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显示 1-30 #N/A 461 条结果 关于 "B4126" 范围 论文
Brian I Carr et al.
Seminars in oncology, 41(2), 252-258 (2014-05-03)
Cirrhosis-related abnormal liver function is associated with predisposition to hepatocellular carcinoma (HCC). It features in several HCC classification systems and is an HCC prognostic factor. The aim of the present study was to examine the phenotypic tumor differences in HCC
Ni Lin et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(4), 815-832 (2015-02-12)
Sinoporphyrin sodium (DVDMS) is a novel hematoporphyrin-like photosensitizer developed for photodynamic therapy (PDT), an effective therapeutic modality for tumor treatment; however, the safety of photosensitizer-based PDT is always of great concern. The purpose of the current study was to investigate
Eltrombopag and serum of a different hue.
David Cardamone et al.
Archives of pathology & laboratory medicine, 137(9), 1175-1175 (2013-09-03)
Ki-Chul Sung et al.
The American journal of cardiology, 112(12), 1873-1879 (2013-09-26)
Whether conjugated bilirubin concentration, resulting from hepatic UDP-glucuronosyltransferase 1 A1 activity, is associated with cardiovascular disease is unknown. Our aim was to investigate the relation between serum conjugated bilirubin concentrations and coronary artery calcium score (CACS) as a measure of
Xiaoyan Chu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 851-863 (2015-03-31)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for
Eun-Sook Jeong et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 10-18 (2014-07-19)
1. Fimasartan is an angiotensin receptor II antagonist used to treat patients with hypertension. This drug is mainly excreted into bile as either the parent compound or a glucuronide conjugate. In this study, we examined the glucuronidation of fimasartan and
Stacy Kern et al.
South Dakota medicine : the journal of the South Dakota State Medical Association, 68(1), 23-27 (2015-02-03)
Most newborn infants develop hyperbilirubinemia in the neonatal period. Excessive levels of hyperbilirubinemia places the infant at risk for bilirubin encephalopathy. We discuss the metabolism of bilirubin and the most likely etiologies for elevated bilirubin levels in the newborn. We
A Yeşilkaya et al.
International journal of clinical & laboratory research, 28(4), 230-234 (1999-01-08)
Recently, it has been suggested that bilirubin may act as a potent biological chain-breaking antioxidant. To observe the effects of free bilirubin on antioxidant reactions in cumene hydroperoxide-treated erythrocytes (15 g hemoglobin/dl), we added bilirubin at four different concentrations (0.5
Rowan A Stringer et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1117-1124 (2014-04-15)
The simultaneous effects of the cytochrome P450 inhibitor 1-aminobenzotriazole (ABT) on inhibition of in vivo metabolism and gastric emptying were evaluated with the test compound 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole(NVS-CRF38), a novel corticotropin releasing factor receptor 1 (CRF1) antagonist with low water solubility, and
Akiko Kumagai et al.
Cell, 153(7), 1602-1611 (2013-06-19)
The fluorescent protein toolbox has revolutionized experimental biology. Despite this advance, no fluorescent proteins have been identified from vertebrates, nor has chromogenic ligand-inducible activation or clinical utility been demonstrated. Here, we report the cloning and characterization of UnaG, a fluorescent
Çağıl Gökdoğan et al.
Brazilian journal of otorhinolaryngology, 82(2), 144-150 (2016-01-05)
Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss
Azza A G Tantawy et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(4), 419-425 (2015-02-24)
Endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide, is a major determinant of endothelial function. Several eNOS gene polymorphisms have been reported as 'susceptibility genes' in various human diseases states, including cardiovascular, pulmonary and renal diseases. We
G C Oniscu et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2846-2854 (2014-10-07)
Organs recovered from donors after circulatory death (DCD) suffer warm ischemia before cold storage which may prejudice graft survival and result in a greater risk of complications after transplant. A period of normothermic regional perfusion (NRP) in the donor may
Sara Heebøll et al.
Pharmacological research, 95-96, 34-41 (2015-03-31)
Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are increasing clinical problems for which effective treatments are required. The polyphenol resveratrol prevents the development of fatty liver disease in a number of experimental studies. We hypothesized that it could revert
Robert D Christensen et al.
