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Michaela Liegertová et al.
Scientific reports, 5, 11885-11885 (2015-07-15)
Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here
Soheil S Dadras et al.
The American journal of pathology, 185(1), 252-265 (2014-12-03)
Microphthalmia-associated transcription factor (MITF) acts via pigment epithelium-derived factor (PEDF), an antiangiogenic protein, to regulate retinal pigment epithelium migration. PEDF expression and/or regulation during melanoma development have not been investigated previously. Using immunohistochemistry, we determined expression of PEDF in common
Erkan Kiris et al.
Neurotoxicity research, 27(4), 384-398 (2015-03-19)
Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation
Erica Sarchielli et al.
Experimental neurology, 257, 130-147 (2014-05-06)
Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the
A Lerche et al.
Acta neurologica Scandinavica, 69(3), 168-175 (1984-03-01)
Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) were measured in cerebrospinal fluid (CSF) and plasma from 7 patients with bacterial meningitis, 9 patients with serous meningitis, 5 patients with idiopathic polyneuritis and 15 reference patients. A significantly (P
Yusuke Kumai et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(1), R51-R60 (2013-11-22)
In the current study, the role of cAMP in stimulating Na(+) uptake in larval zebrafish was investigated. Treating larvae at 4 days postfertilization (dpf) with 10 μM forskolin or 1 μM 8-bromo cAMP significantly increased Na(+) uptake by three-fold and
Shuang Yang et al.
Die Pharmazie, 68(9), 772-776 (2013-10-24)
The naturally occurring polyphenol compound resveratrol (RES) has been receiving wide attention because of its variety of health benefits and favourable biological activities. Previous studies have shown that RES could induce intestinal chloride secretion in mouse jejunum and stimulate cAMP-dependent
Elisabetta Albi et al.
PloS one, 9(5), e98250-e98250 (2014-05-29)
Maintaining a good health requires the maintenance of a body homeostasis which largely depends on correct functioning of thyroid gland. The cells of the thyroid tissue are strongly sensitive to hypogravity, as already proven in mice after returning to the
Peter Molnar et al.
Journal of cell communication and signaling, 8(1), 29-37 (2013-12-12)
The cAMP response element-binding protein (CREB) is a transcription factor that mediates the cellular response to metabolic and mitogenic signals. Whether CREB contributes to vascular function has received little attention, especially in relation to the processes associated with atherosclerotic disease
Yu-Jen Chang et al.
Stem cells and development, 24(15), 1740-1750 (2015-04-30)
Human neural stem cells (NSCs) are particularly valuable for the study of neurogenesis process and have a therapeutic potential in treating neurodegenerative disorders. However, current progress in the use of human NSCs is limited due to the available NSC sources
Giuseppe Pettinato et al.
PloS one, 9(11), e100742-e100742 (2014-11-05)
We report a technology to form human embryoid bodies (hEBs) from singularized human embryonic stem cells (hESCs) without the use of the p160 rho-associated coiled-coil kinase inhibitor (ROCKi) or centrifugation (spin). hEB formation was tested under four conditions: +ROCKi/+spin, +ROCKi/-spin
Etti Ben-Shushan et al.
Stem cells (Dayton, Ohio), 33(2), 403-415 (2014-10-23)
In the pMN domain of the spinal cord, Notch signaling regulates the balance between motor neuron differentiation and maintenance of the progenitor state for later oligodendrocyte differentiation. Here, we sought to study the role of Notch signaling in regulation of
Xueyan Shao et al.
Drug metabolism and pharmacokinetics, 30(1), 97-104 (2015-03-12)
Dehydroepiandrosterone sulfotransferase (SULT2A1) plays an important role in the detoxification of hydroxyl-containing xenobitotics and in the regulation of the biological activities of hydroxysteroids. Although dopamine (DA) is a vital neurotransmitter, DA also has some special functions in outer peripheral system
Luiz F Ferrari et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 6107-6116 (2015-04-17)
Hyperalgesic priming, a form of neuroplasticity in nociceptors, is a model of the transition from acute to chronic pain in the rat, which involves signaling from the site of an acute tissue insult in the vicinity of the peripheral terminal
A Gupta et al.
British journal of pharmacology, 172(2), 704-719 (2014-07-06)
Opioid receptor function is modulated by post-activation events such as receptor endocytosis, recycling and/or degradation. While it is generally understood that the peptide ligand gets co-endocytosed with the receptor, relatively few studies have investigated the role of the endocytosed peptide
Satomi Oyama et al.
