搜索范围
D8418
应用筛选条件
关键词:'D8418'
显示 1-30 #N/A 7931 条结果 关于 "D8418" 范围 论文
Hongwei Peng et al.
Molecular medicine reports, 11(2), 881-886 (2014-10-30)
Neuroblastoma is a common solid malignant tumor of the sympathetic nervous system, which contributes to 15% of cancer‑related mortality in children. The differentiation status of neuroblastoma is correlated with clinical outcome, and the induction of differentiation thus constitutes a therapeutic
Tünde Fekete et al.
Journal of leukocyte biology, 96(4), 579-589 (2014-07-09)
Type I and III IFNs are crucial, soluble components of potent antiviral responses. It has been explored recently that mTOR is involved in the regulation of IFN-α/β production by pDCs, albeit its role in the induction of IFN responses in
Ling Yu et al.
Biochimica et biophysica acta, 1848(11 Pt A), 2859-2867 (2015-08-19)
This investigation was conducted to study the relationship between intracellular Ca(2+) and activation of large conductance Ca(2+)-activated K(+) (BK) currents by unoprostone, the first synthetic docosanoid. We used HEK293 cells stably transfected with two BK channel splice variants, one sensitive
Sarah M McLeod et al.
Journal of bacteriology, 197(6), 1075-1082 (2015-01-15)
In Gram-negative bacteria, lipoproteins are transported to the outer membrane by the Lol system. In this process, lipoproteins are released from the inner membrane by the ABC transporter LolCDE and passed to LolA, a diffusible periplasmic molecular chaperone. Lipoproteins are
Florian Sevelda et al.
Journal of experimental & clinical cancer research : CR, 34, 134-134 (2015-11-04)
Enhanced signalling via the epidermal growth factor receptor (EGFR) is a hallmark of multiple human carcinomas. However, in recent years data have accumulated that EGFR might also be hyperactivated in human sarcomas. Aim of this study was to investigate the
David M Foureau et al.
Cancer immunology, immunotherapy : CII, 63(12), 1329-1340 (2014-09-11)
Interleukin-2 (IL-2) therapy leads to clinically relevant responses in 10-16 % of patients with metastatic melanoma (MMEL) or 10-30 % of patients with metastatic renal cell carcinoma (MRCC). To date, no biomarkers have been validated to identify patients who are likely to
Yu-Shu Huang et al.
Food chemistry, 174, 571-576 (2014-12-23)
Curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. Curcumin is a potent substance with several functions, including antioxidant, antitumor, anti-inflammatory, antimicrobial, antiparasitic, antimutagenic, chemopreventive and chemotherapeutic activities. Matrix-assisted laser
Mitochondrial membrane potential profile and its correlation with increasing sperm motility.
Paoli D et al
Fertility and Sterility, 95(7), 2315-2319 (2011)
Kazuki N Sugahara et al.
Molecular cancer therapeutics, 14(1), 120-128 (2014-11-14)
Tumor-specific tissue-penetrating peptides deliver drugs into extravascular tumor tissue by increasing tumor vascular permeability through interaction with neuropilin (NRP). Here, we report that a prototypic tumor-penetrating peptide iRGD (amino acid sequence: CRGDKGPDC) potently inhibits spontaneous metastasis in mice. The antimetastatic
Dawei Zhang et al.
Materials science & engineering. C, Materials for biological applications, 42, 70-77 (2014-07-27)
Gold nanoparticles (AuNPs) have shown great promise for a variety of applications, including chemistry, biology, and medicine. Recently, AuNPs have found promising applications in cartilage and bone repair. However, to realize the above promised applications, more work needs to be
Joanna Boros-Majewska et al.
Medical microbiology and immunology, 203(5), 341-355 (2014-06-14)
Opportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these
Maik Dahlhoff et al.
FEBS letters, 589(12), 1376-1382 (2015-04-19)
The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile
Hanru Wang et al.
Cancer biology & therapy, 15(5), 560-569 (2014-02-22)
We evaluated the capacity for supernatants (SNs) derived from Escherichia coli Nissle 1917 (EcN), cultured under different growth conditions, to prevent 5-fluorouracil (5-FU)-induced intestinal epithelial cell damage. EcN was cultured in: Luria Bertani (LB) broth, tryptone soya broth (TSB), de
Osama A Alsaied et al.
Surgery, 156(2), 270-279 (2014-06-24)
Sorafenib is the only drug approved by the Food and Drug Administration for metastatic hepatocellular carcinoma (HCC). Triptolide, a diterpene triepoxide, exhibits antineoplastic properties in multiple tumor cell types. In this study, we examined the effects of these agents and
Silvana Pasetto et al.
