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Michaela Liegertová et al.
Scientific reports, 5, 11885-11885 (2015-07-15)
Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here
Yiqun Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(48), 14966-14971 (2015-12-03)
Mammals detect and discriminate numerous odors via a large family of G protein-coupled odorant receptors (ORs). However, little is known about the molecular and structural basis underlying OR response properties. Using site-directed mutagenesis and computational modeling, we studied ORs sharing
Dustin Shilling et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 6910-6923 (2014-05-16)
Exaggerated intracellular Ca(2+) signaling is a robust proximal phenotype observed in cells expressing familial Alzheimer's disease (FAD)-causing mutant presenilins (PSs). The mechanisms that underlie this phenotype are controversial and their in vivo relevance for AD pathogenesis is unknown. Here, we
Seong-Il Kang et al.
Biological & pharmaceutical bulletin, 38(4), 552-558 (2015-03-05)
Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did
Etti Ben-Shushan et al.
Stem cells (Dayton, Ohio), 33(2), 403-415 (2014-10-23)
In the pMN domain of the spinal cord, Notch signaling regulates the balance between motor neuron differentiation and maintenance of the progenitor state for later oligodendrocyte differentiation. Here, we sought to study the role of Notch signaling in regulation of
Yu-Jen Chang et al.
Stem cells and development, 24(15), 1740-1750 (2015-04-30)
Human neural stem cells (NSCs) are particularly valuable for the study of neurogenesis process and have a therapeutic potential in treating neurodegenerative disorders. However, current progress in the use of human NSCs is limited due to the available NSC sources
Rui-Song Ye et al.
PloS one, 10(7), e0131987-e0131987 (2015-07-03)
The anterior pituitary is the most important endocrine organ modulating animal postnatal growth, mainly by controlling growth hormone (GH) gene transcription, synthesis, and secretion. As an ideal model for animal postnatal growth studies, the Bama minipig is characterized as having
Elisabetta Albi et al.
PloS one, 9(5), e98250-e98250 (2014-05-29)
Maintaining a good health requires the maintenance of a body homeostasis which largely depends on correct functioning of thyroid gland. The cells of the thyroid tissue are strongly sensitive to hypogravity, as already proven in mice after returning to the
Debolina Ray et al.
The American journal of pathology, 185(4), 1061-1072 (2015-03-22)
During cholestatic liver disease, there is dysregulation in the balance between biliary growth and loss in bile duct-ligated (BDL) rats modulated by neuroendocrine peptides via autocrine/paracrine pathways. Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and
Floriana Volpicelli et al.
PloS one, 9(10), e109671-e109671 (2014-10-29)
Estrogens promote a plethora of effects in the CNS that profoundly affect both its development and mature functions and are able to influence proliferation, differentiation, survival and neurotransmission. The biological effects of estrogens are cell-context specific and also depend on
Lei Tian et al.
Scientific reports, 5, 16117-16117 (2015-11-04)
This study mainly investigated the neurotoxicity induced by zinc oxide nanoparticle (ZnO NP) in different-aged mice and the interaction between age and ZnO NP exposure. Sixty adult and old male C57BL/6J mice were assigned to four groups based on a
Tsugunobu Andoh et al.
Journal of dermatological science, 76(3), 206-213 (2014-12-03)
Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is the main symptom of dermatitides, such as atopic dermatitis, and is very difficult to
Chunxia Cao et al.
Journal of the National Cancer Institute, 107(1), 358-358 (2014-12-04)
Cyclooxygenase-2 (COX-2) directs the synthesis of prostaglandins including PGE-2 linking inflammation with mitogenic signaling. COX-2 is also an anticancer target, however, treatment strategies have been limited by unreliable expression assays and by inconsistent tumor responses to COX-2 inhibition. We analyzed
Christian D Laourdakis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 127-133 (2014-08-05)
Targeted metabolite profiling has aided in the understanding of a variety of biological processes in the malaria parasite as well as in drug discovery. A fast and sensitive analytical method, based on ion-pairing reversed phase ultra-high performance liquid chromatography tandem
Jung Eun Choi et al.
Oncology reports, 33(3), 1395-1401 (2015-01-17)
ABT-737, a BH3-mimetic small-molecule inhibitor, binds with very high affinity to Bcl-2, Bcl-xL and Bcl-w, and inhibits their activity. Aurora kinase is one of the serine/threonine kinase family members and is a vital and critical regulator of mitosis and meiosis.
