express many of these same ionotropic receptors, yet little is known
Yang Liu et al.
Molecular pharmaceutics, 11(10), 3330-3341 (2014-06-26)
Achieving effective gene therapy for glioma depends on gene delivery systems. The gene delivery system should be able to cross the blood-brain barrier (BBB) and further target glioma at its early stage. Active brain tumor targeted delivery can be achieved
S Somerma et al.
Acta dermato-venereologica, 64(1), 41-45 (1984-01-01)
The effect of five corticosteroid ointments on epidermal thickness was studied using occlusive chamber application. Thinning of the epidermis and telangiectasia were noted 3 weeks after application of betamethasone-17-valerate (BV), budesonide (BD), clobetasol-17-propionate (CP), and fluocinolone acetonide (FA), but not
Pengyuan Sun et al.
Pharmacological reports : PR, 66(2), 311-319 (2014-06-10)
Eprosartan is an angiotensin II receptor antagonist, used in the treatment of hypertension and heart failure in clinical patients. The objective of this study was to clarify the mechanism underlying hepatic uptake and biliary excretion of eprosartan in rats and
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
Bachir Latli et al.
Journal of labelled compounds & radiopharmaceuticals, 57(5), 350-357 (2014-04-05)
Drug candidates labeled with radioactive and stable isotopes are required for absorption, distribution, metabolism, and excretion (ADME) studies, pharmacokinetics, autoradiography, bioanalytical, and other research activities. The findings from these studies are crucial in the development of a drug candidate and
Wojciech Ostrowski et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 21-27 (2014-07-27)
Liquid chromatography coupled to mass spectrometry (MS) with electrospray ionization (ESI) is one of analytical techniques to obtain accurate results of low molecular weight aromatic compounds in biological samples of different origin. The interpretations of mass spectra of these aromatic
Luc M LeBlanc et al.
Molecules (Basel, Switzerland), 17(12), 14637-14650 (2012-12-12)
Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the
R A Koeppe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19(10), 1150-1163 (1999-10-26)
N-[11C]Methylpiperidin-4-yl propionate ([11C]PMP) is a substrate for hydrolysis by acetylcholinesterase (AChE). This work evaluates kinetic analysis alternatives for estimation of relative AChE activity using dynamic positron emission tomography (PET) studies of [11C]PMP. The PET studies were performed on three groups
Maria F Mendoza et al.
Biochemistry, 51(40), 8014-8026 (2012-09-20)
NAD(P)H:quinone oxidoreductase type I (NQO1) is a target enzyme for triggered delivery of drugs at inflamed tissue and tumor sites, particularly those that challenge traditional therapies. Prodrugs, macromolecules, and molecular assemblies possessing trigger groups that can be cleaved by environmental
Nadja Mannowetz et al.
PloS one, 7(7), e41030-e41030 (2012-08-23)
To reach the egg in the ampulla, sperm have to travel along the female genital tract, thereby being dependent on external energy sources and substances to maintain and raise the flagellar beat. The vaginal fluid is rich in lactate, whereas
Sheena N Smith et al.
Nature communications, 5, 5223-5223 (2014-11-08)
Binding of a T-cell receptor (TCR) to a peptide/major histocompatibility complex is the key interaction involved in antigen specificity of T cells. The recognition involves up to six complementarity determining regions (CDR) of the TCR. Efforts to examine the structural
Oleg M Alekseev et al.
The Journal of biological chemistry, 280(4), 2904-2911 (2004-11-10)
NASP (nuclear autoantigenic sperm protein) is a linker histone-binding protein found in all dividing cells that is regulated by the cell cycle (Richardson, R. T., Batova, I. N., Widgren, E. E., Zheng, L. X., Whitfield, M., Marzluff, W. F., and
Randy J Chandler et al.
Molecular genetics and metabolism, 89(1-2), 64-73 (2006-07-18)
We have utilized Caenorhabditis elegans to study human methylmalonic acidemia. Using bioinformatics, a full complement of mammalian homologues for the conversion of propionyl-CoA to succinyl-CoA in the genome of C. elegans, including propionyl-CoA carboxylase subunits A and B (pcca-1, pccb-1)
Elena Herzog et al.
Biophysical journal, 103(6), 1305-1314 (2012-09-22)
The E-pathway of transmembrane proton transfer has been demonstrated previously to be essential for catalysis by the diheme-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes. Two constituents of this pathway, Glu-C180 and heme b(D) ring C (b(D)-C-) propionate, have been validated
Sa'ad H Al-Lahham et al.
Biochimica et biophysica acta, 1801(11), 1175-1183 (2010-08-10)
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the principal metabolites produced. However, most of the literature focuses on butyrate
Barbara Pavan et al.
Life sciences, 121, 166-173 (2014-12-06)
The ability of the plant flavonol quercetin and its conjugated form quercetin-3-glucoside, compared to that of the anthocyanin cyanidin-3-glucoside, to interfere with 3',5'-cyclic adenosine monophosphate (cAMP) efflux was investigated in cultured human retinal pigment epithelial (HRPE) cells. HRPE cells were
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