CN
Search Within
A6419
应用筛选条件
关键词:'A6419'
显示 31-60 共 68 条结果 关于 "A6419" 范围 论文
Crosstalk between purinergic receptors and canonical signaling pathways in the mouse salivary gland.
Sumit Bhattacharya et al.
Cell calcium, 58(6), 589-597 (2015-10-08)
Isolated clusters of mouse parotid acinar cells in combination with live cell imaging were used to explore the crosstalk in molecular signaling between purinergic, cholinergic and adrenergic pathways that integrate to control fluid and protein secretion. This crosstalk was manifested
Ran Zheng et al.
Journal of inflammation research, 14, 3063-3075 (2021-07-17)
Inflammasome-induced neuroinflammation is a key contributor to the pathology of Parkinson's disease (PD). NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation has been implicated in PD in postmortem human PD brains, indicating it as a potential target for PD treatment.
Veronica Jové et al.
Neuron, 108(6), 1163-1180 (2020-10-14)
Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal
Rui Xiong et al.
Toxicology and applied pharmacology, 280(2), 285-295 (2014-08-26)
Para-quinones such as 1,4-Benzoquinone (BQ) and menadione (MD) and ortho-quinones including the oxidation products of catecholamines, are derived from xenobiotics as well as endogenous molecules. The effects of quinones on major protein handling systems in cells; the 20/26S proteasome, the
Nipun S Basrur et al.
eLife, 9 (2020-12-08)
The Aedesaegypti mosquito shows extreme sexual dimorphism in feeding. Only females are attracted to and obtain a blood-meal from humans, which they use to stimulate egg production. The fruitless gene is sex-specifically spliced and encodes a BTB zinc-finger transcription factor
In Young Lee et al.
Molecular cell, 73(6), 1138-1149 (2019-03-23)
The nuclear factor (NF)-κB pathway plays a central role in inflammatory and immune responses, with aberrant activation of NF-κB signaling being implicated in various human disorders. Here, we show that mammalian ste20-like kinase 1 (MST1) is a previously unrecognized component
Ambre M Bertholet et al.
Nature, 571(7766), 515-520 (2019-07-26)
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been proposed that AAC mediates mitochondrial uncoupling, but
Nilisha Fernando et al.
Frontiers in cell and developmental biology, 8, 516-516 (2020-07-17)
MicroRNAs (miRNAs) are small, non-coding RNA molecules that have powerful regulatory properties, with the ability to regulate multiple messenger RNAs (mRNAs) and biological pathways. MicroRNA-223-3p (miR-223) is known to be a critical regulator of the innate immune response, and its
Yuanling Huang et al.
Journal of cellular physiology, 234(11), 21224-21234 (2019-04-30)
Cannabidiol (CBD), an abundant nonpsychoactive constituent of marijuana, has been reported previously to protect against hepatic steatosis. In this study, we studied further the functions and mechanisms of CBD on liver inflammation induced by HFC diet. Mice feeding an HFC
Extracellular ATP and adenosine: the Yin and Yang in immune responses?
Faas MM, et al.
Molecular Aspects of Medicine, 55(5), 9-19 (2017)
Tetsuya Handa et al.
Nature protocols, 15(10), 3334-3360 (2020-08-19)
Cell identity is determined by the selective activation or silencing of specific genes via transcription factor binding and epigenetic modifications on the genome. Chromatin immunoprecipitation (ChIP) has been the standard technique for mapping the sites of transcription factor binding and
Brent Asrican et al.
STAR protocols, 2(1), 100335-100335 (2021-02-23)
The transition from quiescence to activation in radial neural stem cells (rNSCs) is a key first step in the process of adult neurogenesis, which can be monitored in the context of circuit activation in live tissue by whole-cell patch-clamp recording
Weerachat Sompong et al.
PloS one, 10(6), e0129495-e0129495 (2015-06-09)
Ferulic acid (FA) is the ubiquitous phytochemical phenolic derivative of cinnamic acid. Experimental studies in diabetic models demonstrate that FA possesses multiple mechanisms of action associated with anti-hyperglycemic activity. The mechanism by which FA prevents diabetes-associated vascular damages remains unknown.
