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关键词:'A4403'
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Harmeet S Sandhu et al.
Bioorganic & medicinal chemistry, 18(15), 5626-5633 (2010-07-14)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (epsilon), donor number (DN), acceptor number (AN)
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and
SuJung Hu et al.
Food chemistry, 194, 1089-1094 (2015-10-17)
The antioxidant capacity and attributable bioactive compounds of puffed cacao beans were investigated. Roasting was carried out at 190°C for 15min and puffing was performed at 4-7kgf/cm(2). Cacao beans puffed at 4kgf/cm(2) showed the highest total polyphenols (23.16mgGAE/gsample) and total
S Cyboran et al.
Life sciences, 126, 1-9 (2015-02-24)
This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. The extract's activity was evaluated on the basis of its hemolytic, antioxidant
Sawsan Aboul-Fotouh
Psychopharmacology, 232(6), 1095-1105 (2014-10-16)
Several studies have pointed to the nicotinic acetylcholine receptor (nAChR) antagonists, such as mecamylamine (MEC), as a potential therapeutic target for the treatment of depression. The present study evaluated the behavioral and neurochemical effects of chronic administration of MEC (1
Tsung-Hsun Hsieh et al.
Cerebral cortex (New York, N.Y. : 1991), 25(7), 1806-1814 (2014-01-24)
Repetitive magnetic stimulation (rTMS), including theta burst stimulation (TBS), is capable of modulating motor cortical excitability through plasticity-like mechanisms and might have therapeutic potential for Parkinson's disease (PD). An animal model would be helpful for elucidating the mechanism of rTMS
Stephen Flowers et al.
Bone, 69, 47-54 (2014-09-04)
The retinoblastoma protein family is intimately involved in the regulation of tissue specific gene expression during mesenchymal stem cell differentiation. The role of the following proteins, pRB, p107 and p130, is particularly significant in differentiation to the osteoblast lineage, as
Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in
Phil Jun Kang et al.
Biomaterials, 35(26), 7336-7345 (2014-06-03)
Somatic cells can be reprogrammed to generate induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc. However, exogenous expression of pluripotency factors raised concerns for clinical applications. Here, we show that iPS-like cells
Chiara Marioli et al.
International journal of molecular sciences, 21(19) (2020-10-11)
Mitochondrial dysfunction is a key element in the pathogenesis of neurodegenerative disorders, such as riboflavin transporter deficiency (RTD). This is a rare, childhood-onset disease characterized by motoneuron degeneration and caused by mutations in SLC52A2 and SLC52A3, encoding riboflavin (RF) transporters
E D N S Abeyrathne et al.
Poultry science, 94(9), 2280-2287 (2015-07-22)
Ovomucoid is well known as a "trypsin inhibitor" and is considered to be the main food allergen in egg. However, the negative functions of ovomucoid can be eliminated if the protein is cut into small peptides. The objectives of this
Delwen L Franzen et al.
Journal of neurophysiology, 113(2), 524-536 (2014-10-31)
Passive and active membrane properties determine the voltage responses of neurons. Within the auditory brain stem, refinements in these intrinsic properties during late postnatal development usually generate short integration times and precise action-potential generation. This developmentally acquired temporal precision is
Judith Bleuel et al.
Journal of biomechanical engineering, 137(6), 061009-061009 (2015-03-18)
Mechanical loading influences the structural and mechanical properties of articular cartilage. The cartilage matrix protein collagen II essentially determines the tensile properties of the tissue and is adapted in response to loading. The collagen II network is stabilized by the
Ibironke O Olofin et al.
Journal of acquired immune deficiency syndromes (1999), 67 Suppl 4, S173-S178 (2014-12-02)
HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age. HIV-infected pregnant
Jonathan Sagal et al.
Stem cells translational medicine, 3(8), 888-898 (2014-06-07)
Human pluripotent stem cells (PSCs) are a promising cell resource for various applications in regenerative medicine. Highly efficient approaches that differentiate human PSCs into functional lineage-specific neurons are critical for modeling neurological disorders and testing potential therapies. Proneural transcription factors
Tingting Zhang et al.
