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Veronica Fuentes-Santamaría et al.
Frontiers in cellular neuroscience, 13, 67-67 (2019-03-19)
Insulin-like growth factor 1 (IGF-1) is a powerful regulator of synaptic activity and a deficit in this protein has a profound impact on neurotransmission, mostly on excitatory synapses in both the developing and mature auditory system. Adult Igf1-/- mice are
The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.
Bellesi, M; Conti, F
Neuropsychopharmacology null
Kanako Takahashi et al.
International journal of molecular sciences, 24(16) (2023-08-26)
Human induced pluripotent stem cell (hiPSC)-derived neural cells have started to be used in safety/toxicity tests at the preclinical stage of drug development. As previously reported, hiPSC-derived neurons exhibit greater tolerance to excitotoxicity than those of primary cultures of rodent
Emily L Munger et al.
The Journal of comparative neurology, 530(18), 3106-3125 (2022-07-22)
Astrocytes are the main homeostatic cell of the brain involved in many processes related to cognition, immune response, and energy expenditure. It has been suggested that the distribution of astrocytes is associated with brain size, and that they are specialized
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Charron, G; Doudnikoff, E; Canron, MH; Li, Q; Vega, C; Marais, S; Baufreton, J; Vital et al.
Frontiers in Aging Neuroscience null
Robyn A Umans et al.
Frontiers in cell and developmental biology, 9, 654338-654338 (2021-07-17)
An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are best studied in vivo and great
Veronika Brezovakova et al.
Cells, 11(9) (2022-05-15)
Astrocytes regulate important functions in the brain, and their dysregulation has been linked to the etiology of neurodegenerative diseases, such as Alzheimer's disease (AD). The role of astroglia in human AD remains enigmatic, owing to the limitations of animal models
Susana I Ramos et al.
Developmental cell, 52(4), 477-491 (2020-02-26)
Most adult neurons and glia originate from radial glial progenitors (RGs), a type of stem cell typically extending from the apical to the basal side of the developing cortex. Precise regulation of the choice between RG self-renewal and differentiation is
J M Wilcox et al.
Neurobiology of disease, 158, 105486-105486 (2021-08-28)
Non-convulsive epileptiform activity is a common and under-studied comorbidity of Alzheimer's disease that may significantly contribute to onset of clinical symptoms independently of other neuropathological features such as β-amyloid deposition. We used repeated treatment with low dose kainic acid (KA)
Tara M DeSilva et al.
The Journal of comparative neurology, 520(17), 3912-3932 (2012-04-24)
The major regulators of synaptic glutamate in the cerebral cortex are the excitatory amino acid transporters 1-3 (EAAT1-3). In this study, we determined the cellular and temporal expression of EAAT1-3 in the developing human cerebral cortex. We applied single- and
Alexandra E Schreiner et al.
The Journal of comparative neurology, 522(1), 204-224 (2013-08-14)
Astrocytes express two sodium-coupled transporters, glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1), which are essential for the maintenance of low extracellular glutamate levels. We performed a comparative analysis of the laminar and subcellular expression profile of GLAST and GLT-1 in
Sarah Jolly et al.
Glia, 66(1), 47-61 (2017-08-11)
We show that the G protein-coupled receptor GPR37-like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes. Comparison of wild type and
Anna P Miller et al.
PloS one, 12(3), e0173167-e0173167 (2017-03-07)
Blast traumatic brain injury (bTBI) affects civilians, soldiers, and veterans worldwide and presents significant health concerns. The mechanisms of neurodegeneration following bTBI remain elusive and current therapies are largely ineffective. It is important to better characterize blast-evoked cellular changes and
Magdalena Renner et al.
The EMBO journal, 36(10), 1316-1329 (2017-03-12)
Cerebral organoids recapitulate human brain development at a considerable level of detail, even in the absence of externally added signaling factors. The patterning events driving this self-organization are currently unknown. Here, we examine the developmental and differentiative capacity of cerebral
R C Roberts et al.
Neuroscience, 277, 522-540 (2014-07-30)
The process of glutamate release, activity, and reuptake involves the astrocyte, the presynaptic and postsynaptic neurons. Glutamate is released into the synapse and may occupy and activate receptors on both neurons and astrocytes. Glutamate is rapidly removed from the synapse
Mykhailo Y Batiuk et al.
