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A2153
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Masako Abe et al.
BMC cancer, 11, 51-51 (2011-02-03)
CD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers. Our work evaluates the mechanism involved in confluence-dependent CD26 expression in colon cancer. Colon
Marten Szibor et al.
The Journal of biological chemistry, 295(14), 4383-4397 (2020-02-26)
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activation of matrix dehydrogenases, thereby matching OXPHOS substrate supply
Emilie Gontran et al.
Bioengineering (Basel, Switzerland), 8(8) (2021-08-27)
Globally, liver diseases account for 2 million deaths per year. For those with advanced liver disease the only curative approach is liver transplantation. However, less than 10% of those in need get a liver transplant due to limited organ availability.
Dhébora Albuquerque Dias et al.
Cell biochemistry and function, 35(7), 358-363 (2017-09-06)
This study aimed to characterize the activity of ectonucleoside triphosphate diphosphohydrolase (E-NTPDase; EC 3.6.1.5) in peritoneal cavity cells from BALB/c mice. E-NTPDase was activated in the presence of both calcium (1.5mM) and magnesium (1.5mM) ions. However, the activity was higher
Alice Abend et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Coupling of cells to biomaterials is a prerequisite for most biomedical applications; e.g., neuroelectrodes can only stimulate brain tissue in vivo if the electric signal is transferred to neurons attached to the electrodes' surface. Besides, cell survival in vitro also
Romina Muñoz et al.
PloS one, 12(12), e0189979-e0189979 (2017-12-22)
The accurate characterization of proteins in both their native and denatured states is essential to effectively understand protein function, folding and stability. As a proof of concept, a micro rheological method is applied, based on the characterization of thermal fluctuations
Linghua Xie et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2022-12-17)
The ventrolateral periaqueductal gray (vlPAG) collaborates with the dorsal raphe (DR) in pain regulation and emotional response. However, the roles of vlPAG and DR γ-aminobutyric acid (GABA)-ergic neurons in regulating nociception and anxiety are contradictory and poorly understood. Here, we
Eleonora Dal Sasso et al.
ACS biomaterials science & engineering, 6(10), 5493-5506 (2020-12-16)
Heart failure is the worst outcome of all cardiovascular diseases and still represents nowadays the leading cause of mortality with no effective clinical treatments, apart from organ transplantation with allogeneic or artificial substitutes. Although applied as the gold standard, allogeneic
Vahid Siavashi et al.
Journal of cellular biochemistry, 117(8), 1934-1946 (2016-01-13)
Preserving self-renewal, multipotent capacity, and large-scale expansion of highly functional progenitor cells, including endothelial progenitor cells (EPCs), is a controversial issue. These current limitations, therefore, raise the need of developing promising in vitro conditions for prolonged expansion of EPCs without
Jaeyong Jung et al.
Biochip journal, 15(4), 396-405 (2021-09-02)
Several endemic corona viruses (eCoVs) have been reported to be the most common etiologic agents for the seasonal common cold and also cause pneumonia. These eCoVs share extensive sequence homology with SARS-CoV-2, and immune responses to eCoVs can cross-react with
Tarek Aboushousha et al.
Asian Pacific journal of cancer prevention : APJCP, 21(2), 547-554 (2020-02-28)
Bladder cancer represents a global health problem. It ranks ninth in worldwide cancer incidence. In Egypt, carcinoma of the bladder is the most prevalent cancer, Bladder cancer has the highest recurrence rate of any malignancy. Certainly, suitable molecular diagnostic markers
Max Brown et al.
Molecular biology of the cell, 31(23), 2597-2629 (2020-09-03)
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates a signaling network known as the unfolded protein response (UPR). Here we characterize how ER stress and the UPR inhibit insulin signaling. We find that ER
Saya Moriyama et al.
Immunity, 54(8), 1841-1852 (2021-07-12)
Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time affects antibody potency. To assess the impact of antibody maturation on durable neutralizing activity against original SARS-CoV-2 and emerging variants of concern (VOCs), we analyzed receptor binding
Nikos Koundouros et al.
Cell, 181(7), 1596-1611 (2020-06-20)
Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife to sample the aerosol of cauterized specimens, we demonstrate a new mode
Yu-Ju Kuo et al.
Toxins, 12(7) (2020-07-02)
Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decrease degradation and reduces renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal PEGylation technique was used to modify the disintegrin derivative [KGDRR]trimucrin for favorable safety
Niva Yacov et al.
Basic & clinical pharmacology & toxicology, 124(2), 131-143 (2018-08-21)
Focal segmental glomerulosclerosis (FSGS) is a scarring process associated with chronic low-grade inflammation ascribed to toll-like receptor (TLR) activation and monocyte migration. We developed synthetic, small-molecule lecinoxoids, VB-201 and VB-703, that differentially inhibit TLR-2- and TLR-4-mediated activation and monocyte migration.
