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John T Benjamin et al.
The Journal of clinical investigation, 131(1) (2020-10-28)
Emerging evidence indicates that early life events can increase the risk for developing chronic obstructive pulmonary disease (COPD). Using an inducible transgenic mouse model for NF-κB activation in the airway epithelium, we found that a brief period of inflammation during
SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
Pilat, et al.
The Journal of Clinical Investigation, 133 (2023)
Esmé T I van der Gracht et al.
iScience, 24(1), 101954-101954 (2021-01-19)
Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell heterogeneity is however required to enhance vaccination and immunotherapy approaches. Here we examined the impact of pathogen- and
Baris Alten et al.
Neuron, 109(1), 59-72 (2020-11-05)
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex, composed of synaptobrevin, syntaxin, and SNAP25, forms the essential fusion machinery for neurotransmitter release. Recent studies have reported several mutations in the gene encoding SNAP25 as a causative factor for developmental
Caroline Perner et al.
Immunity, 53(5), 1063-1077 (2020-10-26)
Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens encountered in vivo, but not in vitro. This suggests that another cell in the dermis
Femke Stephan et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(3), 686-693 (2014-02-28)
Removal of dead cells is essential in the maintenance of tissue homeostasis, and efficient removal prevents exposure of intracellular content to the immune system, which could lead to autoimmunity. The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from
Yoshiaki Nakamura et al.
Cell stem cell, 28(8), 1443-1456 (2021-04-14)
A remarkable feature of tissue stem cells is their ability to regenerate the structure and function of host tissue following transplantation. However, the dynamics of donor stem cells during regeneration remains largely unknown. Here we conducted quantitative clonal fate studies
Liling Wang et al.
Theranostics, 12(17), 7216-7236 (2022-11-29)
Rationale: Recurrent pregnancy loss (RPL) is a distressing disorder that seriously affects the physical and psychological health of women. RPL is also a sentinel risk marker for future obstetric complications and warrants in-depth investigation. Abnormal polarization and functions of decidual
Nikolaj Riis Christensen et al.
iScience, 25(2), 103808-103808 (2022-02-25)
The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein-protein interactions (PPIs) which constitute a functional postsynapse. The PSD protein 95 (PSD-95) interacts with a manifold of proteins, including the C-terminal of transmembrane
Christine Steinhäuser et al.
Current protocols in immunology, 105, 14-14 (2014-04-05)
Macrophages and polymorphonuclear neutrophils are professional phagocytes essential in the initial host response against intracellular pathogens such as Mycobacterium tuberculosis. Phagocytosis is the first step in phagocyte-pathogen interaction, where the pathogen is engulfed into a membrane-enclosed compartment termed a phagosome.
Marina Li et al.
Cancers, 12(11) (2020-11-22)
Formation of neutrophil extracellular traps (NETs) has been associated with multiple pathologies including cancer. While the visualization of NETs by microscopy is a routine technique, their quantification presents a number of challenges. Commonly, as citrullination of histone H3 is required
Sambrook, J., and Russell, D.W.
Molecular Cloning: A Laboratory Manual, 2(2), 5-5 (2001)
Elise Kaspi et al.
PloS one, 12(8), e0183136-e0183136 (2017-08-15)
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2. The alternative splicing of LMNA
Chuntao Wu et al.
iScience, 26(1), 105723-105723 (2023-01-03)
Lipid metabolism is extensively reprogrammed in pancreatic ductal adenocarcinoma (PDAC). Stearoyl-coenzyme A desaturase (SCD) is a critical lipid regulator that was unexplored in PDAC. Here, we characterized the existence of cancer-associated fibroblasts (CAFs) with high SCD expression, and revealed them
Szu-Ting Chen et al.
Nature communications, 8(1), 299-299 (2017-08-22)
The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular
Jianhuang Lin et al.