Lindsey C Morris et al.
Journal of biomolecular screening, 19(6), 847-858 (2014-02-15)
Injectable, degradation-resistant peptide agonists for the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R), such as exenatide and liraglutide, activate the GLP-1R via a complex orthosteric-binding site and are effective therapeutics for glycemic control in type 2 diabetes. Orally bioavailable orthosteric small-molecule
Linjie Chen et al.
Biochemistry, 53(17), 2827-2839 (2014-04-15)
The pineal gland hormone melatonin exerts its regulatory roles in a variety of physiological and pathological responses through two G protein-coupled receptors, melatonin receptor type 1 (MT1) and melatonin receptor type 2 (MT2), which have been recognized as promising targets
C K Daniels et al.
Journal of pharmacological and toxicological methods, 31(1), 41-46 (1994-02-01)
A solid-phase radioimmunoassay for cAMP in tissues, body fluids, and cultured cells has been developed using 125I-2'-O-monosuccinyl adenosine-3':5'-cyclic monophosphate tyrosyl methyl ester and High Binding EIA microtiter strips coated overnight at 4 degrees C with a rabbit or sheep polyclonal
Stephanie M Amato et al.
Molecular cell, 50(4), 475-487 (2013-05-15)
Bacterial persisters are phenotypic variants that form from the action of stress response pathways triggering toxin-mediated antibiotic tolerance. Although persisters form during normal growth from native stresses, the pathways responsible for this phenomenon remain elusive. Here we have discovered that
Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology.
Julie Dufresne et al.
Current protocols, 4(1), e975-e975 (2024-01-29)
Spermatozoa are formed in the testis but must transit through the epididymis to acquire motility and the ability to fertilize. The epididymis is a single convoluted tubule comprising several anatomically and physiologically distinct regions. The pseudostratified epithelium consists of multiple
Masahiro Myojo et al.
PloS one, 9(5), e96948-e96948 (2014-05-16)
Because endothelial nitric oxide synthase (eNOS) has anti-inflammatory and anti-arteriosclerotic functions, it has been recognized as one of the key molecules essential for the homeostatic control of blood vessels other than relaxation of vascular tone. Here, we examined whether telmisartan
Justyna Kusek et al.
Molecular pharmacology, 87(1), 39-51 (2014-10-31)
Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-adenosine receptor as a sensor to explore
Cécile Coste et al.
PloS one, 12(7), e0177962-e0177962 (2017-07-07)
Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC.
Ahmed E Goda et al.
Molecular oncology, 9(1), 309-322 (2014-09-24)
Novel combinations aiming at maximizing the efficacy of bortezomib are highly valued in the clinic. Therefore the current study investigated the outcomes of combining bortezomib with dipyridamole, a well-known antiplatelet. The co-treatment exerted a synergistic lethality in a panel of
CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK.
Yanyan Ma et al.
Cell death & disease, 15(2), 121-121 (2024-02-09)
Mutation in CUL4B gene is one of the most common causes for X-linked intellectual disability (XLID). CUL4B is the scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B) complex. While the roles of CUL4B in cancer progression and some developmental processes like
Belinda J Nixon et al.
PloS one, 9(5), e94904-e94904 (2014-05-03)
Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been associated with impaired
A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.
Cong Xu et al.
Cell, 155(4), 909-921 (2013-11-12)
Ex vivo expansion of satellite cells and directed differentiation of pluripotent cells to mature skeletal muscle have proved difficult challenges for regenerative biology. Using a zebrafish embryo culture system with reporters of early and late skeletal muscle differentiation, we examined
Frédéric J J Bihel et al.
Bioorganic & medicinal chemistry letters, 21(21), 6567-6572 (2011-09-17)
Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of micro- to sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4-benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.
Sasuk Kim et al.
Experimental neurology, 252, 63-74 (2013-11-21)
Parkinson's disease (PD) is clinically characterized not only by motor symptoms but also by non-motor symptoms, such as anxiety and mood changes. Based on our previous study showing that overexpression of wild-type or mutant α-synuclein (α-SYN) interferes with cAMP/PKA-dependent transcriptional
Hanieh Bagheri Tudashki et al.
Molecular pharmacology, 85(1), 148-161 (2013-11-01)
Traditional assays that monitor cAMP inhibition by opioid receptor ligands require second-messenger accumulation over periods of 10-20 minutes. Since receptor regulation occurs within a similar time frame, such assays do not discriminate the actual signal from its modulation. Here we
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