跳转至内容
Merck
CN
搜索范围

D5025

应用筛选条件
关键词:'D5025'
显示 1-30 #N/A 442 条结果 关于 "D5025" 范围 论文
Aline V Probst et al.
Developmental cell, 19(4), 625-638 (2010-10-19)
At the time of fertilization, the paternal genome lacks the typical configuration and marks characteristic of pericentric heterochromatin. It is thus essential to understand the dynamics of this region during early development, its importance during that time period and how
Olga A Boubriak et al.
Journal of anatomy, 222(3), 341-348 (2013-01-15)
The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the disc-vertebral body interface. Loss of this nutrient supply is thought to lead to disc degeneration, but
Fei Teng et al.
Cell reports, 37(8), 110051-110051 (2021-11-25)
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role in the airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched in the lung-draining lymph nodes of healthy mice
Xue Dong et al.
European journal of immunology, 52(11), 1789-1804 (2022-08-01)
Thymic epithelial cells (TECs) are important for T cell development and immune tolerance establishment. Although comprehensive molecular regulation of TEC development has been studied, the role of transport protein particle complexes (Trappcs) in TECs is not clear. Using TEC-specific homozygous
Jing Zhou et al.
Translational oncology, 15(1), 101262-101262 (2021-11-13)
Pancreatic cancer (PaC) is resistant to immune checkpoint therapy, but the underlying mechanisms are largely unknown. In this study, we have established four orthotopic PaC murine models with different PaC cell lines by intra-pancreatic inoculation. Therapeutic examinations demonstrate that only
Xue Dong et al.
Frontiers in immunology, 13, 896472-896472 (2022-06-21)
Thymic epithelial cells (TECs) critically participate in T cell maturation and selection for the establishment of immunity to foreign antigens and immune tolerance to self-antigens of T cells. It is well known that many intracellular and extracellular molecules elegantly have
Martin Grimm et al.
BMC cancer, 13, 569-569 (2013-12-07)
Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonuclease DNaseX (DNaseI-like 1) has been used to identify the Apo10 protein epitope
Carlos O Oueslati Morales et al.
Traffic (Copenhagen, Denmark), 22(12), 454-470 (2021-09-27)
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the brain. The continuous trafficking of AMPARs into and out of synapses is a core feature of synaptic plasticity, which is considered as the cellular
Ela Elyada et al.
Cancer discovery, 9(8), 1102-1123 (2019-06-15)
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefined. Here we
Hanshen Yang et al.
Cell death and differentiation, 30(2), 560-575 (2022-12-21)
Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modification of PD-L1 has potential value in immunosuppression. Here, we identified that ubiquitin-specific protease
Heterologous expression of receptors and signaling proteins in adult mammalian sympathetic neurons by microinjection.
S R Ikeda
Methods in molecular biology (Clifton, N.J.), 83, 191-202 (1997-01-01)
Shan Li et al.
The Journal of pathology, 252(2), 165-177 (2020-07-21)
Infiltration of activated T cells into renal tissue plays an essential role in inflammatory nephropathy. However, the mechanism enabling the renal recruitment and activation of T cells remains elusive. Here we report that inflammatory cytokine-promoted antigen presentation by podocytes is
Teresia N Macharia et al.
Microorganisms, 8(9) (2020-09-25)
Root-knot nematode (RKN) Meloidogyne javanica presents a great challenge to Solanaceae crops, including potato. In this study, we investigated transcriptional responses of potato roots during a compatible interaction with M. javanica. In this respect, differential gene expression of Solanum tuberosum
Joel R Wilmore et al.
Cell host & microbe, 23(3), 302-311 (2018-02-27)
Serum immunoglobulin A (IgA) antibodies are readily detected in mice and people, but the mechanisms underlying the induction of serum IgA and its role in host protection remain uncertain. We report that select commensal bacteria induce several facets of systemic
Myles Robert Minter et al.
Journal of neuroinflammation, 12, 71-71 (2015-04-17)
Neuro-inflammation has long been implicated as a contributor to the progression of Alzheimer's disease in both humans and animal models. Type-1 interferons (IFNs) are pleiotropic cytokines critical in mediating the innate immune pro-inflammatory response. The production of type-1 IFNs following
Weilin Liu et al.
Molecular therapy oncolytics, 17, 350-360 (2020-05-15)
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious regimens of in situ vaccination. Intratumoral
Xiaofei Tian et al.