Cell reports, 35(10), 109208-109208 (2021-06-10)
Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors
Christin Striegler et al.
Macromolecular bioscience, 15(9), 1283-1295 (2015-05-29)
Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex
Mohammad Fazel et al.
Materials science & engineering. C, Materials for biological applications, 120, 111745-111745 (2021-02-07)
The recently developed additively manufacturing techniques have enabled the fabrication of porous biomaterials that mimic the characteristics of the native bone, thereby avoiding stress shielding and facilitating bony ingrowth. However, aseptic loosening and bacterial infection, as the leading causes of
Chao Ma et al.
Journal of natural products, 68(8), 1259-1261 (2005-08-30)
Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, chrysoeriol 4'-O-beta-D-glucopyranoside (2), chrysoeriol 7-O-beta-D-glucopyranoside (3), alternanthin (4), and daucosterol. The structure of 1 was established on
Quan Zhou et al.
Journal of cellular and molecular medicine, 19(3), 521-534 (2014-10-30)
Spermatogonial stem cells (SSCs) are undifferentiated cells that are required to maintain spermatogenesis throughout the reproductive life of mammals. Although SSC transplantation and culture provide a powerful tool to identify the mechanisms regulating SSC function, the precise signalling mechanisms governing
Axel Teichert et al.
Journal of natural products, 71(6), 1092-1094 (2008-05-02)
Chemical analysis of the fruiting bodies of the agaricoid fungus Cortinarius subtortus yielded three new natural products, two quinoline and one isocarbostyryl alkaloid. The structures of compounds 1- 3 were determined by analysis of NMR and MS data. Compound 1
H Li et al.
Cell death and differentiation, 22(12), 1935-1945 (2015-07-25)
Osteoporosis is a disease marked by reduced bone mass, leading to an increased risk of fractures or broken bones. Bone formation is mediated by recruiting mesenchymal stem cells (MSCs). Elucidation of the molecular mechanisms that regulate MSC differentiation into osteoblasts
Wan Mohd Nuzul Hakimi Wan Salleh et al.
Natural product communications, 10(7), 1297-1300 (2015-09-29)
This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in the essential oils, which made up 86.8% and 89.7%
Srikanth Pedireddy et al.
Nature communications, 5, 4947-4947 (2014-09-18)
Nanoporous gold with networks of interconnected ligaments and highly porous structure holds stimulating technological implications in fuel cell catalysis. Current syntheses of nanoporous gold mainly revolve around de-alloying approaches that are generally limited by stringent and harsh multistep protocols. Here
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Chia-Hui Chuang et al.
Acta biomaterialia, 19, 85-99 (2015-03-10)
To manufacture tissue engineering-based functional tissues, scaffold materials that can be sufficiently vascularized to mimic the functionality and complexity of native tissues are needed. Currently, vascular network bioengineering is largely carried out using natural hydrogels as embedding scaffolds, but most
Pietro Squillace et al.
Food chemistry, 315, 126224-126224 (2020-02-03)
This work considered lycopene (lyc) amount and (all-E)-lyc:Z-lyc (E:Z) ratio as driving parameters of the tomato pomace (TP) supercritical CO2 extraction (SFE_CO2) performance. By testing lyc concentrations solubilization in tomato seed oil and E:Z ratios of 75:25, 59:39 and 25:75
Wei-Fang Chang et al.
International journal of molecular sciences, 20(5) (2019-03-16)
Mammalian telomere lengths are primarily regulated by telomerase, consisting of a reverse transcriptase protein (TERT) and an RNA subunit (TERC). We previously reported the generation of mouse Terc+/- and Terc-/- embryonic stem cells (ntESCs) by somatic cell nuclear transfer. In
Julian M Carosi et al.
Autophagy, 17(9), 2217-2237 (2020-09-23)
The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders including Alzheimer disease. Spatial
Martin Müller et al.
Scientific reports, 5, 11742-11742 (2015-07-08)
The protein kinase D isoenzymes PKD1/2/3 are prominent downstream targets of PKCs (Protein Kinase Cs) and phospholipase D in various biological systems. Recently, we identified PKD isoforms as novel mediators of tumour cell-endothelial cell communication, tumour cell motility and metastasis.
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