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关键词:'AB1783'
显示 1-30 共 122 条结果 关于 "AB1783" 范围 论文
Susana I Ramos et al.
Developmental cell, 52(4), 477-491 (2020-02-26)
Most adult neurons and glia originate from radial glial progenitors (RGs), a type of stem cell typically extending from the apical to the basal side of the developing cortex. Precise regulation of the choice between RG self-renewal and differentiation is
Sarah Jolly et al.
Glia, 66(1), 47-61 (2017-08-11)
We show that the G protein-coupled receptor GPR37-like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes. Comparison of wild type and
Robyn A Umans et al.
Frontiers in cell and developmental biology, 9, 654338-654338 (2021-07-17)
An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are best studied in vivo and great
Veronika Brezovakova et al.
Cells, 11(9) (2022-05-15)
Astrocytes regulate important functions in the brain, and their dysregulation has been linked to the etiology of neurodegenerative diseases, such as Alzheimer's disease (AD). The role of astroglia in human AD remains enigmatic, owing to the limitations of animal models
Anna P Miller et al.
PloS one, 12(3), e0173167-e0173167 (2017-03-07)
Blast traumatic brain injury (bTBI) affects civilians, soldiers, and veterans worldwide and presents significant health concerns. The mechanisms of neurodegeneration following bTBI remain elusive and current therapies are largely ineffective. It is important to better characterize blast-evoked cellular changes and
Alexandra E Schreiner et al.
The Journal of comparative neurology, 522(1), 204-224 (2013-08-14)
Astrocytes express two sodium-coupled transporters, glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1), which are essential for the maintenance of low extracellular glutamate levels. We performed a comparative analysis of the laminar and subcellular expression profile of GLAST and GLT-1 in
Anna C Pfalzer et al.
Metallomics : integrated biometal science, 12(7), 1118-1130 (2020-05-19)
Manganese (Mn) is an essential micronutrient required for the proper function of several enzymes. Accumulating evidence demonstrates a selective decrease of bioavailable Mn in vulnerable cell types of Huntington's Disease (HD), an inherited progressive neurodegenerative disorder with no cure. Amelioration
Rujin Tian et al.
Journal of neuropathology and experimental neurology, 69(4), 335-345 (2010-05-08)
Alexander disease (AxD) is a leukodystrophy caused by heterozygous mutations in the gene for glial fibrillary acidic protein, an intermediate filament protein expressed by astrocytes. The mutation causes prominent protein aggregates inside astrocytes; there is also loss of myelin and
Benjamin P Heithoff et al.
Glia, 69(2), 436-472 (2020-09-22)
In the adult brain, multiple cell types are known to produce factors that regulate blood-brain barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for mature astrocytes at the BBB. To determine if astrocytes contribute a nonredundant
Hilmarie Muniz-Talavera et al.
PloS one, 12(12), e0184957-e0184957 (2017-12-07)
During the first postnatal week of mouse development, radial glial cells lining the ventricles of the brain differentiate into ependymal cells, undergoing a morphological change from pseudostratified cuboidal cells to a flattened monolayer. Concomitant with this change, multiple motile cilia
Yedy Israel et al.
Addiction biology, 26(1), e12853-e12853 (2019-11-17)
Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued relapse. Studies show that brain oxidative stress is consistently associated with alcohol-induced neuroinflammation, and literature implies that oxidative stress and
Silvana Valtcheva et al.
Nature communications, 7, 13845-13845 (2016-12-21)
Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set the strength and timing of synaptic inputs. The conditions required for the emergence of Hebbian plasticity from distributed neural activity remain elusive.
Ricardo L Azevedo-Pereira et al.
Cell reports, 42(4), 112353-112353 (2023-04-13)
Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we
Magdalena Renner et al.
The EMBO journal, 36(10), 1316-1329 (2017-03-12)
Cerebral organoids recapitulate human brain development at a considerable level of detail, even in the absence of externally added signaling factors. The patterning events driving this self-organization are currently unknown. Here, we examine the developmental and differentiative capacity of cerebral
Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia.
Krock, BL; Bilotta, J; Perkins, BD
Proceedings of the National Academy of Sciences of the USA null
R C Roberts et al.