The Journal of biological chemistry, 292(21), 8874-8891 (2017-04-05)
Astrocytes are a major cell type in the mammalian CNS. Astrocytes are now known to play a number of essential roles in processes including synapse formation and function, as well as blood-brain barrier formation and control of cerebral blood flow.
Li Li et al.
Cell death discovery, 10(1), 64-64 (2024-02-07)
Amyloid beta (Abeta) synergistically enhances excitotoxicity of glutamate load by impairing glutamate transporter 1 (GLT1) expression and function, which exacerbates the development of Alzheimer's disease (AD). Our previous studies suggested that sulbactam can upregulate the expression levels and capacity of
Anna C Pfalzer et al.
Metallomics : integrated biometal science, 12(7), 1118-1130 (2020-05-19)
Manganese (Mn) is an essential micronutrient required for the proper function of several enzymes. Accumulating evidence demonstrates a selective decrease of bioavailable Mn in vulnerable cell types of Huntington's Disease (HD), an inherited progressive neurodegenerative disorder with no cure. Amelioration
Rujin Tian et al.
Journal of neuropathology and experimental neurology, 69(4), 335-345 (2010-05-08)
Alexander disease (AxD) is a leukodystrophy caused by heterozygous mutations in the gene for glial fibrillary acidic protein, an intermediate filament protein expressed by astrocytes. The mutation causes prominent protein aggregates inside astrocytes; there is also loss of myelin and
Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia.
Krock, BL; Bilotta, J; Perkins, BD
Proceedings of the National Academy of Sciences of the USA null
Yedy Israel et al.
Addiction biology, 26(1), e12853-e12853 (2019-11-17)
Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued relapse. Studies show that brain oxidative stress is consistently associated with alcohol-induced neuroinflammation, and literature implies that oxidative stress and
Giovanni Cirillo et al.
PloS one, 11(3), e0152750-e0152750 (2016-03-31)
Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could represent a valid therapeutic strategy to prevent maladaptive synaptic plasticity in central nervous system (CNS). Inhibition of matrix metalloproteinases (MMPs) and maintaining a neurotrophic support could represent two
Lauren Taylor Rosenblum et al.
Experimental neurology, 292, 145-153 (2017-03-28)
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at
Victor Bodart-Santos et al.
Stem cell research & therapy, 10(1), 332-332 (2019-11-22)
Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety of biomolecules, including mRNAs, miRNAs, and proteins. We hypothesized that EVs derived from
Benjamin P Heithoff et al.
Glia, 69(2), 436-472 (2020-09-22)
In the adult brain, multiple cell types are known to produce factors that regulate blood-brain barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for mature astrocytes at the BBB. To determine if astrocytes contribute a nonredundant
Ricardo L Azevedo-Pereira et al.
Cell reports, 42(4), 112353-112353 (2023-04-13)
Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we
Hilmarie Muniz-Talavera et al.
PloS one, 12(12), e0184957-e0184957 (2017-12-07)
During the first postnatal week of mouse development, radial glial cells lining the ventricles of the brain differentiate into ependymal cells, undergoing a morphological change from pseudostratified cuboidal cells to a flattened monolayer. Concomitant with this change, multiple motile cilia
Sharmely Sharon Ballon Romero et al.
Frontiers in immunology, 14, 1213710-1213710 (2023-11-13)
Pain within the trigeminal system, particularly dental pain, is poorly understood. This study aimed to determine whether single or multiple dental pulp injuries induce persistent pain, its association with trigeminal central nociceptive pathways and whether electroacupuncture (EA) provides prolonged analgesic
Silvana Valtcheva et al.
Nature communications, 7, 13845-13845 (2016-12-21)
Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set the strength and timing of synaptic inputs. The conditions required for the emergence of Hebbian plasticity from distributed neural activity remain elusive.
Kati L Healey et al.
Addiction neuroscience, 4 (2023-01-17)
Alcohol consumption in adolescence causes multiple acute negative changes in neural and behavioral function that persist well into adulthood and possibly throughout life. The medial prefrontal cortex (mPFC) and dorsal hippocampus are critical for executive function and memory and are
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