Nature communications, 12(1), 5321-5321 (2021-09-09)
CARM1 is often overexpressed in human cancers including in ovarian cancer. However, therapeutic approaches based on CARM1 expression remain to be an unmet need. Cancer cells exploit adaptive responses such as the endoplasmic reticulum (ER) stress response for their survival
Isoelectric focusing of multiple forms of DNase in thin layers of polyacrylamide gel and detection of enzymatic activity with a zymogram method following separation.
H S Kim et al.
Analytical biochemistry, 119(1), 96-101 (1982-01-01)
Zhu Tao et al.
Cells, 11(22) (2022-11-27)
Immune checkpoint blockade therapy (ICB) is ineffective against cold tumors and, although it is effective against some hot tumors, drug resistance can occur. We have developed a Plasmodium immunotherapy (PI) that can overcome these shortcomings. However, the specific killing effect
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
Mingyu Liu et al.
The Journal of experimental medicine, 219(4) (2022-03-11)
The spleen is an important site of hematopoietic stem/progenitor cell (HSPC) preconditioning and tumor-promoting myeloid cell generation in cancer, but the regulatory mechanism remains unclear. Here, we found that PKR-like endoplasmic reticulum kinase (PERK) mediated HSPC reprogramming into committed MDSC
Ofer Elhanani et al.
Cell reports, 31(5), 107591-107591 (2020-05-07)
The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a limited understanding of the underlying mechanisms. Using an in vitro
Allan Lazarovici et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6376-6381 (2013-04-12)
DNA binding proteins find their cognate sequences within genomic DNA through recognition of specific chemical and structural features. Here we demonstrate that high-resolution DNase I cleavage profiles can provide detailed information about the shape and chemical modification status of genomic
Junko Nishimura
Methods in molecular biology (Clifton, N.J.), 1887, 85-94 (2018-12-07)
Polysaccharides produced by lactic acid bacteria are divided into two classes based on their biosynthesis and structure. Nevertheless, the procedures for isolation, purification, and chemical analysis of these polymers are very similar. This chapter introduces the techniques that are used
Luca Peruzzotti-Jametti et al.
PLoS biology, 19(4), e3001166-e3001166 (2021-04-08)
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it is now clear that transplanted
Manoj Chelvanambi et al.
Journal for immunotherapy of cancer, 9(2) (2021-02-03)
The degree of immune infiltration in tumors, especially CD8+ T cells, greatly impacts patient disease course and response to interventional immunotherapy. Enhancement of tumor infiltrating lymphocyte (TIL) is a critical element of efficacious therapy and one that may be achieved
Mengwen Hu et al.
Nature communications, 13(1), 4510-4510 (2022-08-11)
The ovarian reserve defines the female reproductive lifespan, which in humans spans decades due to robust maintenance of meiotic arrest in oocytes residing in primordial follicles. Epigenetic reprogramming, including DNA demethylation, accompanies meiotic entry, but the chromatin changes that underpin
Masahiro Uehara et al.
Scientific reports, 10(1), 4441-4441 (2020-03-12)
The DNA damage response after kidney injury induces cell cycle arrest in renal tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting interstitial fibrosis in a paracrine manner. Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step
E Tuite et al.
European journal of biochemistry, 243(1-2), 482-492 (1997-01-15)
Linear and circular dichroic spectroscopies have been employed to investigate the effects of small DNA ligands on the interactions of two proteins which bind to the minor groove of DNA, viz. RecA protein from Escherichia coli and deoxyribonuclease I (bovine
Noboru J Sakabe et al.
Science advances, 6(49) (2020-12-04)
While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in
Gaetana Restivo et al.
Communications biology, 5(1), 1144-1144 (2022-10-29)
Biobanking of surplus human healthy and disease-derived tissues is essential for diagnostics and translational research. An enormous amount of formalin-fixed and paraffin-embedded (FFPE), Tissue-Tek OCT embedded or snap-frozen tissues are preserved in many biobanks worldwide and have been the basis
Hemant B Badgandi et al.
The Journal of cell biology, 216(3), 743-760 (2017-02-06)
The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understood. In this study, we determine that the tubby family protein TULP3 functions as a
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