Ophélia Le Thuc et al.
Bio-protocol, 7(16), e2521-e2521 (2017-08-20)
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and the periphery. The hypothalamus itself can be considered an endocrine
Mar Bosch-Queralt et al.
STAR protocols, 3(1), 101141-101141 (2022-02-11)
Lysolecithin injections into the white matter tracts of the central nervous system are a valuable tool to study remyelination, but evaluating the resulting demyelinating lesion size is challenging. Here, we present a protocol to consistently measure the volume of demyelination
Löms Ziegler-Heitbrock et al.
Journal of immunology (Baltimore, Md. : 1950), 171(1), 285-290 (2003-06-21)
The anti-inflammatory cytokine IL-10 can be induced by type I IFNs, but the molecular mechanisms involved have remained elusive. With in silico analysis of the human IL-10 promoter we identified a module consisting of an IFN regulatory factor 1 (IRF-1)
Nike Walther et al.
The Journal of cell biology, 217(7), 2309-2328 (2018-04-11)
The two Condensin complexes in human cells are essential for mitotic chromosome structure. We used homozygous genome editing to fluorescently tag Condensin I and II subunits and mapped their absolute abundance, spacing, and dynamic localization during mitosis by fluorescence correlation
Di Qi et al.
International journal of molecular medicine, 40(6), 1803-1817 (2017-10-19)
Acute respiratory distress syndrome (ARDS) is characterized by uncontrolled extravasation of protein‑rich fluids, which is caused by disruption and dysfunction of the barrier of pulmonary endothelial cells (ECs). Visceral adipose tissue‑derived serine protease inhibitor (vaspin) is a novel adipokine with
Rolf Herrmann et al.
PloS one, 6(11), e27573-e27573 (2011-11-19)
RGS9 and R9AP are components of the photoreceptor-specific GTPase activating complex responsible for rapid inactivation of the G protein, transducin, in the course of photoresponse recovery from excitation. The amount of this complex in photoreceptors is strictly dependent on the
Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic Mammary Gland.
Qiang Lan et al.
Journal of mammary gland biology and neoplasia, 25(4), 409-416 (2020-10-04)
Branching morphogenesis of the murine mammary gland starts during late embryogenesis. It is regulated by the signals emanating both from the epithelium and the mesenchyme, yet the molecular mechanisms regulating this process remain poorly understood. We have previously developed a
Marta Chiavari et al.
Brain sciences, 9(5) (2019-05-18)
: The characterization of human microglia has been hampered by poor availability of human cell sources. However, microglia is involved in the physiopathology of multiple sclerosis, Alzheimer's disease, Parkinson's disease, HIV dementia, retinal degenerative diseases, cancer, and many other conditions.
Steven Droho et al.
Investigative ophthalmology & visual science, 60(15), 5059-5069 (2019-12-05)
Beta-adrenergic receptor (AR) antagonists, like propranolol, inhibit angiogenesis in multiple ocular conditions through an unknown mechanism. We previously showed that propranolol reduces choroidal neovascularization (CNV) by decreasing interleukin-6 levels. Since macrophages are one of the central producers of interleukin-6, we
Devin Harrison et al.
STAR protocols, 2(3), 100807-100807 (2021-09-17)
Heterogeneous metabolism supports critical single-cell functions. Here, we describe deep-learning-enabled image analyses of a genetically encoded lactate-sensing probe which can accurately quantify metabolite levels and glycolytic rates at the single-cell level. Multiple strategies and test data have been included to
Heather M McGee et al.
Immunology and cell biology, 89(7), 767-776 (2011-01-19)
Neonates have a developing immune response, with a predisposition towards induction of tolerance. As the immune system develops, immunity rather than tolerance is induced, with this development of immunity occurring in response to external factors such as the environment. As
Marlena Zielinska et al.
International journal of nanomedicine, 6, 3163-3172 (2012-01-13)
It was hypothesized that heparan sulfate (HS) as an essential compound for myogenesis and nanoparticles of gold (nano-Au) as highly reactive compounds can affect muscle development as a consequence of molecular regulation of muscle cell formation, and that these effects
A A Troussard et al.
The Journal of biological chemistry, 270(29), 17068-17071 (1995-07-21)
Adenovirus vector-mediated transfer of the receptor-associated protein (RAP) gene into low density lipoprotein (LDL) receptor-deficient mice was shown to achieve plasma concentrations ranging between 20 and 200 micrograms/ml and to result in the accumulation of remnant lipoproteins (Willnow, T. E.
Sao Puth et al.
Mucosal immunology, 12(2), 565-579 (2018-11-30)
Periodontitis is associated with a dysbiotic shift in the oral microbiome. Vaccine approaches to prevent microbial shifts from healthy to diseased state in oral biofilms would provide a fundamental therapeutic strategy against periodontitis. Since dental plaque formation is a polymicrobial
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