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Y B Shaik-Dasthagirisaheb et al.
Journal of biological regulators and homeostatic agents, 27(2), 291-295 (2013-07-09)
Inflammatory responses are operationally characterized by pain, redness, heat and swelling at the site of infection and trauma. Mast cells reside near small blood vessels and, when activated, release potent mediators involved in allergy and inflammation. Vitamin D modulates contraction
Effect of an extruded pea or rice diet on postprandial insulin and cardiovascular responses in dogs.
J L Adolphe et al.
Journal of animal physiology and animal nutrition, 99(4), 767-776 (2014-12-06)
Peas are increasing in popularity as a source of carbohydrate, protein and fibre in extruded canine diets. The aim of this study was to test the health effects of two canine diets with identical macronutrient profiles, but containing either yellow
C Li et al.
Journal of dental research, 94(3), 455-463 (2015-01-15)
Recent studies have demonstrated that erythropoietin (EPO) has extensive nonhematopoietic biological functions. However, little is known about how EPO regulates bone formation, although several studies suggested that EPO can affect bone homeostasis. In this study, we investigated the effects of
Jae Hyeon Kim et al.
Oncology reports, 34(1), 221-226 (2015-05-23)
Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell
Prasuna Paluru et al.
Stem cell research, 12(2), 441-451 (2014-01-15)
The Wnt gene family consists of structurally related genes encoding secreted signaling molecules that have been implicated in many developmental processes, including regulation of cell fate and patterning during embryogenesis. Previously, we found that Wnt signaling is required for primitive
Jan Simon Boerma et al.
Chemico-biological interactions, 207, 32-40 (2013-11-20)
Reactive metabolites have been suggested to play a role in the idiosyncratic hepatotoxicity observed with diclofenac (DF). By structural identification of the GSH conjugates formed after P450-catalyzed bioactivation of DF, it was shown that three types of reactive intermediates were
Adil Sattar et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 70(9), 782-786 (2013-04-18)
A potential interaction involving therapeutic doses of ascorbic acid and warfarin is described. A 65-year-old Caucasian man with chronic cardiac and pulmonary disorders was admitted to the emergency room for chest pain, shortness of breath, nausea, and diaphoresis. Imaging scans
Bharathinagar S Suresha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(9), 849-859 (2014-06-12)
Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nigerloxin, a fungal metabolite and a potent aldose reductase inhibitor and free radical
M Pohanka et al.
Mini reviews in medicinal chemistry, 12(1), 35-43 (2011-11-11)
Ascorbic acid is a low molecular weight antioxidant well known as anti-scorbut acting vitamin C in humans, primates and guinea pigs. This review summarizes basic data about ascorbic acid in its physiological action point of view. It is divided into
Ahmad Salti et al.
Cells, 10(8) (2021-08-28)
Mitochondria play a key role in metabolic transitions involved in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), but the underlying molecular mechanisms remain largely unexplored. To obtain new insight into the mechanisms of cellular reprogramming, we
Katherine A Glass et al.
Biomaterials, 35(22), 5921-5931 (2014-04-29)
The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to
M Sato et al.
Oral diseases, 21(1), e86-e97 (2014-03-13)
Mesiodentes are usually found in the central position of the upper or lower jaw as supernumerary teeth. Here, we obtained 10 mesiodentes and three permanent teeth (PT) and separated the dental pulp (DP) from these into crown and root portions.
Min Zhou et al.
Acta pharmacologica Sinica, 36(11), 1388-1394 (2015-10-27)
S100A4, also known as fibroblast-specific protein 1 or metastasin 1, is not only highly expressed in growth-stimulated cultured cells and metastatic tumor cells, but also in the periodontal ligament. The aim of this study was to investigate the roles of
Wei Liu et al.
Journal of materials science. Materials in medicine, 26(7), 203-203 (2015-07-15)
The β-titanium alloy is thought to be a promising alloy using as orthopedic or dental implants owing to its characteristics, which contains low elastic modulus, high corrosion resistance and well biocompatibility. Our previous study has reported that a new β-titanium
Xiaoping Su et al.
Cancer research, 75(14), 2875-2885 (2015-06-13)
microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of the interaction complexity and the
S Antonini et al.