PloS one, 9(12), e115323-e115323 (2014-12-30)
HIV infection by sexual transmission remains an enormous global health concern. More than 1 million new infections among women occur annually. Microbicides represent a promising prevention strategy that women can easily control. Among emerging therapies, natural small molecules such as
Y Chen et al.
Transplantation proceedings, 46(5), 1649-1657 (2014-06-18)
The efficacy of any bioartificial liver device requires both rapid production and proper bioactivity of the cells for the bioreactor. The goal of this study was to observe the effect of spinner speed and cell density on the proliferation of
Xingqiang Lai et al.
Lasers in medical science, 30(7), 1941-1948 (2015-07-27)
Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). This study aimed to investigate the efficacy and potential mechanism of HMME-PDT under irradiation of green light-emitting diode (LED) with wavelength of 530 ± 20 nm in treating
Baihe Chen et al.
British journal of pharmacology, 171(15), 3741-3753 (2014-04-23)
Cardiac rupture is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. Here we investigated the effect of the angiotensin II receptor blocker olmesartan (Olm) on
Suhashini S Dhumale et al.
IUBMB life, 67(5), 361-373 (2015-05-20)
The receptor for advanced glycation end-products (RAGE) is a multiligand member of the immunoglobulin superfamily, which plays an important role in maintaining cellular homeostasis. It is normally expressed on immune cells, including macrophages, monocytes, dendritic cells and T cells to
Shinsuke Hashida et al.
Oncology reports, 33(3), 1499-1504 (2015-01-22)
Acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is a critical issue that needs to be overcome in the treatment of patients with non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. EGFR and AKT are client
Marie-Eve Charbonneau et al.
PloS one, 9(8), e104096-e104096 (2014-08-06)
The global spread of anti-microbial resistance requires urgent attention, and diverse alternative strategies have been suggested to address this public health concern. Host-directed immunomodulatory therapies represent one approach that could reduce selection for resistant bacterial strains. Recently, the small molecule
Alessandra Berto et al.
Food & function, 6(9), 3081-3090 (2015-07-28)
Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For
Erik Niemelä et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 11-21 (2015-07-18)
Cancerous cells have a rapid metabolism by which they take up sugars, such as glucose, at significantly higher rates than normal cells. Celastrol is a traditional herbal medicine known for its anti-inflammatory and anti-cancer activities. The poor aqueous solubility and
Laila Ziko et al.
BioMed research international, 2015, 430569-430569 (2015-02-17)
Cisplatin (CisPt) is a commonly used platinum-based chemotherapeutic agent. Its efficacy is limited due to drug resistance and multiple side effects, thereby warranting a new approach to improving the pharmacological effect of CisPt. A newly developed mathematical hypothesis suggested that
Hartmut Glaeser et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(9), 883-891 (2014-06-21)
Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known whether such transporters contribute to the cellular
Pragati P Nahar et al.
Journal of medicinal food, 18(7), 786-792 (2014-12-10)
Inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, Alzheimer's disease, and cancer. An overwhelming amount of data indicates that curcumin, a polyphenol obtained from the Indian spice turmeric
Liuwei Jiang et al.
Journal of chromatography. A, 1410, 200-209 (2015-08-09)
Native poly(ethylene terephthalate) (PET) capillary-channeled polymer (C-CP) fibers have been previously studied as stationary phases for reversed phase and affinity protein separations. In this study, surface modified PET C-CP fibers were evaluated for the anion exchange separation of proteins. The
Chie Amano et al.
PloS one, 10(9), e0137207-e0137207 (2015-09-12)
To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to prepare liposomal curcumin, and
Xiao-Li Bao et al.
Pharmaceutical biology, 53(1), 117-124 (2014-09-27)
Abstract Context: Most of the present studies on the antitumor efficiency of Cymbopogon citratus (DC.) Stapf (Gramineae) are limited to its low-mass compounds, and little information about the antitumor activity of polysaccharides from this plant is available. This study focused
Katja Storch et al.
Oncology reports, 33(4), 2009-2016 (2015-01-28)
Glioblastoma multiforme (GBM) is a highly aggressive and extremely lethal cancer and novel molecular therapies are required for optimized multimodal therapy regimes. While focal adhesion kinase (FAK) is regarded as a therapeutic target, its radiosensitizing potential remains to be elucidated in glioblastoma.
1/265