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DNA-binding mechanism and evolution of replication protein A.
Madru, et al.
Nature Communications, 14, 2326-2326 (2023)
Abubakar Wani et al.
Autophagy, 15(10), 1810-1828 (2019-03-22)
Imbalance in production and clearance of amyloid beta (Aβ) is the primary reason for its deposition in Alzheimer disease. Macroautophagy/autophagy is one of the important mechanisms for clearance of both intracellular and extracellular Aβ. Here, through screening, we identified alborixin
Elizabeth Oliver et al.
BMC biology, 19(1), 212-212 (2021-09-25)
Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is often limited. We have previously detailed a three-dimensional culture model termed the three-layer gradient
HaiXiang Ma et al.
iScience, 25(10), 105228-105228 (2022-10-22)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among patients with epilepsy. However, the underlying mechanism of SUDEP remains elusive. Previous studies showed seizure-induced respiratory arrest (S-IRA) is the main factor in SUDEP, and that enhancement
Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates.
Collett, et al.
Frontiers in Microbiology, 14, 1065609-1065609 (2023)
Mano Sivaganesan et al.
BMC bioinformatics, 9, 120-120 (2008-02-27)
In real-time quantitative PCR studies using absolute plasmid DNA standards, a calibration curve is developed to estimate an unknown DNA concentration. However, potential differences in the amplification performance of plasmid DNA compared to genomic DNA standards are often ignored in
Ia Khmaladze et al.
Journal of cosmetic dermatology, 19(6), 1415-1425 (2019-10-05)
High demand on anti-aging skin care encourage the improvement and development of more personalized formulations with additional benefits for general skin health and age associated skin signs. The skin aging physical and biological phenotypes manifest differently between diverse ethnic populations.
Tamara Topală et al.
Clujul medical (1957), 87(4), 215-219 (2014-01-01)
The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum
Nadezda Zhdanovskaya et al.
Cancers, 14(23) (2022-12-12)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy considered curable by modern clinical management. Nevertheless, the prognosis for T-ALL high-risk cases or patients with relapsed and refractory disease is still dismal. Therefore, there is a keen interest in
Xiaoqing Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 118, 109258-109258 (2019-09-24)
Gypenosides (GP) are a type of traditional Chinese medicine (TCM) extracted from plants and commonly applied for treatment of metabolic diseases. This study aims to explore the effects of GP extracts on alleviating non-alcoholic fatty liver disease (NAFLD). In this
Jiangshan Wang et al.
MethodsX, 8, 101586-101586 (2021-11-30)
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused unprecedented damage to the global economy. Diagnostic testing is a key factor in limiting virus transmission and safeguarding public health. We present the fabrication process of
Guanying Zhang et al.
International immunopharmacology, 91, 107297-107297 (2020-12-29)
Clostridium tetani causes life-threatening disease by producing tetanus neurotoxin (TeNT), one of the most toxic protein substances. Toxicosis can be prevented and cured by administration of anti-TeNT neutralizing antibodies. Here, we identified a series of monoclonal antibodies (mAbs) derived from
Gillian P Johnson et al.
Endocrinology, 163(12) (2022-10-07)
Follicle-stimulating hormone (FSH) is a key endocrine regulator of ovarian function. FSH is secreted as 2 macroglycosylation variants: partially glycosylated FSH (FSH21/18) and fully glycosylated FSH (FSH24). FSH21/18 is more potent than FSH24 at binding to and activating the FSH
Kaitai Liu et al.
Journal of clinical laboratory analysis, 34(1), e23026-e23026 (2019-09-20)
Chitinase 3-like protein 1 (CHI3L1) is most likely a malignant tumor metastasis-associated gene. However, the functions of CHI3L1 in colon cancer cell proliferation and its cetuximab sensitivity are still unclear. We aimed to investigate the mechanism of CHI3L1 in promoting
Raquel V G de Castro et al.
Stem cells international, 2020, 8814989-8814989 (2021-01-19)
The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental oxygen concentration), and the aging process. Herein, we aimed to generate and maintain equine iPSCs (eiPSCs) derived from fibroblasts
Tomo Daidoji et al.
Journal of virology, 82(22), 11294-11307 (2008-09-13)
In recent years, the highly pathogenic avian influenza virus H5N1 has raised serious worldwide concern about an influenza pandemic; however, the biology of H5N1 pathogenesis is largely unknown. To elucidate the mechanism of H5N1 pathogenesis, we prepared primary airway epithelial
Soňa Legartová et al.