Frontiers in psychiatry, 11, 815-815 (2020-09-10)
Delayed neurologic sequelae (DNS) are recurrent-transient neuropsychiatric consequences of carbon monoxide (CO) intoxication. Pathologically DNS features damages to the brain white matter. Here we test a hypothesis that direct cytotoxicity of CO to oligodendrocytes plays a role in the development
Naveen Sharma et al.
The Journal of experimental medicine, 218(7) (2021-05-12)
Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy. In this study, we found inhibitory receptor LILRB4 on a variety of intratumoral immune cell types in murine tumor models and human cancers, most prominently on TAMs. LILRB4, known
Alessandro Roncador et al.
Biophysical chemistry, 229, 115-122 (2017-05-10)
We report a comprehensive study of the biocompatibility and neurocompatibility of titanium dioxide films (TiO
Yuqiu Lu et al.
Methods in molecular biology (Clifton, N.J.), 2377, 333-343 (2021-10-29)
Identification of genes essential for structure, function, and survival of a cell type is critical for understanding of the underlying mechanisms. Unfortunately, there is no efficient way to identify such genes. Studies by single-cell RNA sequencing have shown that gene
Yan-Yan Wu et al.
Journal of economic entomology, 108(4), 1486-1494 (2015-10-16)
Honey bees are at an unavoidable risk of exposure to neonicotinoid pesticides, which are used worldwide. Compared with the well-studied roles of these pesticides in nontarget site (including midgut, ovary, or salivary glands), little has been reported in the target
Snehal Sonawane et al.
Investigative ophthalmology & visual science, 53(13), 8253-8263 (2012-11-22)
We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil extracellular trap (NET) accumulation in the precorneal tear film, thus causing ocular surface inflammation. Exfoliated
Victoria Male et al.
Methods in molecular biology (Clifton, N.J.), 612, 447-463 (2009-12-25)
Natural killer (NK) cells account for 70% of the leukocytes in the mucosal lining of the uterus (the decidua) in the first trimester of pregnancy. They are CD56(superbright) granulated cells expressing a repertoire of Killer-cell Immunoglobulin-like Receptors (KIR) skewed towards
Pablo Nicolás De Francesco et al.
Cell and tissue research, 369(2), 369-380 (2017-04-18)
Hypothalamic tanycytes are specialized bipolar ependymal cells that line the floor of the third ventricle. Given their strategic location, tanycytes are believed to play several key functions including being a selective barrier and controlling the amount of hypothalamic-derived factors reaching
Luana Naia et al.
Bio-protocol, 8(8), e2823-e2823 (2018-04-20)
Primary cultures of murine striatal neurons are widely used to explore cellular mechanisms in neurobiology, including brain diseases. Here we describe a detailed and standardized protocol to dissect and culture embryonic murine striatal neurons GABA-positive/DARPP-32-positive for 12 days in vitro
A Iu Konev et al.
Tsitologiia, 55(3), 198-203 (2013-06-26)
This article presents an analysis of the causes of chromatin decompaction of interbands in Drosophila polytene chromosomes. On the example of interband 3C6/C7 of X chromosome, we investigate the ability of different DNA segments from the region to form an
V S Chouhan et al.
Theriogenology, 84(7), 1185-1196 (2015-08-06)
The purpose of this study was to evaluate the temporal (24, 48, and 72 hours) and dose-dependent (0, 5, 10, and 100 ng/mL of LH, insulin-like growth factor 1 [IGF-1], and EGF) in vitro expression and secretion patterns of vascular
Adam N R Cartwright et al.
Cancer immunology research, 9(4), 470-485 (2021-01-31)
Tumor-infiltrating myeloid-derived suppressor cells (MDSC) are associated with poor survival outcomes in many human cancers. MDSCs inhibit T cell-mediated tumor immunity in part because they strongly inhibit T-cell function. However, whether MDSCs inhibit early or later steps of T-cell activation
Marta Trüb et al.
Journal for immunotherapy of cancer, 8(2) (2020-07-04)
The costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as target for cancer therapy. Systemic 4-1BB directed therapies elicit toxicity or low efficacy, which significantly hampered advancement of 4-1BB-based
Anton Maximov et al.
Journal of neuroscience methods, 161(1), 75-87 (2006-11-23)
Various techniques have been applied for the functional analysis of synaptic transmission in cultured neurons. Here, we describe a method of studying synaptic transmission in neurons cultured at high-density from different brain regions such as the cortex, striatum and spinal
1/15