Qiong-Zhen Zeng et al.
Frontiers in immunology, 10, 72-72 (2019-02-15)
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in
Lizhen Qiao et al.
Journal of chromatography. A, 1360, 240-247 (2014-08-19)
Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In
Ajay Dixit et al.
American journal of physiology. Gastrointestinal and liver physiology, 317(4), G463-G475 (2019-08-23)
In the current study, we explored the role of extracellular ATP (eATP) in promoting systemic inflammation during development of acute pancreatitis (AP). Release of extracellular (e)ATP was evaluated in plasma and bronchoalveolar lavage fluid (BALF) of mice with experimental acute
Nora Grahl et al.
PLoS pathogens, 11(8), e1005133-e1005133 (2015-09-01)
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
de la Roche M, et al.
The Journal of Cell Biology, 217(10), 3560-3576 (2018)
Moumita Basu et al.
Journal of cell science, 133(7) (2020-02-23)
Intracellular survival of Leishmania donovani demands rapid production of host ATP for its sustenance. However, a gradual decrease in intracellular ATP in spite of increased glycolysis suggests ATP efflux during infection. Accordingly, upon infection, we show here that ATP is
Hoseok Choi et al.
Biosensors & bioelectronics, 73, 93-99 (2015-06-09)
We report a simple method for analyzing sequential phosphorylation by protein kinases using fluorescent peptide substrates and microfluidic isoelectric focusing (μIEF) electrophoresis. When a dye-labeled peptide substrate was sequentially phosphorylated by two consecutive protein kinases (mitogen-activated protein kinase (MAPK) and
Alessandra Pecorelli et al.
Redox biology, 28, 101334-101334 (2019-10-14)
Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by mutations in the X-linked MECP2 gene. RTT patients show multisystem disturbances associated with an oxinflammatory status. Inflammasomes are multi-protein complexes, responsible for host immune responses against pathogen infections and
Xi-Lan Tang et al.
Inflammation, 38(1), 94-101 (2014-09-06)
Inflammatory response is an important mechanism in the pathogenesis of cardiovascular diseases. Cardiac fibroblasts play a crucial role in cardiac inflammation and might become a potential therapeutic target in cardiovascular diseases. Kaempferol, a flavonoid commonly existing in many edible fruits
Changliang He et al.
International immunopharmacology, 71, 328-335 (2019-04-06)
Pyroptosis is a different type of proinflammatory and lytic mode of cell death from apoptosis and necrosis, which play a killer and cleaner to the pathogenic microorganisms as an immune response when the host is infected by pathogenic microorganisms. Ketone
Yvette Wooff et al.
Scientific reports, 10(1), 2263-2263 (2020-02-12)
Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches
Albert Shim et al.
Bio-protocol, 7(7), e2210-e2210 (2017-04-05)
The purpose of this protocol is to provide an updated method of performing microtubule gliding assays and visualizing it using fluorescence microscopy.
Rudolf Pisa et al.
Cell chemical biology, 27(7), 850-857 (2020-05-23)
Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance-a major factor limiting the long-term efficacy of molecularly targeted therapeutics. However, for most anticancer drugs we lack analyses of drug-resistance mechanisms in cells with
Rui Xiong et al.
Molecular pharmacology, 88(6), 1045-1054 (2015-09-26)
A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is protein misfolding and aggregation that in turn leads to neurotoxicity. Targeting Hsp90 is an attractive strategy to halt neurodegenerative diseases, and benzoquinone ansamycin (BQA) Hsp90 inhibitors such as geldanamycin
Kajal Hamidzadeh et al.
Blood advances, 4(21), 5460-5472 (2020-11-10)
Stimulated macrophages are potent producers of inflammatory mediators. This activity is highly regulated, in part, by resolving molecules to prevent tissue damage. In this study, we demonstrate that inflammation induced by Toll-like receptor stimulation is followed by the upregulation of
Monika Bambouskova et al.
Cell reports, 34(10), 108756-108756 (2021-03-11)
Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is
Conditional knockdown of proteins using auxin-inducible degron (AID) fusions in Toxoplasma gondii
Brown KM, et al.
Bio-protocol, 8(4), 245-253 (2018)
2/3