Cells, 10(2) (2021-02-05)
The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein. We observed that inhibitor of
Ayantika Sen Gupta et al.
Nucleus (Austin, Tex.), 9(1), 350-367 (2018-06-27)
Eukaryotic cells have 2 to 3 discrete nucleoli required for ribosome synthesis. Nucleoli are phase separated nuclear sub-organelles. Here we examined the role of nuclear Lamins and nucleolar factors in modulating the compartmentalization and dynamics of histone 2B (H2B-ECFP) in
Anielle L Gomes et al.
Frontiers in cell and developmental biology, 8, 711-711 (2020-08-28)
Genomic instability in the central nervous system (CNS) is associated with defective neurodevelopment and neurodegeneration. Congenital human syndromes that affect the CNS development originate from mutations in genes of the DNA damage response (DDR) pathways. RINT1 (Rad50-interacting protein 1) is
Melissa Ellermann et al.
Cell, 183(3), 650-665 (2020-10-09)
Endocannabinoids are host-derived lipid hormones that fundamentally impact gastrointestinal (GI) biology. The use of cannabis and other exocannabinoids as anecdotal treatments for various GI disorders inspired the search for mechanisms by which these compounds mediate their effects, which led to
Lucia Polletta et al.
Autophagy, 11(2), 253-270 (2015-02-24)
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent
Eun Jeong Cho et al.
SLAS discovery : advancing life sciences R & D, 23(1), 1-10 (2017-08-19)
A high rate of glycolysis, which supplies energy and materials for anabolism, is observed in a wide range of tumor cells, making it a potential pathway to control cancer growth. ALDOA is a multifunctional enzyme in the glycolytic pathway and
Emily R Billinge et al.
Biosensors & bioelectronics, 68, 741-748 (2015-02-16)
Diagnostics that are capable of detecting multiple biomarkers are improving the accuracy and efficiency of bioassays. In previous work we have demonstrated the potential of an aptamer-based sensor (aptasensor) utilising Tunable Resistive Pulse Sensing (TRPS). Here, we have advanced the
Ping Ye et al.
BMC cell biology, 10, 2-2 (2009-01-14)
Control of intercellular penetration of microbial products is critical for the barrier function of oral epithelia. We demonstrated that CD24 is selectively and strongly expressed in the cells of the epithelial attachment to the tooth and the epithelial lining of
Debdatto Mookherjee et al.
Autophagy, 17(7), 1729-1752 (2020-06-20)
Turnover of cellular organelles, including endoplasmic reticulum (ER) and mitochondria, is orchestrated by an efficient cellular surveillance system. We have identified a mechanism for dual regulation of ER and mitochondria under stress. It is known that AMFR, an ER E3
Nittaya Khakhum et al.
NPJ vaccines, 6(1), 72-72 (2021-05-15)
Melioidosis, caused by Burkholderia pseudomallei (Bpm), lacks a vaccine. We identify the immune correlates of protection induced by B. mallei ΔtonB Δhcp1 (CLH001) and Bpm ΔtonB Δhcp1 (PBK001) vaccines against inhalational melioidosis. Mucosal immunization with either vaccine generates Bpm-specific IgM
V van Duinen et al.
Angiogenesis, 22(1), 157-165 (2018-09-02)
Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is orchestrated by cues from within the cellular microenvironment, such as biochemical gradients and perfusion. However, many of these cues are missing in current in vitro models of angiogenic
Stefan Becker et al.
Bio-protocol, 8(8), e2666-e2666 (2018-04-20)
The marine beta-glucan laminarin is an abundant storage polysaccharide in microalgae. High production rates and rapid digestion by heterotrophic bacteria turn laminarin into an ideal carbon and energy source, and it is therefore a key player in the marine carbon
Lorcan P Browne et al.
Cell reports, 41(10), 111750-111750 (2022-12-09)
Successful neuronal regeneration requires the reestablishment of synaptic connectivity. This process requires the reconstitution of presynaptic neurotransmitter release, which we investigate here in a model of entirely natural regeneration. After toxin-induced injury, olfactory sensory neurons in the adult mouse olfactory
Yang Zhang et al.
Cell metabolism, 33(1), 94-109 (2020-11-08)
The emergence of cancer from diverse normal tissues has long been rationalized to represent a common set of fundamental processes. However, these processes are not fully defined. Here, we show that forced expression of glucose-6-phosphate dehydrogenase (G6PD) affords immortalized mouse
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