Transfusion, 54(12), 3068-3074 (2014-06-05)
It is not clear whether red blood cell (RBC) transfusions typically increase a neonate's total serum bilirubin (TSB) level or if so by how much. In this retrospective analysis, from 2009 through 2012, we collected TSB measurements before and after
Muammer Kara et al.
European journal of gastroenterology & hepatology, 27(10), 1144-1148 (2015-06-11)
It has been reported that the neutrophil-to-lymphocyte ratio (NLR) can be measured relatively easily and can serve as a valuable index for much clinical pathology. The aim of this study was to investigate the association between NLR and hepatic histological
José Altamirano et al.
Gastroenterology, 146(5), 1231-1239 (2014-01-21)
There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality. We analyzed data from 121 patients
Changes in the auditory brainstem response associated with intravenous infusion of unconjugated bilirubin into infant rhesus monkeys
Ahlfors C E, et al.
Pediatric Research, 20(6), 511-511 (1986)
Juan-Ni Gong et al.
Chinese medical journal, 128(23), 3125-3131 (2015-11-28)
Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our
S Nadalin et al.
Pediatric transplantation, 19(4), 358-365 (2015-04-17)
Biliary complications remain a major challenge for long-term success after LT, as it is, as a rule, the most common technical - early and late - complication that occurs, and because these complications contribute to a significant number of late
Monica Lapa et al.
Lung, 192(6), 981-986 (2014-09-15)
The aim of this study was to evaluate the expression profiles of the relevant selectins and PDGF in schistosomiasis-associated pulmonary hypertension. Patients with three distinct clinical profiles were enrolled in the study: IPAH(n = 11), schistosomiasis-associated PH (Sch-PH))(n = 13)
Diana J Leeming et al.
Scandinavian journal of gastroenterology, 50(5), 584-592 (2015-02-03)
The hepatic venous pressure gradient (HVPG) is an important but invasive diagnostic and prognostic marker in cirrhotic patients. The aim of the study was to evaluate a novel biochemical plasma marker of true type V collagen formation (Pro-C5) for describing
Lu Song et al.
Archives of pathology & laboratory medicine, 138(7), 950-954 (2014-07-01)
Monoclonal proteins can interfere with the conjugated bilirubin assay on the Beckman Coulter AU5400 and AU2700 instruments and produce spurious results. Protein depletion eliminates the interference, suggesting that monoclonal proteins cause the problem. To determine the interference rate with the
Zhong-Hua Lu et al.
World journal of gastroenterology, 20(48), 18354-18359 (2015-01-07)
To investigate T helper 17/regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids. The study included 20 patients in the early stage of severe hepatitis B (SHB) and 11 healthy controls. All patients had elevated
Leonardo Lorente et al.
PloS one, 10(3), e0121739-e0121739 (2015-03-31)
There have been found apoptotic changes in brain tissue samples from animals and humans after a traumatic brain injury (TBI). The protein cytokeratin 18 (CK-18), present in epithelial cells, is cleaved by the action of caspases during apoptosis, and the
Kohsuke Tsuchiya et al.
European journal of immunology, 44(12), 3696-3707 (2014-09-25)
Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In
Sanjiv B Amin et al.
Seminars in perinatology, 35(3), 134-140 (2011-06-07)
Neonatal jaundice (hyperbilirubinemia), which is extremely common in neonates, can be associated with neurotoxicity. A safe level of bilirubin has not been defined in either premature or term infants. Emerging evidence suggest that the level of unbound (or "free") bilirubin
Kinga A Szucs et al.
Pediatrics, 131(6), e1982-e1985 (2013-05-15)
Jaundice develops in most newborn infants and is one of the most common reasons infants are rehospitalized after birth. American Academy of Pediatrics clinical practice guidelines strongly support the recommendation that clinicians promote and support breastfeeding. Recognizing that the disruptions
Gail J Pyne-Geithman et al.
Acta neurochirurgica. Supplement, 115, 267-273 (2012-08-15)
Despite intensive research efforts, by our own team and many others, the molecules responsible for acute neurological damage following subarachnoid hemorrhage (SAH) and contributing to delayed ischemic neurological deficit (DIND) have not yet been elucidated. While there are a number
Evaluating elevated bilirubin levels in asymptomatic adults.
Lisa B VanWagner et al.
JAMA, 313(5), 516-517 (2015-02-04)
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