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显示 1-30 共 273 条结果 关于 "b2629" 范围 论文
Arpita Roychoudhury et al.
Biological chemistry, 394(11), 1465-1474 (2013-09-12)
Compatible solutes are small, uncharged, zwitter ionic, osmotically active molecules produced and accumulated by microorganisms inside their cell to counteract different kinds of environmental stress. They enhance protein stability without interfering with the metabolic pathways even at molar concentrations. In
Z L Hegedus et al.
Archives internationales de physiologie et de biochimie, 96(5), 211-221 (1988-12-01)
The fluorescence excitation and emission spectra observed in plasma from patients with chronic renal failure were reproduced by the generation of soluble lipofuscins in normal plasma samples by incubation with mixtures of L-dopa, dopamine, L-norepinephrine, L-epinephrine, 3-hydroxy-DL-kynurenine and 3-hydroxy-anthranilic acid
Caroline Koshy et al.
The EMBO journal, 32(23), 3096-3105 (2013-10-22)
Bilayer lipids contribute to the stability of membrane transporters and are crucially involved in their proper functioning. However, the molecular knowledge of how surrounding lipids affect membrane transport is surprisingly limited and despite its general importance is rarely considered in
Simon Kluters et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 37-46 (2015-11-02)
Cation exchange chromatography (CEX) is an integral part of many downstream processes for monoclonal antibodies (mAbs). However, in some cases CEX methods with standard mobile phase conditions do not lead to a sufficient removal of soluble antibody aggregates. The addition
Kenneth Day et al.
PloS one, 9(10), e111756-e111756 (2014-10-31)
Current target enrichment systems for large-scale next-generation sequencing typically require synthetic oligonucleotides used as capture reagents to isolate sequences of interest. The majority of target enrichment reagents are focused on gene coding regions or promoters en masse. Here we introduce
Lila Ghamsari et al.
BMC genomics, 12 Suppl 1, S4-S4 (2011-08-10)
Recent advances in the field of metabolic engineering have been expedited by the availability of genome sequences and metabolic modelling approaches. The complete sequencing of the C. reinhardtii genome has made this unicellular alga a good candidate for metabolic engineering
Dafna A Windhorst et al.
Developmental psychobiology, 57(1), 35-49 (2014-09-25)
This study is the first to investigate the longitudinal effects of gene-environment interplay between DRD4 genotype and maternal sensitivity on child externalizing behavior. Multiple measures of maternal sensitivity (14, 36, and 48 months) and externalizing behavior (18 months, 36 months
Roger C Diehl et al.
Biochemistry, 52(35), 5997-6010 (2013-08-06)
To quantify interactions of the osmolyte l-proline with protein functional groups and predict their effects on protein processes, we use vapor pressure osmometry to determine chemical potential derivatives dμ2/dm3 = μ23, quantifying the preferential interactions of proline (component 3) with
Kuan-Hui Hsu et al.
Current eye research, 40(3), 267-273 (2014-05-17)
To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness. Profiles of the release of osmoprotectant betaine and moisturizing agent dexpanthenol from senofilcon
Hussain Mohamad Awwad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 41-45 (2014-03-29)
We aimed at developing a method for the measurement of choline and its metabolites in whole blood (WB). After an extraction step, quantification of choline, betaine, and dimethylglycine (DMG) was performed using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
Steven H Zeisel
Nutrition reviews, 64(2 Pt 1), 77-79 (2006-03-16)
Betaine supplementation in humans has been shown to lower plasma homocysteine concentrations in modestly hyperhomocysteinemic patients. Betaine treatment is associated with increased plasma low-density-lipoprotein (LDL) cholesterol, suggesting that although betaine supplementation lowers homocysteine, a risk factor for cardiovascular disease, changes
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.
Ramsey I Zeitoun et al.
Nature biotechnology, 33(6), 631-637 (2015-03-24)
Multiplexed genome engineering approaches can be used to generate targeted genetic diversity in cell populations on laboratory timescales, but methods to track mutations and link them to phenotypes have been lacking. We present an approach for tracking combinatorial engineered libraries
Ruzhi Deng et al.
Molecular vision, 20, 1243-1252 (2014-10-30)
Hyperosmolarity has been recognized as a proinflammatory stress in the pathogenesis of dry eye disease. This study investigated the suppressive effect of osmoprotectants (L-carnitine, erythritol, and betaine) on the production and activity of matrix metalloproteinases (MMPs) in primary human corneal
L Garcia-Gonzalez et al.
