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显示 1-30 共 442 条结果 关于 "D5025" 范围 论文
Olga A Boubriak et al.
Journal of anatomy, 222(3), 341-348 (2013-01-15)
The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the disc-vertebral body interface. Loss of this nutrient supply is thought to lead to disc degeneration, but
António Galvão et al.
Endocrinology, 157(2), 858-871 (2015-12-15)
In the present work, we investigated the role of Nodal, an embryonic morphogen from the TGFβ superfamily in corpus luteum (CL) secretory activity using cells isolated from equine CL as a model. Expression pattern of Nodal and its receptors activin
Jing Wang et al.
Journal of hazardous materials, 373, 504-518 (2019-04-05)
Previous studies have demonstrated that toxins produced by toxic cyanobacterial blooms are hazardous materials. Although microcystin-LR (MC-LR) has been revealed to inflict damage to the brain, the mechanisms underlying its neurotoxicity as a result of chronic exposure to MC-LR are
Victoria Male et al.
Methods in molecular biology (Clifton, N.J.), 612, 447-463 (2009-12-25)
Natural killer (NK) cells account for 70% of the leukocytes in the mucosal lining of the uterus (the decidua) in the first trimester of pregnancy. They are CD56(superbright) granulated cells expressing a repertoire of Killer-cell Immunoglobulin-like Receptors (KIR) skewed towards
Heterologous expression of receptors and signaling proteins in adult mammalian sympathetic neurons by microinjection.
S R Ikeda
Methods in molecular biology (Clifton, N.J.), 83, 191-202 (1997-01-01)
Myles Robert Minter et al.
Journal of neuroinflammation, 12, 71-71 (2015-04-17)
Neuro-inflammation has long been implicated as a contributor to the progression of Alzheimer's disease in both humans and animal models. Type-1 interferons (IFNs) are pleiotropic cytokines critical in mediating the innate immune pro-inflammatory response. The production of type-1 IFNs following
Weilin Liu et al.
Molecular therapy oncolytics, 17, 350-360 (2020-05-15)
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious regimens of in situ vaccination. Intratumoral
Aline V Probst et al.
Developmental cell, 19(4), 625-638 (2010-10-19)
At the time of fertilization, the paternal genome lacks the typical configuration and marks characteristic of pericentric heterochromatin. It is thus essential to understand the dynamics of this region during early development, its importance during that time period and how
Shan Li et al.
The Journal of pathology, 252(2), 165-177 (2020-07-21)
Infiltration of activated T cells into renal tissue plays an essential role in inflammatory nephropathy. However, the mechanism enabling the renal recruitment and activation of T cells remains elusive. Here we report that inflammatory cytokine-promoted antigen presentation by podocytes is
Xiaofei Tian et al.
Frontiers in psychiatry, 11, 815-815 (2020-09-10)
Delayed neurologic sequelae (DNS) are recurrent-transient neuropsychiatric consequences of carbon monoxide (CO) intoxication. Pathologically DNS features damages to the brain white matter. Here we test a hypothesis that direct cytotoxicity of CO to oligodendrocytes plays a role in the development
Teresia N Macharia et al.
Microorganisms, 8(9) (2020-09-25)
Root-knot nematode (RKN) Meloidogyne javanica presents a great challenge to Solanaceae crops, including potato. In this study, we investigated transcriptional responses of potato roots during a compatible interaction with M. javanica. In this respect, differential gene expression of Solanum tuberosum
Xue Dong et al.
Frontiers in immunology, 13, 896472-896472 (2022-06-21)
Thymic epithelial cells (TECs) critically participate in T cell maturation and selection for the establishment of immunity to foreign antigens and immune tolerance to self-antigens of T cells. It is well known that many intracellular and extracellular molecules elegantly have
Nir Bujanover et al.
Stem cell reports, 16(8), 1884-1893 (2021-07-24)
Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows various viral or bacterial stimuli
Naveen Sharma et al.
The Journal of experimental medicine, 218(7) (2021-05-12)
Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy. In this study, we found inhibitory receptor LILRB4 on a variety of intratumoral immune cell types in murine tumor models and human cancers, most prominently on TAMs. LILRB4, known
Yan-Yan Wu et al.
