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Xiaoqing Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 118, 109258-109258 (2019-09-24)
Gypenosides (GP) are a type of traditional Chinese medicine (TCM) extracted from plants and commonly applied for treatment of metabolic diseases. This study aims to explore the effects of GP extracts on alleviating non-alcoholic fatty liver disease (NAFLD). In this
Robert J Andrew et al.
Journal of neurochemistry, 149(3), 399-412 (2019-01-22)
The generation of the amyloid-β (Aβ) peptides from the amyloid precursor protein (APP) through sequential proteolysis by β- and γ-secretases is a key pathological event in the initiation and propagation of Alzheimer's disease. Aβ and the transcriptionally active APP intracellular
Snigdha Shaw et al.
Scientific reports, 10(1), 3458-3458 (2020-02-28)
The underlying mechanism regulating hypoxia induced alteration in female steroid hormones is first time explored in this study. To understand the mechanistic approach, female Sprague- Dawley rats were exposed to acute and chronic hypobaric hypoxia (282 mm-Hg, ~7620 m, 6 hours, 3 and
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events
Debdatto Mookherjee et al.
Autophagy, 17(7), 1729-1752 (2020-06-20)
Turnover of cellular organelles, including endoplasmic reticulum (ER) and mitochondria, is orchestrated by an efficient cellular surveillance system. We have identified a mechanism for dual regulation of ER and mitochondria under stress. It is known that AMFR, an ER E3
Carlotta Pontremoli et al.
Journal of colloid and interface science, 563, 92-103 (2019-12-24)
The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a radical improvement of the existing therapeutic approach through the design of
Kerstin Harnack et al.
Nutrition & metabolism, 6, 8-8 (2009-02-21)
Conversion of linoleic acid (LA) and alpha-linolenic acid (ALA) to their higher chain homologues in humans depends on the ratio of ingested n6 and n3 fatty acids. In order to determine the most effective ratio with regard to the conversion
Dvir Gur et al.
Nature communications, 11(1), 6391-6391 (2020-12-16)
Skin color patterns are ubiquitous in nature, impact social behavior, predator avoidance, and protection from ultraviolet irradiation. A leading model system for vertebrate skin patterning is the zebrafish; its alternating blue stripes and yellow interstripes depend on light-reflecting cells called
Yin Chen et al.
Macromolecular bioscience, 15(3), 426-436 (2014-11-26)
Microgrooved thin PLGA film (≈30 μm) is successfully fabricated on a Teflon mold, which could be readily peeled off and is used for the construction of a biomimetic cardiac patch. The contraction of it is studied with optical mapping on transmembrane
Essowè Mouzou et al.
Materials science & engineering. C, Materials for biological applications, 61, 564-573 (2016-02-04)
High manganese austenitic steels such as Fe-20Mn-1.2C alloys are among the most promising candidates for biodegradable stents applications due to their high strength, high ductility and their chemical composition. In the current work, 14 day static in-vitro tests were performed
Ester Polo et al.
Methods in molecular biology (Clifton, N.J.), 1051, 149-163 (2013-08-13)
Multiple antibody immobilization methodologies have been developed for several applications including affinity chromatography, immunosensing, and drug delivery. Most of them have been carried out without considering the orientation of the antigen binding site of the antibody, or after the chemical
Irene Pallucchi et al.
Cell reports, 39(2), 110654-110654 (2022-04-14)
Locomotion is mediated by spinal circuits that generate movements with a precise coordination and vigor. The assembly of these circuits is defined early during development; however, whether their organization and function remain invariant throughout development is unclear. Here, we show
Claudia X Dominguez et al.
Cancer discovery, 10(2), 232-253 (2019-11-09)
With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic ductal adenocarcinoma (PDAC) progression in animal models. We identify a
Ali Jahanban-Esfahlan et al.
International journal of biological macromolecules, 138, 602-617 (2019-07-19)
Albumin is a globular protein which plays a pivotal role in maintaining plasma pressure and the nutritional balance. Different compounds are transported by binding to albumin in the blood. Also, human health is closely related to the serum albumin concentration
Kaitai Liu et al.