Neuroscience, 277, 522-540 (2014-07-30)
The process of glutamate release, activity, and reuptake involves the astrocyte, the presynaptic and postsynaptic neurons. Glutamate is released into the synapse and may occupy and activate receptors on both neurons and astrocytes. Glutamate is rapidly removed from the synapse
Kati L Healey et al.
Addiction neuroscience, 4 (2023-01-17)
Alcohol consumption in adolescence causes multiple acute negative changes in neural and behavioral function that persist well into adulthood and possibly throughout life. The medial prefrontal cortex (mPFC) and dorsal hippocampus are critical for executive function and memory and are
Sharmely Sharon Ballon Romero et al.
Frontiers in immunology, 14, 1213710-1213710 (2023-11-13)
Pain within the trigeminal system, particularly dental pain, is poorly understood. This study aimed to determine whether single or multiple dental pulp injuries induce persistent pain, its association with trigeminal central nociceptive pathways and whether electroacupuncture (EA) provides prolonged analgesic
Mykhailo Y Batiuk et al.
The Journal of biological chemistry, 292(21), 8874-8891 (2017-04-05)
Astrocytes are a major cell type in the mammalian CNS. Astrocytes are now known to play a number of essential roles in processes including synapse formation and function, as well as blood-brain barrier formation and control of cerebral blood flow.
Lauren Taylor Rosenblum et al.
Experimental neurology, 292, 145-153 (2017-03-28)
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at
Yohan van de Looij et al.
Frontiers in endocrinology, 10, 46-46 (2019-02-26)
Introduction: Intrauterine Growth Restriction (IUGR) refers to an impaired development of the fetus and hence results in adverse neurodevelopmental and psychiatric consequences later in life. Lactoferrin (Lf) is a glycoprotein present in milk that has already shown neuroprotective effects through
Borislav Dejanovic et al.
Nature aging, 2(9), 837-850 (2023-04-29)
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent manner. In addition to microglia, we
Giovanni Cirillo et al.
PloS one, 11(3), e0152750-e0152750 (2016-03-31)
Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could represent a valid therapeutic strategy to prevent maladaptive synaptic plasticity in central nervous system (CNS). Inhibition of matrix metalloproteinases (MMPs) and maintaining a neurotrophic support could represent two
Alaa M Hammad et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 55(3), 254-263 (2020-02-27)
Glutamate has been considered as neurotransmitter that is critical in triggering relapse to drugs of abuse, including ethanol and cocaine. Extracellular glutamate concentrations are tightly regulated by several mechanisms, including reuptake through glutamate transporters. Glutamate transporter type 1 (GLT-1) is
Shelley L Forrest et al.
Neurochemical research (2022-08-06)
Astrocytes are a major class of glial cell in the central nervous system that have a diverse range of types and functions thought to be based on their anatomical location, morphology and cellular properties. Recent studies highlight that astrocyte dysfunction
Paula Garcia-Esparcia et al.
Frontiers in aging neuroscience, 10, 122-122 (2018-05-15)
Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of
Juan M Angueyra et al.
Frontiers in cell and developmental biology, 6, 110-110 (2018-10-05)
Retinal degenerations are a heterogeneous group of diseases characterized by death of photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of blindness in developed countries (Bourne et al., 2017; De Bode, 2017) and currently have no
Danielle M Giangrasso et al.
Frontiers in molecular neuroscience, 16, 1160157-1160157 (2023-05-30)
The shift from drug abuse to addiction is considered to arise from the transition between goal-directed and habitual control over drug behavior. Habitual responding for appetitive and skill-based behaviors is mediated by potentiated glutamate signaling in the dorsolateral striatum (DLS)
Stephanie Dooves et al.
The Journal of clinical investigation, 126(4), 1512-1524 (2016-03-15)
Vanishing white matter (VWM) is a fatal leukodystrophy that is caused by mutations in genes encoding subunits of eukaryotic translation initiation factor 2B (eIF2B). Disease onset and severity are codetermined by genotype. White matter astrocytes and oligodendrocytes are almost exclusively
Paulina Cieślik et al.
International journal of molecular sciences, 22(22) (2021-11-28)
MK-801, an NMDA receptor antagonist, and scopolamine, a cholinergic receptor blocker, are widely used as tool compounds to induce learning and memory deficits in animal models to study schizophrenia or Alzheimer-type dementia (AD), respectively. Memory impairments are observed after either
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