Journal of economic entomology, 108(4), 1486-1494 (2015-10-16)
Honey bees are at an unavoidable risk of exposure to neonicotinoid pesticides, which are used worldwide. Compared with the well-studied roles of these pesticides in nontarget site (including midgut, ovary, or salivary glands), little has been reported in the target
Nadine Lehmann et al.
Frontiers in immunology, 11, 1819-1819 (2020-09-26)
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer. Tumor cells can be recognized and killed by conventional and
Ela Elyada et al.
Cancer discovery, 9(8), 1102-1123 (2019-06-15)
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefined. Here we
Hanshen Yang et al.
Cell death and differentiation, 30(2), 560-575 (2022-12-21)
Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modification of PD-L1 has potential value in immunosuppression. Here, we identified that ubiquitin-specific protease
Carlos O Oueslati Morales et al.
Traffic (Copenhagen, Denmark), 22(12), 454-470 (2021-09-27)
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the brain. The continuous trafficking of AMPARs into and out of synapses is a core feature of synaptic plasticity, which is considered as the cellular
Yuqiu Lu et al.
Methods in molecular biology (Clifton, N.J.), 2377, 333-343 (2021-10-29)
Identification of genes essential for structure, function, and survival of a cell type is critical for understanding of the underlying mechanisms. Unfortunately, there is no efficient way to identify such genes. Studies by single-cell RNA sequencing have shown that gene
Fei Teng et al.
Cell reports, 37(8), 110051-110051 (2021-11-25)
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role in the airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched in the lung-draining lymph nodes of healthy mice
Jing Zhou et al.
Translational oncology, 15(1), 101262-101262 (2021-11-13)
Pancreatic cancer (PaC) is resistant to immune checkpoint therapy, but the underlying mechanisms are largely unknown. In this study, we have established four orthotopic PaC murine models with different PaC cell lines by intra-pancreatic inoculation. Therapeutic examinations demonstrate that only
Xue Dong et al.
European journal of immunology, 52(11), 1789-1804 (2022-08-01)
Thymic epithelial cells (TECs) are important for T cell development and immune tolerance establishment. Although comprehensive molecular regulation of TEC development has been studied, the role of transport protein particle complexes (Trappcs) in TECs is not clear. Using TEC-specific homozygous
Joel R Wilmore et al.
Cell host & microbe, 23(3), 302-311 (2018-02-27)
Serum immunoglobulin A (IgA) antibodies are readily detected in mice and people, but the mechanisms underlying the induction of serum IgA and its role in host protection remain uncertain. We report that select commensal bacteria induce several facets of systemic
Martin Grimm et al.
BMC cancer, 13, 569-569 (2013-12-07)
Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonuclease DNaseX (DNaseI-like 1) has been used to identify the Apo10 protein epitope
Alessandro Roncador et al.
Biophysical chemistry, 229, 115-122 (2017-05-10)
We report a comprehensive study of the biocompatibility and neurocompatibility of titanium dioxide films (TiO
Julien Gros et al.
The EMBO journal, 33(6), 621-636 (2014-02-26)
The separation of DNA replication origin licensing and activation in the cell cycle is essential for genome stability across generations in eukaryotic cells. Pre-replicative complexes (pre-RCs) license origins by loading Mcm2-7 complexes in inactive form around DNA. During origin firing
David Bauché et al.
Immunity, 49(2), 342-352 (2018-08-12)
Interleukin-22 (IL-22)-producing group 3 innate lymphoid cells (ILC3) maintains gut homeostasis but can also promote inflammatory bowel disease (IBD). The regulation of ILC3-dependent colitis remains to be elucidated. Here we show that Foxp3+ regulatory T cells (Treg cells) prevented ILC3-mediated colitis in
Zhen Wang et al.
Frontiers in oncology, 10, 540484-540484 (2020-11-13)
Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast cancer metastasis
Snehal Sonawane et al.
Investigative ophthalmology & visual science, 53(13), 8253-8263 (2012-11-22)
We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil extracellular trap (NET) accumulation in the precorneal tear film, thus causing ocular surface inflammation. Exfoliated
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