Biomedical materials (Bristol, England), 10(3), 035010-035010 (2015-06-25)
Through the interaction with topographical features, endothelial cells tune their ability to populate target substrates, both in vivo and in vitro. Basal textures interfere with the establishment and maturation of focal adhesions (FAs) thus inducing specific cell-polarization patterns and regulating
Stacey C Schutte et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 308-315 (2014-07-18)
Endometrial stromal and epithelial cell cross talk is known to influence many of the dynamic changes that occur during the menstrual cycle. We modified our previous model and embedded telomerase-immortalized human endometrial stromal cells and Ishikawa adenocarcinoma epithelial cells in
Huey-Chun Huang et al.
International journal of molecular sciences, 16(5), 10470-10490 (2015-05-12)
The effects of essential oil from Eucalyptus camaldulensis flowers oil on melanogenesis and the oil's antioxidant characteristics were investigated. Assays of mushroom and cellular tyrosinase activities and melanin content of mouse melanoma cells were performed spectrophotometrically, and the expression of
Kalaiselvi Senthil et al.
PloS one, 10(4), e0123360-e0123360 (2015-04-16)
Free radical scavenging activity (FRSA), total phenolic content (TPC), and total flavonoid content (TFC) of in vitro cultured and field grown Withania somnifera (Ashwagandha) roots were investigated. Withanolides analysis and comprehensive metabolic profiling between 100% methanol extracts of in vitro
Xinjie Cai et al.
Journal of clinical periodontology, 42(4), 380-389 (2015-02-19)
The implantation of bone marrow-derived mesenchymal stem cells (MSCs) has previously been shown successful to achieve periodontal regeneration. However, the preferred pre-implantation differentiation strategy (e.g. maintenance of stemness, osteogenic or chondrogenic induction) to obtain optimal periodontal regeneration is still unknown.
D D Simon et al.
Cells, tissues, organs, 200(2), 104-117 (2015-05-01)
Cell-populated collagen gels have provided significant insight into the cellular contractile mechanisms and cell-matrix interactions that are necessary for compacting and remodeling extant matrix. Nevertheless, little research has been devoted towards determining how cells entrench these deformations that contribute to
Marina Barandun et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1111-1119 (2015-05-23)
We investigated whether nasal chondrocytes (NC) can be used to generate composite constructs with properties necessary for the repair of osteochondral (OC) lesions, namely maturation, integration and capacity to recover from inflammatory burst. OC grafts were fabricated by combining engineered
G J Molderings et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1523-1534 (2014-05-08)
In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as
S Natesan et al.
Translational psychiatry, 4, e376-e376 (2014-04-03)
A number of phosphodiesterase 10A (PDE10) inhibitors are about to undergo clinical evaluation for their efficacy in treating schizophrenia. As phosphodiesterases are in the same signalling pathway as dopamine D2 receptors, it is possible that prior antipsychotic treatment could influence
Kar-Lok Wong et al.
Pharmacological reports : PR, 66(6), 1106-1113 (2014-12-03)
Astrocytes do not only maintain homeostasis of the extracellular milieu of the neurons, but also play an active role in modulating synaptic transmission. Palmitic acid (PA) is a saturated fatty acid which, when being excessive, is a significant risk factor
Ilaria Colzi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 411-418 (2015-06-29)
To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a
Yong-Jin Chen et al.
Cell and tissue research, 361(2), 439-455 (2015-03-24)
Our aim is to investigate the cytobiological effects of autologous platelet-rich fibrin (PRF) on dental pulp stem cells (DPSCs) and to explore the ectopic and orthotopic possibilities of dental pulp revascularization and pulp-dentin complex regeneration along the root canal cavities
Faten Shaeib et al.
PloS one, 10(3), e0120737-e0120737 (2015-04-04)
Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron. Here we show that the presence of melatonin (MLT) can prevent HOCl-mediated
Shogo Sasaki et al.
Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)
We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of
Changhao Fu et al.
Cell biology international, 39(7), 777-787 (2015-06-19)
We isolated human embryonic cartilage stem cells (hECSCs), a novel stem cell population, from the articular cartilage of eight-week-old human embryos. These stem cells demonstrated a marker expression pattern and differentiation potential intermediate to those of human embryonic stem cells
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