Archives of biochemistry and biophysics, 541, 21-29 (2013-11-19)
Indoles are composed of a common core structure, the indole ring, and are widely used as pharmaceuticals and their precursors. In this study, a newly composed relatively small indole compound, AWT-489 was examined to find a novel specific antagonist for
Ketty Bacallao et al.
PloS one, 10(2), e0116948-e0116948 (2015-02-24)
Isolated Schwann cells (SCs) respond to cAMP elevation by adopting a differentiated post-mitotic state that exhibits high levels of Krox-20, a transcriptional enhancer of myelination, and mature SC markers such as the myelin lipid galactocerebroside (O1). To address how cAMP
Junko Nio-Kobayashi et al.
Molecular human reproduction, 21(8), 645-654 (2015-05-25)
Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and
Debolina Ray et al.
The American journal of pathology, 185(4), 1061-1072 (2015-03-22)
During cholestatic liver disease, there is dysregulation in the balance between biliary growth and loss in bile duct-ligated (BDL) rats modulated by neuroendocrine peptides via autocrine/paracrine pathways. Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and
Nicole M Warrington et al.
Cancer research, 75(1), 16-21 (2014-11-09)
Identifying modifiers of glioma risk in patients with type I neurofibromatosis (NF1) could help support personalized tumor surveillance, advance understanding of gliomagenesis, and potentially identify novel therapeutic targets. Here, we report genetic polymorphisms in the human adenylate cyclase gene adenylate
Floriana Volpicelli et al.
PloS one, 9(10), e109671-e109671 (2014-10-29)
Estrogens promote a plethora of effects in the CNS that profoundly affect both its development and mature functions and are able to influence proliferation, differentiation, survival and neurotransmission. The biological effects of estrogens are cell-context specific and also depend on
Terry E Machen
American journal of physiology. Cell physiology, 291(2), C218-C230 (2006-07-11)
The lack of functional cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in the apical membranes of CF airway epithelial cells abolishes cAMP-stimulated anion transport, and bacteria, eventually including Pseudomonas aeruginosa, bind to and accumulate in the mucus. Flagellin released from
Entsar Saheb et al.
Iranian journal of parasitology, 10(2), 213-229 (2015-08-08)
Acanthamoeba castellanii forms a resistant cyst that protects the parasite against the host's immune response. Acanthamoeba Type-I metacaspase (Acmcp) is a caspase-like protein that has been found to be expressed during the encystations. Dictyostelium discoideum is an organism closely related
M Kyle Cromer et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4062-4067 (2015-03-20)
Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin
Yoshio Tanaka et al.
Clinical and experimental pharmacology & physiology, 32(7), 503-514 (2005-07-20)
1. The beta-adrenoceptor is currently classified into beta(1), beta(2) and beta(3) subtypes and all three subtypes are expressed in smooth muscle. Each beta-adrenoceptor subtype exhibits tissue-specific distribution patterns, which may be a determinant controlling the mechanical functions of corresponding smooth
Seong-Hoon Kim et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 175-184 (2014-11-06)
To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, these drugs produce undesirable side effects. An alternative strategy is needed, and
Guanliang Chen et al.
Reproductive toxicology (Elmsford, N.Y.), 57, 100-110 (2015-06-07)
Effects of triphenyl phosphate (TPP) and tris-(2-chloroethyl) phosphate (TCEP) exposure on induction of oxidative stress and endocrine disruption were investigated in TM3 cells. After 24h exposure, cell growth declined and morphology changed in TPP and TCEP treated groups with high
Wenru Su et al.
Journal of immunology (Baltimore, Md. : 1950), 203(6), 1436-1446 (2019-08-20)
Therapeutic manipulation of regulatory T cells (Tregs) has been regarded as a promising approach for the treatment of immune disorders. However, a better understanding of the immunomodulatory mechanisms of Tregs and new safe and effective methods to improve the therapeutic
Yves P Auberson et al.
ChemMedChem, 10(2), 266-275 (2014-11-14)
Ergolines were recently identified as a novel class of H3 receptor (H3R) inverse agonists. Although their optimization led to drug candidates with encouraging properties for the treatment of narcolepsy, brain penetration remained low. To overcome this issue, ergoline 1 ((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)-carboxamide))
A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.
Cong Xu et al.
Cell, 155(4), 909-921 (2013-11-12)
Ex vivo expansion of satellite cells and directed differentiation of pluripotent cells to mature skeletal muscle have proved difficult challenges for regenerative biology. Using a zebrafish embryo culture system with reporters of early and late skeletal muscle differentiation, we examined
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