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Kajal Hamidzadeh et al.
Blood advances, 4(21), 5460-5472 (2020-11-10)
Stimulated macrophages are potent producers of inflammatory mediators. This activity is highly regulated, in part, by resolving molecules to prevent tissue damage. In this study, we demonstrate that inflammation induced by Toll-like receptor stimulation is followed by the upregulation of
Yvette Wooff et al.
Scientific reports, 10(1), 2263-2263 (2020-02-12)
Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches
Xi-Lan Tang et al.
Inflammation, 38(1), 94-101 (2014-09-06)
Inflammatory response is an important mechanism in the pathogenesis of cardiovascular diseases. Cardiac fibroblasts play a crucial role in cardiac inflammation and might become a potential therapeutic target in cardiovascular diseases. Kaempferol, a flavonoid commonly existing in many edible fruits
Changliang He et al.
International immunopharmacology, 71, 328-335 (2019-04-06)
Pyroptosis is a different type of proinflammatory and lytic mode of cell death from apoptosis and necrosis, which play a killer and cleaner to the pathogenic microorganisms as an immune response when the host is infected by pathogenic microorganisms. Ketone
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
de la Roche M, et al.
The Journal of Cell Biology, 217(10), 3560-3576 (2018)
Nora Grahl et al.
PLoS pathogens, 11(8), e1005133-e1005133 (2015-09-01)
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The
Rui Xiong et al.
Molecular pharmacology, 88(6), 1045-1054 (2015-09-26)
A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is protein misfolding and aggregation that in turn leads to neurotoxicity. Targeting Hsp90 is an attractive strategy to halt neurodegenerative diseases, and benzoquinone ansamycin (BQA) Hsp90 inhibitors such as geldanamycin
Albert Shim et al.
Bio-protocol, 7(7), e2210-e2210 (2017-04-05)
The purpose of this protocol is to provide an updated method of performing microtubule gliding assays and visualizing it using fluorescence microscopy.
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