Journal of clinical laboratory analysis, 34(1), e23026-e23026 (2019-09-20)
Chitinase 3-like protein 1 (CHI3L1) is most likely a malignant tumor metastasis-associated gene. However, the functions of CHI3L1 in colon cancer cell proliferation and its cetuximab sensitivity are still unclear. We aimed to investigate the mechanism of CHI3L1 in promoting
Yingshi Ouyang et al.
mSphere, 6(2) (2021-04-16)
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a massive impact on human lives worldwide. While the airborne SARS-CoV-2 primarily affects the lungs, viremia is not uncommon. As placental trophoblasts are
Ayantika Sen Gupta et al.
Nucleus (Austin, Tex.), 9(1), 350-367 (2018-06-27)
Eukaryotic cells have 2 to 3 discrete nucleoli required for ribosome synthesis. Nucleoli are phase separated nuclear sub-organelles. Here we examined the role of nuclear Lamins and nucleolar factors in modulating the compartmentalization and dynamics of histone 2B (H2B-ECFP) in
Marion Robin et al.
Autophagy, 15(5), 771-784 (2018-12-20)
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and
Justin A Boddey et al.
Traffic (Copenhagen, Denmark), 10(3), 285-299 (2008-12-06)
The intracellular survival of Plasmodium falciparum within human erythrocytes is dependent on export of parasite proteins that remodel the host cell. Most exported proteins require a conserved motif (RxLxE/Q/D), termed the Plasmodium export element (PEXEL) or vacuolar targeting sequence (VTS)
DNA-binding mechanism and evolution of replication protein A.
Madru, et al.
Nature Communications, 14, 2326-2326 (2023)
Abubakar Wani et al.
Autophagy, 15(10), 1810-1828 (2019-03-22)
Imbalance in production and clearance of amyloid beta (Aβ) is the primary reason for its deposition in Alzheimer disease. Macroautophagy/autophagy is one of the important mechanisms for clearance of both intracellular and extracellular Aβ. Here, through screening, we identified alborixin
Soňa Legartová et al.
Cells, 10(2) (2021-02-05)
The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein. We observed that inhibitor of
Yiling Zhang et al.
Neuron, 103(1), 39-51 (2019-05-28)
Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth-factor responsiveness in mature neurons by dedifferentiation, we overexpressed Lin28 in the retina. Lin28-treated retinas responded to insulin-like
Ia Khmaladze et al.
Journal of cosmetic dermatology, 19(6), 1415-1425 (2019-10-05)
High demand on anti-aging skin care encourage the improvement and development of more personalized formulations with additional benefits for general skin health and age associated skin signs. The skin aging physical and biological phenotypes manifest differently between diverse ethnic populations.
XiTing Lian et al.
iScience, 26(4), 106284-106284 (2023-03-28)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among epilepsy patients. However, the underlying mechanism remains elusive. Seizure-induced respiratory arrest (S-IRA) is recognized as a main cause of SUDEP, but the contribution of other factors such
Hakan Sahin et al.
ACS chemical neuroscience, 13(13), 1923-1937 (2022-06-18)
Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory. Although the intranasal (IN) administration of oxytocin (OT) has limited efficiency, nanoparticles (NPs) are a promising
Jacquelyn Rose Dayton et al.
Journal of neuroscience methods, 318, 17-33 (2019-02-25)
Current methods for murine brain microvasculature isolation requires the pooling of brain cortices while disregarding the rest of the CNS, making the analysis of single individuals non feasible. Efficient isolation of brain microvessels requires the elimination of meninges, vessels of
Daniela Sotomayor-Gerding et al.
Polymers, 14(23) (2022-12-12)
The development of fish oral vaccines is of great interest to the aquaculture industry due to the possibility of rapid vaccination of a large number of animals at reduced cost. In a previous study, we evaluated the effect of alginate-encapsulated
The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage.
Amirova, et al.
International Journal of Molecular Sciences, 24 (2023)
Chieko Kishi-Itakura et al.
Methods in molecular biology (Clifton, N.J.), 1759, 29-39 (2017-04-01)
In this chapter we describe the use of correlative light-electron microscopy (CLEM) to study, in cultured cells, the turnover of damaged mitochondria by PINK1/Parkin-dependent mitophagy. CLEM combines the advantages of light microscopy, which allows to image and rapidly screen a
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