International journal of food microbiology, 129(3), 253-263 (2009-01-23)
High pressure carbon dioxide (HPCD) treatment is currently considered as an attractive non-thermal process for preserving food. Industrial application of this technique requires, among others, systematic (quantitative) data on the inactivation of food relevant pathogenic and spoilage microorganisms, and in-depth
Shailendra P Singh et al.
Biochemical and biophysical research communications, 433(1), 84-89 (2013-03-05)
Fremyella diplosiphon is a freshwater cyanobacterium that exhibits complementary chromatic adaptation (CCA), which allows the organism to alter its pigmentation and cellular morphology to maximally harvest available green light (GL) and red light (RL) at different depth levels in its
Liang Wu et al.
GigaScience, 4, 51-51 (2015-11-10)
Viral infection causes multiple forms of human cancer, and HPV infection is the primary factor in cervical carcinomas. Recent single-cell RNA-seq studies highlight the tumor heterogeneity present in most cancers, but virally induced tumors have not been studied. HeLa is
Paula Dominguez-Salas et al.
The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)
Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were
Mahmoud S Khaniani et al.
Molecular cytogenetics, 1, 5-5 (2008-05-13)
Fragile X syndrome (OMIM #300624) is the most common, recognised, heritable cause of mental retardation. Widespread testing is warranted by the relatively high frequency of the disorder, the benefits of early detection and the identification of related carriers whose offspring
Z Wang et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(11), O825-O830 (2014-05-13)
Resistance of Bordetella pertussis, the causative agent of pertussis, to erythromycin is rare. Recently, several Chinese isolates were found to be erythromycin resistant. This study aimed to investigate the occurrence of pertussis in children suffering persistent cough and the prevalence
Yan-Jie Tian et al.
The British journal of nutrition, 111(9), 1594-1601 (2014-02-11)
Recent evidence shows that excess nicotinamide can cause epigenetic changes in developing rats. The aim of the present study was to investigate the effects of maternal nicotinamide supplementation on the fetus. Female rats were randomised into four groups fed a
Kristina M Cammen et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 150-158 (2014-12-03)
In coastal marine ecosystems, neurotoxins produced by harmful algal blooms (HABs) often result in large-scale mortality events of many marine species. Historical and frequent exposure to HABs therefore may provide a strong selective pressure for adaptations that result in toxin
Dong Hwan Kim et al.
International journal of oncology, 45(3), 1250-1256 (2014-06-28)
Betaine is an important human nutrient obtained from various foods and studies in animals and humans have provided results suggesting their pathogenesis of various chronic diseases and points to a role in risk assessment and disease prevention. However, the molecular
Andrew J Ocque et al.
Journal of pharmaceutical and biomedical analysis, 109, 128-135 (2015-03-15)
A simple, sensitive, and precise ultra-high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of trimethylamine N-oxide, choline, and betaine in human plasma and urine. Sample preparation involved protein precipitation with methanol containing internal
Xiude Hua et al.
Analytical chemistry, 86(16), 8441-8447 (2014-08-20)
Two immuno-loop-mediated isothermal amplification assays (iLAMP) were developed by using a phage-borne peptide that was isolated from a cyclic eight-peptide phage library. One assay was used to screen eight organophosphorus (OP) pesticides with limits of detection (LOD) between 2 and
Paul G Thomes et al.
Biochemical pharmacology, 96(1), 30-38 (2015-05-02)
Alcoholic liver disease (ALD) is a major healthcare challenge worldwide. Emerging evidence reveals that ethanol administration disrupts the intestinal epithelial tight junction (TJ) complex; this defect allows for the paracellular translocation of gut-derived pathogenic molecules to reach the liver to
Lance R Parsons et al.
mBio, 6(2) (2015-04-02)
Herpes simplex virus (HSV) is a widespread pathogen that causes epithelial lesions with recurrent disease that manifests over a lifetime. The lifelong aspect of infection results from latent viral infection of neurons, a reservoir from which the virus reactivates periodically.
Tom Vander Hoogerstraete et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(33), 11757-11766 (2015-07-17)
In a conventional solvent extraction system, metal ions are distributed between two immiscible phases, typically an aqueous and an organic phase. In this paper, the proof-of-principle is given for the distribution of metal ions between three immiscible phases, two ionic
Serge Y Ongagna-Yhombi et al.
Applied and environmental microbiology, 81(1), 351-363 (2014-10-26)
Vibrio parahaemolyticus is a halophile that is the predominant cause of bacterial seafood-related gastroenteritis worldwide. To survive in the marine environment, V. parahaemolyticus must have adaptive strategies to cope with salinity changes. Six putative compatible solute (CS) transport systems were
A mysterious case of dysphagia demystified by medication reconciliation.
Karthik Ragunathan et al.
The American journal of medicine, 126(6), e1-e1 (2013-05-21)
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